Clinical trials
Mental Health (Depression) clinical trials
Below are recruiting mental health (depression) clinical trials, each written for real people, not researchers. We’re tracking 315 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06324864Recruiting
START NOW Adapted for migrant teens, ages 14-18
This trial tests a culturally adapted version of a program called START NOW. It's designed to help teenagers who are migrants in Switzerland and are feeling depressed or very stressed learn new skills to feel better.
Basel, Canton of Basel-CityAges 14–18 - NCT07183748RecruitingPhase 2
Psilocybin microdosing plus therapy for hard-to-treat depression
This trial tests whether taking very small, repeated doses of psilocybin (a substance found in magic mushrooms) along with talk therapy can help people with depression that hasn't gotten better with other treatments. You'll need to stop your current depression medications and avoid drugs or alcohol for the study period.
BeershebaAges 18–65 - NCT05485701Recruiting
Study of perinatal mental health in India
This study looks at mental health during pregnancy and after birth, and may help improve how these concerns are understood and assessed. You may be interviewed or asked to complete surveys across a few visits, depending on which part of the study you join.
Kangra, Himachal PradeshAges 18–45 - NCT06996067Recruiting
Parent coaching texts after first baby in Nova Scotia
This trial tests a text message program to support new parents after childbirth. It aims to help you feel more confident and connected during the early weeks at home.
Halifax, Nova ScotiaAges 18 years+ - NCT06566937Recruiting
E-health program for mental health in breast cancer
This trial tests if an online program can improve mental health for breast cancer patients. It is designed for people currently receiving treatment at Institut Kanser Negara in Malaysia.
PutrajayaAges 18–65 - NCT03388606Recruiting
Studying adolescent depression and how to treat it
This study looks closely at how depression shows up in teens and tests approaches to treatment. It may help teens and families better understand depression and get access to structured care as part of research.
Los Angeles, CaliforniaAges 11–25 - NCT06702722Recruiting
Therapy and HIV support for moms in Malawi
This study tests if combining problem-solving therapy with HIV care support can improve mental health and HIV outcomes for pregnant women living with HIV in Malawi who have elevated depressive symptoms.
LilongweAges 18 years+ - NCT03601026Recruiting
Genetic counseling for youth using cannabis safely
This study offers genetic counseling to help reduce mental health problems that can happen for some young people who use cannabis. You join if you are already part of the FORBOW study and fit their age and mental-health criteria.
Halifax, Nova ScotiaAges 12–21 - NCT05555875Recruiting
Study how people engage with digital mental health tools
This study looks at what helps (or prevents) people from using digital mental health programs. You may join if you have meaningful depression and/or anxiety symptoms and you can use a smartphone for the study apps.
Boston, MassachusettsAges 18–75 - NCT05838404Recruiting
Program to support mental health during early pregnancy
This study tests an intervention meant to improve mental health for people during pregnancy, starting in the first part of pregnancy. You might be able to join if you are already receiving prenatal care and speak English or Spanish.
New Orleans, LouisianaAges 18 years+ - NCT06038721Recruiting
Unified Protocol for kids with emotional concerns
This trial tests a program called Unified Protocol for children ages 7–17 who have emotional difficulties like anxiety, depression, trauma, or obsessive-compulsive symptoms. It aims to help kids and their parents learn skills to manage these feelings together.
Coral Gables, FloridaAges 7–17 - NCT06197711Recruiting
PRISMA for mental health in pretrial detention
This study tests whether a program called PRISMA can help improve mental health for people in pretrial detention. It is designed for detainees in Zurich and Bern who speak one of nine languages and are not in immediate crisis.
Zurich, Canton of ZurichAges 18 years+ - NCT06248203Recruiting
Teacher-led mental health support for teens in Darjeeling
This trial tests a program in which teachers get extra training to support students with emotional or behavioral challenges in low-cost private schools in Darjeeling. It aims to see if teachers can make a positive difference for these teens.
