Clinical trials
Metabolically Healthy Obesity clinical trials
Below are recruiting metabolically healthy obesity clinical trials, each written for real people, not researchers. We’re tracking 61 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04873258Recruiting
Test a non-invasive tool to screen for fat-related liver disease
This study looks at a new non-invasive screening method to predict metabolic dysfunction–associated steatotic liver disease (MASLD), a condition where fat builds up in the liver. The goal is to help identify people who may be at risk without needing invasive tests.
London, LondonAges 18–80 - NCT07673900RecruitingPhase 1
Testing a new patch for semaglutide in healthy overweight adults
This trial tests a new skin patch (VX-201) that delivers semaglutide, a medicine used for weight management, compared to a standard injection. It is for healthy overweight or obese adults who are not taking other weight loss medications.
Tempe, ArizonaAges 18–60 - NCT07248371Recruiting
Validating multi-omics for metabolic syndrome diseases
This study is testing a new way to look at health information (multi-omics) to better understand conditions related to metabolic syndrome, like diabetes or heart disease. It may help doctors find more personalized treatments.
TaoyuanAges 20 years+ - NCT06511297Recruiting
How aging and weight affect health: a deep-dive study
This study looks at how aging and body weight affect health and metabolism. Researchers will collect detailed measurements (like scans and blood tests) to understand why some people age better than others. You may join if you are in one of five age/weight groups.
Vienna, State of ViennaAges 18 years+ - NCT06223555Recruiting
Mixed meal energy study in healthy adults
This study looks at how your body responds to a mixed meal (a test drink or meal) when the calories are either fixed or adjusted to your energy needs. It may help researchers understand how to measure metabolism more accurately.
Phoenix, ArizonaAges 18–99 - NCT05653258RecruitingPhase 2/Phase 3
Study cells in fat tissue and aging cells in older adults
This study uses a special lab test on tiny samples from body fat to map different cell types and “senescent” (aging) cells. It may help researchers understand how aging and obesity are linked, which could guide future treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT07463196RecruitingPhase 1
Study of ACI-19764 for healthy people and those with heart risks
This trial tests an experimental drug called ACI-19764 to see how safe it is, how the body handles it, and how it affects the immune system. It's for healthy adults and for adults with heart-related risk factors like obesity or type 2 diabetes.
GroningenAges 18–75 - NCT07363148Recruiting
Study of MB-1 for weight and metabolic health in overweight adults
This study tests a new supplement called MB-1 to see if it can improve metabolic health in adults who are overweight or obese. If you are between 18 and 50, have a certain waist size, and have been at a stable weight for the last 3 months, you may qualify.
London, OntarioAges 18–50 - NCT07702890RecruitingPhase 1/Phase 2
Testing a new drug for obesity and type 2 diabetes
This trial tests an investigational drug called GUB-UCN2 in people who are healthy, overweight, or have type 2 diabetes. The goal is to see if the drug is safe and how the body processes it.
NeussAges 18–75 - NCT06891287RecruitingPhase 1
Testing an oral GLP-1/2 capsule in healthy volunteers
This study tests a new oral capsule that delivers a medicine called PG-102, which is a dual GLP-1/2 agonist (similar to drugs used for diabetes and weight loss). It is for healthy volunteers to see how the body handles the medicine. The study has two parts: one for people with a lower BMI and one for people with a higher BMI (over 30).
Melbourne, VictoriaAges 18–65 - NCT07246408Recruiting
Cottonseed oil study for heart health
This study tests how taking cottonseed oil at certain times affects heart disease risk. It may help people with high cholesterol or who are overweight.
Athens, GeorgiaAges 25–75 - NCT06382298Recruiting
Cottonseed oil vs. similar oil for heart health
This study compares the effects of cottonseed oil versus a similar oil on heart health. It is for people with high cholesterol or who are overweight and want to see if changing cooking oils can improve their cholesterol levels.
