Clinical trials
Mental Health (Depression) clinical trials
Below are recruiting mental health (depression) clinical trials, each written for real people, not researchers. We’re tracking 308 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06623682Recruiting
Online mental health support for university students
This trial tests a self-help program with support services for students in Hong Kong who are experiencing moderate to severe anxiety or depression. It aims to see if these tools can improve mental health.
Hong KongAges 18 years+ - NCT06582784Recruiting
Using a phone app to help cancer survivors with depression
This study tests a mobile app to help cancer survivors who are feeling depressed. If you have a smartphone and are willing to use an app for mood support, you may be able to join.
Charleston, South CarolinaAges 18 years+ - NCT06456307Recruiting
Stepped care for mood and anxiety during pregnancy
This study tests a step-by-step approach to help pregnant women who are feeling anxious or down. If you are at least 28 weeks pregnant and feeling stressed, worried, or sad, the study will offer you support and check on how you are doing.
NairobiAges 14 years+ - NCT06306092Recruiting
Sleep for better mental health and school grades
This study looks at how helping teenagers sleep better can improve their mental health and school grades. It is open to students in Swedish high schools and upper secondary schools.
Kristianstad, Skåne CountyAges 13–19 - NCT06257095Recruiting
Phone Support Program for Older Adults Leaving APS
This study is testing a phone-based support program for older adults who have been helped by Adult Protective Services and are now moving on. College students in health fields will provide friendly, weekly check-in calls to help with social and emotional needs.
Houston, TexasAges 65 years+ - NCT06087159Recruiting
Mental health toolkit for teachers and caregivers in Uganda
This trial tests if a personalized mobile health toolkit can help teachers and caregivers in Uganda manage stress and support mental health. If you are a teacher or a parent in the study schools, this program may provide tools to improve your wellbeing.
KampalaAges 18 years+ - NCT06071221Recruiting
Mental health program for home health aides
This study tests a program to help home health aides feel better mentally. If you are a home health aide who speaks English or Spanish, has mild depression, high stress, or loneliness, and has at least 1 year of experience, you may be able to join.
New York, New YorkAges 18 years+ - NCT05825040Recruiting
Testing an online mental health program for anxiety and depression
This trial tests an “online” mental health approach to help people with moderate to severe anxiety and/or depression. If you qualify, you may be invited to use the program and share feedback as part of a study.
Shatin, N.T.Ages 17 years+ - NCT05833555Recruiting
Harlem Strong mental health support for adults
This program is for Black and Latino adults in Harlem who are dealing with mild to moderate depression symptoms. It aims to identify people who may benefit from mental health support and connect them with the right level of care.
New York, New YorkAges 18–65 - NCT05824234Recruiting
REFOCUS program for mental health care teams
This trial tests whether a training program for mental health teams improves care for people with certain mental health conditions. You may be included if your clinic/team is using the REFOCUS training and you meet the study language and consent requirements.
Lyon, RhôneAges 15–65 - NCT05763537Recruiting
Study exploring how doulas support pregnancy mood changes
This study looks at how having a doula affects support and wellbeing for people experiencing pregnancy-related mood and anxiety changes. It may help you and others learn what kind of doula support is most helpful during pregnancy.
Missoula, MontanaAges 18 years+ - NCT05074901Recruiting
Using a health app in France with virtual support
This trial tests whether a digital health app (with “virtual agents,” like guided prompts/support) can improve people’s health outcomes. You may help the study by using the app and completing its questionnaires.
BordeauxAges 18 years+ - NCT06997549Recruiting
Review of mental health treatment outcomes
This study looks back at information from a large database of people who received mental health treatments. It aims to understand how well treatments worked and what factors influenced outcomes.
Malvern, PennsylvaniaAges 5–100 - NCT05426057Recruiting
Mental health support for Hispanic teens with caregiver involvement
This study looks at improving mental health in primary care by involving both a teen and an adult caregiver. It may help families who are struggling with communication, depression or anxiety symptoms, or past suicidal thoughts or behaviors.
Miami, FloridaAges 12–16 - NCT06379074Recruiting
Sleep in pregnancy and postpartum mental health
This study looks at how poor sleep during pregnancy might affect stress and mental health after childbirth. It aims to help new mothers by understanding these links.
Bologna, BolognaAges 18 years+ - NCT04569448RecruitingPhase 3
Brexpiprazole for bipolar depression that won’t improve
This Phase 3 study tests whether brexpiprazole can help treat bipolar depression that has not responded to previous treatments. It compares the study medicine to a placebo (inactive pill) for people with bipolar I or II depression.
Hamilton, OntarioAges 18–75 - NCT07216638Enrolling by invitation
Better mental health care for kids in primary care
This trial studies how to better integrate mental health care into pediatric primary care clinics across Indiana. It involves surveys, interviews, and looking at patient records to understand and improve care for children.
Indianapolis, IndianaAges 5 years+ - NCT06284551Enrolling by invitation
Youth internet use and mental health study
This study looks at how internet use relates to mental health in young people aged 15 to 24. It compares healthy individuals with those diagnosed with depression, anxiety, PTSD, or adjustment disorder.
TaipeiAges 15–24 - NCT07044154Recruiting
Sun Tai Chi for heart, lung, and mental health in college students
This trial tests whether a gentle Sun-style Tai Chi program can improve your heart and lung fitness as well as your mental well-being if you have mild to moderate stress, anxiety, or depression. It's for university students who are not already very active and who are not taking mental health medicines.
Talca, Maule RegionAges 18–29 - NCT06455397Recruiting
Building emotional awareness and mental health for parents
This trial tests a program called BEAM that helps parents and caregivers of young children (ages 2–5) manage stress, depression, anxiety, or anger. You'll get support from a peer coach through check-ins and learn skills to feel better.
Winnipeg, ManitobaAges 18 years+ - NCT06511908RecruitingPhase 2
Testing a new ketamine-like drug for hard-to-treat depression
This study tests a new experimental drug (2R,6R)-HNK, a chemical related to ketamine, given by IV infusion to see if it can help people with depression that hasn't improved with other treatments. The goal is to find a new option for people who have not found relief from standard antidepressants.
Bethesda, MarylandAges 18–70 - NCT06659315Recruiting
Preventing HIV transmission from mom to baby for depressed mothers in Malawi
This study tests a program to help pregnant women with HIV who also have depression, and their partners, reduce the risk of passing HIV to their babies. The program includes support for mental health and HIV care.
ZombaAges 18 years+ - NCT04685148RecruitingPhase 1/Phase 2
Study of mental health treatment during pregnancy
This trial studies a treatment aimed at improving maternal mental health during pregnancy. It focuses on people who have had depression around pregnancy before, and checks whether the approach is safe and helpful for them.
CopenhagenAges 18–45 - NCT06722287Recruiting
Phone support for family caregivers in Thailand
This study tests a mobile program to support the mental health of family caregivers in Thailand. You participate from home using your phone.
BangkokAges 18–80
Hear when a new Mental Health (Depression) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for mental health (depression)?
- Yes. Clin2 currently lists 308 recruiting mental health (depression) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mental health (depression) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mental health (depression) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.