Clinical trials
Malignancy clinical trials
Below are recruiting malignancy clinical trials, each written for real people, not researchers. We’re tracking 1,583 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04997993RecruitingPhase 1
Leflunomide for PTEN-altered or HER2-negative metastatic cancers
This Phase 1 trial studies whether leflunomide can slow or control advanced (metastatic) cancers in people whose tumors have specific PTEN changes or who have HER2-negative breast cancer. It’s primarily a safety-and-dosing study, but it may offer benefit if your cancer matches the tumor marker requirements.
New York, New YorkAges 18 years+ - NCT05134142Recruiting
Quality of life after hemipelvectomy for pelvic tumors
This study looks at how people with pelvic tumors feel and function after a hemipelvectomy (surgery removing part of the hip/pelvis). It aims to better understand recovery and day-to-day quality of life after this operation.
Houston, TexasAges Any age - NCT04704648Recruiting
Surgery for a one-eye surface tumor in people with HIV
This study looks at whether removing a suspected pre-cancer/cancer growth on the surface of the eye can be done safely in people living with HIV. It is a feasibility (safety and practical) study, helping doctors refine the best surgical approach and follow-up.
KampalaAges 18 years+ - NCT04908709Recruiting
MRI-guided proton therapy for high-grade brain tumors in children
This study looks at how metabolism in a child’s brain tumor changes during proton therapy, using special MRI scans. It may help doctors better understand treatment response and tailor care for pediatric high-grade gliomas.
Atlanta, GeorgiaAges Up to 21 years - NCT04832698Recruiting
Survey of radiology residents after endovascular simulator training
This study is a survey that asks current interventional and diagnostic radiology residents about their experience after training with an endovascular simulator. Your answers may help improve the simulator training program for future residents.
Houston, TexasAges 18 years+ - NCT04742881Recruiting
Laparoscopic colon surgery comparison for bowel tumors or disease
This trial studies a low-impact approach to colon or upper-rectum surgery using small cameras (laparoscopy) to see if it works well and is safe. You may be eligible if you are scheduled for a specific type of colon/rectal operation and can safely be monitored during the study.
BayonneAges 18 years+ - NCT05477849RecruitingPhase 1
Study drug for people with advanced solid tumors
This Phase 1 trial tests the safety and early effects of VG2025 in people with advanced solid cancers that have stopped responding to standard treatments. It’s mainly looking for side effects and how the body processes the drug, and it may offer a new option when other treatments haven’t worked.
Hangzhou, ZhejiangAges 18–75 - NCT03772561RecruitingPhase 1
Testing AZD5363, olaparib, and durvalumab for advanced solid cancers
This Phase 1 trial tests a combination of three medicines to shrink or control advanced solid tumors that are progressing or no standard options exist. It mainly focuses on safety and early signs of how well the treatment works.
Singapore, SingaporeAges 21–99 - NCT07101081Recruiting
HER2 in gynecologic cancers: a Brazilian study
This trial is looking at whether HER2, a protein linked to some cancers, is found in different gynecologic tumors. It tests stored tumor tissue from women in Brazil to learn more about this marker.
São PauloAges Any age - NCT04517656Recruiting
Testing blood markers after a bone marrow donor transplant
This trial checks how certain blood “biomarkers” change after you receive donor stem cells to rebuild your blood and immune system. The goal is to learn whether these markers can better predict your immune recovery after transplant.
Saint-EtienneAges 18 years+ - NCT02421380Recruiting
Tests how repeatable a special MRI scan is for tumors
This study checks whether a specialized MRI using injected “hyperpolarized pyruvate” gives consistent tumor images when repeated. It may help future patients by improving how reliably this scan can measure tumors.
Montvale, New JerseyAges 21–90 - NCT05354570RecruitingPhase 2
Radiation for thymic cancer that has spread to lung lining
This Phase 2 study tests a precise type of chest radiation that targets cancer in the lung lining (pleura) while trying to protect healthy lungs and organs. It may help people with thymic cancer that has spread to the pleura, including cases that return after prior treatment.
Basking Ridge, New JerseyAges 18–79 - NCT05053113Recruiting
Text-and-Fitbit support for less-active women to move more
This trial studies a peer-based (partner) approach using text messages and a Fitbit app to help inactive women increase their physical activity. It may help you find easier, ongoing motivation and support to reach recommended activity levels.
