Clinical trials
Melanoma (Skin Cancer) clinical trials
Below are recruiting melanoma (skin cancer) clinical trials, each written for real people, not researchers. We’re tracking 153 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05389332Recruiting
Mobile WhatsApp program to help reduce skin cancer risk
This trial tests a mobile phone health program (using WhatsApp) to help Hispanic adults lower their risk of skin cancer. It focuses on encouraging better sun protection and checking your skin regularly.
New Brunswick, New JerseyAges 18–100 - NCT07287917RecruitingPhase 1/Phase 2
Testing a new drug combo for advanced breast cancer or melanoma
This trial tests a new combination of drugs (AMXT 1501, DFMO, and standard therapies) for people with advanced solid tumors, specifically breast cancer (ER+ HER2-) or melanoma that has progressed after other treatments. The goal is to see if this combination can help shrink tumors or slow their growth.
Tucson, ArizonaAges 18 years+ - NCT03906253Recruiting
Laser treatment to prevent skin growth in older adults
This trial tests whether a type of laser treatment can help protect older adults’ skin from turning actinic keratosis (a sun-related precancer) into more serious skin problems. It focuses on the forearms and may help reduce future skin damage while checking safety and comfort.
Dayton, OhioAges 60 years+ - NCT05794035Recruiting
Shorter radiation after skin cancer surgery for older adults
This study looks at whether giving a shorter course of radiation after surgery can help prevent skin cancer from coming back in people age 70 and older. It focuses on higher-risk skin cancers and checks how well the treatment works and what side effects occur.
CréteilAges 70 years+ - NCT07277920Recruiting
Skin lesion study using special microscope and genetics
This study looks at skin spots that might be unusual moles or early melanoma using a special microscope that sees deep into the skin. It aims to match these microscope images with genetic information to better understand these spots.
Modena, MoAges 18 years+ - NCT06899789Recruiting
Long-term follow-up of colitis from checkpoint inhibitors
This study follows people who developed colitis (inflammation in the colon) after receiving immune checkpoint inhibitors for cancer. Researchers want to learn about long-term effects and outcomes.
Pavia, PaviaAges 18 years+ - NCT06428721Recruiting
Can laser treatment prevent skin spots in older adults?
This study tests if a laser treatment on your forearms can prevent precancerous spots (actinic keratoses) from developing in older adults with fair skin. You would receive the laser on one arm and a sham treatment on the other, and your skin will be monitored.
Fairborn, OhioAges 60 years+ - NCT05955924RecruitingPhase 3
Nicotinamide to prevent skin cancer after organ transplant
This trial tests nicotinamide (a vitamin-like medicine) to help prevent new keratinocyte skin cancers in people who have had a kidney, liver, heart, or lung transplant. It may lower the chance of developing new skin tumors while you continue your usual transplant anti-rejection medicines.
Calgary, AlbertaAges 18 years+ - NCT06028724Recruiting
Looking for cancer mutations using a blood test
This study uses a blood test (liquid biopsy) to find genetic changes in advanced solid tumors. It may help doctors choose the right treatment and monitor how well it works over time.
Aviano, PordononeAges 18 years+ - NCT06627036RecruitingPhase 4
Dermoscopy vs standard marking for skin cancer removal
This trial compares two ways of marking skin before removing a non-melanoma skin cancer: using a special magnifying tool called a dermoscope versus the standard method. The goal is to see which method helps remove the cancer completely the first time.
HullAges 18 years+ - NCT07330323Recruiting
Custom skin cancer aftercare report study
This trial tests a personalized aftercare report for people with low-risk skin cancer. It aims to see if this report can improve follow-up care.
Leuven, Vlaams-BrabantAges 18–80 - NCT06163820RecruitingPhase 1/Phase 2
Bevacizumab and immunotherapy with radiation for melanoma brain metastases
This trial tests a combination of a drug that stops blood vessel growth (bevacizumab), immunotherapy, and focused radiation to treat melanoma that has spread to the brain and is causing symptoms. The goal is to see if this approach shrinks tumors and improves outcomes.