Darjeeling, West BengalAges 13 years+ - NCT06587230Recruiting
Tealeaf-NC: Teacher-led support for students in North Carolina
This study tests the Tealeaf program, where teachers and school staff work together to support students who may be struggling emotionally or behaviorally. It aims to help students in kindergarten through 8th grade who have elevated scores on a behavior and emotions questionnaire.
Chapel Hill, North CarolinaAges 5–99 - NCT07369752Recruiting
Breathing exercises for teens with depression or anxiety
This study looks at whether breathing exercises can help improve brain health and mental well-being in teens with depression or anxiety. It is designed for adolescents who are already receiving care at a Mayo Clinic psychiatry clinic.
Albert Lea, MinnesotaAges 12–17 - NCT00024635Recruiting
Understanding Mood and Anxiety Disorders Study
This research study evaluates people with mood disorders (like depression or bipolar disorder), anxiety disorders, or people without these conditions to better understand how these conditions develop and affect the brain. Researchers will ask questions and may do other assessments to learn more.
Bethesda, MarylandAges 3–99 - NCT04610697Recruiting
Cognitive training for people in forensic mental health care
This trial studies whether a structured “cognitive remediation” program (training thinking skills) can help people receiving care on a forensic treatment unit. It may benefit those who want support improving attention, memory, or problem-solving as part of their treatment.
Ottawa, OntarioAges 18–55 - NCT07226323Recruiting
WeCare for mental health and medication adherence in South Africa
This trial tests a counselling program called WeCare to help men who have sex with men in Johannesburg stick to their HIV or PrEP medication and manage depression symptoms. It is designed for those who are struggling with adherence or have unsuppressed HIV.
JohannesburgAges 18 years+ - NCT07290127Enrolling by invitation
A computer game for mental health after emergency C-section
This trial tests if a computer game can help improve emotional well-being after an emergency cesarean birth. Participants play the game within 24 hours of delivery to see if it reduces mental health risks.
Kyoto, Sakyo-kuAges 20 years+ - NCT06795347Recruiting
Online parenting support for mothers with mental health challenges
This trial tests an online video coaching program (VIPP-SD) to help mothers with serious mental health conditions build a strong bond with their child. The goal is to improve the child's wellbeing and resilience. It compares the program to the usual support that families already receive.
Odense C, Region SyddanmarkAges 1–3 - NCT05965310Recruiting
Virtual psychology support for ACL repair recovery
This study tests a virtual (online) psychological program to help people recover after ACL ligament surgery. It focuses on first-time ACL repairs and aims to improve how patients cope during recovery.
Detroit, MichiganAges 13 years+ - NCT06567496Enrolling by invitation
Virtual reality for mental health and success in PT students
This study tests whether using virtual reality (VR) can help Physical Therapy students feel better mentally and do better in school. If you are a PT student at Belmont University and free from certain health issues that VR might affect, you may be able to join.
Nashville, TennesseeAges 18 years+ - NCT06248762Recruiting
App for parents: PPI and mindfulness for kids with NDD
This trial tests a digital app that combines PPI (positive psychology exercises) and mindfulness for parents of children with or suspected of a neurodevelopmental disorder (NDD). It aims to help you manage stress and feel better through daily use for about 15 minutes.
EnschedeAges 18 years+ - NCT06409325Recruiting
Magnetic Seizure vs. Electric Shock for Depression
This study compares two brain stimulation treatments—Magnetic Seizure Therapy (MST) and Electroconvulsive Therapy (ECT)—to see which works better for severe depression. If you are on a stable antidepressant and haven't had recent brain stimulation, this trial may be an option for you.
Shanghai, Shanghai MunicipalityAges 18–65
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Common questions
- Are there clinical trials for mental health (depression)?
- Yes. Clin2 currently lists 315 recruiting mental health (depression) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mental health (depression) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mental health (depression) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.