Houston, TexasAges 18–65 - NCT05620732Recruiting
CAR-T treatment for advanced stomach or pancreatic cancer
This trial tests a customized immune-cell treatment (CAR-T) for advanced stomach or pancreatic cancer that cannot be removed by surgery. It aims to use cells engineered to target a specific tumor marker to shrink cancer or slow its growth.
Shenzhen, GuangdongAges 18–75 - NCT04083183RecruitingPhase 1/Phase 2
Testing radiation plus antibody therapy for certain non-cancer diseases
This early-phase study tests a conditioning treatment using total-body irradiation and a radioactive antibody (called astatine-211) before a stem cell transplant for non-cancer conditions. The goal is to improve how well the donor cells take hold and are tolerated.
Seattle, WashingtonAges 18–49 - NCT03850418RecruitingPhase 2
Azacitidine for blood chimerism changes after transplant
This Phase 2 study tests whether azacitidine can improve outcomes when donor blood “chimerism” starts dropping after an allogeneic stem cell transplant. It’s for people with AML, MDS, MPN, or CMML who are experiencing early warning signs in their blood counts after transplant but without clear relapse in the bone marrow.
Detroit, MichiganAges 18–75 - NCT04237623RecruitingPhase 2
GM-CSF after transplant using a matched related donor
This Phase 2 study tests whether giving a medicine called GM-CSF after an allogeneic transplant (using a matched related donor) can improve outcomes. Participants must meet health and donor-matching requirements and be eligible to safely receive the treatment and consent to the study.
Atlanta, GeorgiaAges 18–78 - NCT04611087Recruiting
Weight-loss program participants: self-monitoring focus group
This trial is looking to learn from people who finished a specific weight-loss program recently and ask them to share their experiences. The goal is to improve how weight-loss support and tracking work for participants.
Houston, TexasAges Any age - NCT04007783Recruiting
Test of a new plan for jaw reconstruction and implants
This study checks whether the “O-bridge protocol” helps people who need jaw surgery—either for osteonecrosis of the jaw or for oral/jaw tumors—followed by dental implant placement to support fixed teeth (not removable dentures). The goal is to improve your ability to eat, speak, and get a stable tooth replacement plan after surgery.
AntwerpAges 18 years+ - NCT04118712Recruiting
Ovarian tissue banking for girls and teens having ovary surgery
This study collects small pieces of ovarian tissue during certain surgeries in girls and teens (before or after puberty). The goal is to bank the tissue for possible future fertility or medical research.
Chicago, IllinoisAges Up to 18 years - NCT03980769RecruitingPhase 2
Stem cell transplant trial for non-cancer blood disorders
This Phase 2 study tests a specific chemotherapy combination (treosulfan, fludarabine, and thiotepa) before an unrelated or matched donor stem cell transplant. It may help people with certain non-cancer blood and immune disorders by trying to reset the immune system using donor stem cells.
Seattle, WashingtonAges Up to 50 years - NCT05436561RecruitingPhase 2
Test a reduced transplant plan for older leukemia patients
This Phase 2 trial studies a “reduced-intensity” transplant plan for people age 55–65 who have certain blood cancers and a suitable donor. It may help older patients get the benefits of a transplant with less treatment burden, but it excludes people with serious organ problems or active infections.
Shanghai, Shanghai MunicipalityAges 55–65 - NCT03739827Recruiting
Study rare solid tumors and collect your health samples
This study follows people (and sometimes family members) connected to rare solid tumors and collects health information and samples (biospecimens). It helps researchers understand how these cancers develop and builds resources for future research, which may benefit you by contributing to better tailored care for rare cancers.
Bethesda, MarylandAges 4 weeks+ - NCT06160492RecruitingPhase 3
Testing a Glowing Dye to Improve Brain Tumor Removal
This trial compares two surgical techniques for removing malignant brain tumors: one using a special dye (5-ALA) that makes tumor cells glow under a blue light, versus the standard white light surgery. The goal is to see if the dye-guided approach helps surgeons remove more of the tumor safely.
Guangzhou, GuangdongAges 18–70
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Common questions
- Are there clinical trials for malignancy?
- Yes. Clin2 currently lists 1,583 recruiting malignancy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a malignancy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a malignancy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.