Melbourne, VictoriaAges 18 years+ - NCT05562791RecruitingPhase 1
Testing PSMA PET/CT scans for metastatic bladder or skin cancer
This Phase 1 study tests how well a PSMA PET/CT scan can find cancer spots in people with metastatic bladder cancer (urothelial cancer) or metastatic melanoma. It may help doctors better see where cancer is and guide next steps.
Basking Ridge, New JerseyAges 18 years+ - NCT03860883Recruiting
Comparing wider versus narrower surgery margins for stage II melanoma
This trial studies whether removing a slightly wider strip of skin around a melanoma improves outcomes compared with a narrower strip. It also uses a lymph node staging procedure to check spread and helps doctors fine-tune surgery for stage II melanoma.
Mobile, AlabamaAges 18 years+ - NCT05940311Recruiting
Blood test for melanoma with BRAF V600E mutation
This trial studies a very sensitive blood test to detect melanoma-related genetic changes in people with BRAF V600E. It may help track the disease more closely and guide care in advanced or high-risk situations.
RomeAges 18 years+ - NCT04038619RecruitingPhase 1
Fecal transplant for immune-therapy diarrhea or bowel inflammation
This early-phase study tests whether stool/fecal microbiota transplant (a fecal transplant) can help people who develop significant diarrhea or colitis after immune-checkpoint therapy. It aims to reduce bowel inflammation and improve symptoms, while carefully checking for infections.
Houston, TexasAges 18 years+ - NCT06630611RecruitingPhase 2
A new immune cell therapy for melanoma, lung, and cervical cancer
This trial tests a new way to boost your immune cells after they are collected from your tumor and grown in a lab. Instead of high-dose IL-2, you would get a modified version called ANV419, which may have fewer side effects.
BarcelonaAges 18 years+ - NCT06956690RecruitingPhase 1/Phase 2
Testing HMBD-501 for HER3-positive advanced solid tumors
This trial tests a new drug, HMBD-501, for people with advanced solid tumors that have a specific protein called HER3. The goal is to see if the drug is safe and if it can help shrink or control the cancer.
La Jolla, CaliforniaAges 18 years+ - NCT07681791Recruiting
Sun safety program for teens and parents
This trial tests a digital program to help teens and parents learn better sun safety habits together. It involves using Facebook daily to get tips and support, which may reduce skin cancer risk.
New Brunswick, New JerseyAges 13 years+ - NCT05746897RecruitingPhase 1
First-in-human test of an anti-PVRIG drug for advanced cancers
This early-phase study tests NM1F (an anti-PVRIG antibody) in people with advanced solid tumors to see if it’s safe and whether it may work. It also includes pembrolizumab (a PD-1 “checkpoint” medicine), aiming to boost the immune system against the cancer.
Dallas, TexasAges 18 years+ - NCT06889610RecruitingPhase 2
Ablation plus drug therapy for advanced solid tumors
This trial tests combining a liver tumor ablation procedure with systemic drugs for people with advanced colorectal, breast, or melanoma cancer that has spread to the liver. The goal is to see if this approach can help when standard treatments have stopped working.
ShanghaiAges 18–80 - NCT06305962RecruitingEarly Phase 1
Radioactive drug for advanced PD-L1 positive solid tumors
This trial tests a radioactive medicine (177Lu-anti-PD-L1 sdAb) that delivers radiation to cancer cells with PD-L1 protein, which is found on some solid tumors. It is for people whose cancer has spread or come back after standard treatments.
Kingswood, New South WalesAges 18 years+ - NCT07177937RecruitingPhase 1
Study of DXC014 for advanced solid tumors
This trial tests DXC014, a new drug, in people with advanced solid tumors, including prostate cancer. It aims to see if the drug is safe and effective.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06444815RecruitingPhase 1
Study of VET3-TGI for advanced solid tumors
This trial tests an experimental treatment called VET3-TGI, which is injected directly into tumors. It is for people with advanced solid tumors who have already tried other treatments and are looking for new options.
Los Angeles, CaliforniaAges 18 years+
Hear when a new Melanoma (Skin Cancer) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for melanoma (skin cancer)?
- Yes. Clin2 currently lists 153 recruiting melanoma (skin cancer) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a melanoma (skin cancer) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a melanoma (skin cancer) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.