Athens, GeorgiaAges 25–75 - NCT01143454Recruiting
Study unusual heart conditions and related genetic traits
This study looks at people with unusual or rare heart problems, or people with a family history of these issues. Doctors and researchers may collect and study your blood or tissue (and possibly store samples) to learn what causes the condition and how it may affect the heart.
Washington D.C., District of ColumbiaAges 1–100 - NCT05723913Recruiting
Test functional foods on blood sugar and gut bacteria
This study looks at how eating specific functional foods affects blood sugar after meals and changes in gut bacteria. It may help people understand ways to support healthy blood sugar and digestion, but it’s not for people with diabetes.
Mexico City, Mexico CityAges 18–60 - NCT06562907RecruitingPhase 1
Study of an experimental drug for weight and diabetes
This study tests an investigational drug called GS-4571 in healthy people, people with obesity, and people with type 2 diabetes. It aims to see how the drug affects the body and whether it might help with weight and blood sugar control.
Miami, FloridaAges 18–65 - NCT06482944Recruiting
Whole-food diet program for families to prevent type 2 diabetes
This 12-week program helps parents with prediabetes and their children eat healthier whole foods based on U.S. dietary guidelines. The goal is to see if the program can lower the risk of developing type 2 diabetes in the family.
Nashville, TennesseeAges 6–59 - NCT05632406Recruiting
Breathing training to improve breathing and blood pressure
This study tests whether a breathing device training program can improve breathing and blood pressure. It may help people who have higher blood pressure and may feel out of breath, especially those who have weight-related breathing strain.
Tallahassee, FloridaAges 18–45 - NCT05545306Recruiting
Study tests how extra calories change your daily energy use
This study looks at how eating more calories affects your body’s natural heat production and total energy use over a full day. It may help researchers better understand how the body manages weight and energy.
Phoenix, ArizonaAges 18–60 - NCT04634591Recruiting
Weight-loss surgery study for people with severe obesity
This trial studies bariatric (weight-loss) surgery and how well it helps people reach and keep a healthier weight. You may qualify if you have severe obesity and have not been able to maintain weight loss with other attempts, and if you can safely follow the study plan.
Bialystok, Podlaskie VoivodeshipAges 18 years+ - NCT07844616Recruiting
Eggs, gut health, and metabolism study
This study looks at how eating whole eggs versus egg whites affects your gut bacteria, metabolism, and immune system. It aims to understand how eggs may influence health markers in people of different weight ranges.
Storrs, ConnecticutAges 18–50 - NCT07165431Recruiting
Postbiotic supplement study for overweight and obesity
This study tests whether taking a daily postbiotic gummy for 12 weeks can improve body composition and metabolic health in people with overweight or obesity. It may help if you have stable weight and no major health conditions like diabetes.
Pamplona, NavarreAges 18–70 - NCT06226194Recruiting
Genes and weight loss after bariatric surgery
This study looks at how your genes might affect how much weight you lose after gastric sleeve or gastric bypass surgery. You may be able to help doctors better predict weight loss results for future patients.
Lleida, LeidaAges 18–65 - NCT06859853RecruitingPhase 1
MWN109 injection safety study in healthy volunteers
This trial tests an investigational injection called MWN109 to see if it is safe and how the body processes it. It is for healthy adults only, and the results will help decide if the drug should be tested in people with medical conditions.
Melbourne, VictoriaAges 18–50 - NCT05945537RecruitingPhase 1
Testing INI-822 in healthy people and those with MASH
This study tests a new oral medication (INI-822) to see if it’s safe and how the body handles it in healthy volunteers and in people with MASH. MASH is a type of fatty liver disease with inflammation and possible scarring. If you have MASH, the study also checks if the drug can improve markers of liver health. You will need to come to the study site for visits and follow strict guidelines about birth control, alcohol, and other medicines.
Camperdown, New South WalesAges 18–70
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Common questions
- Are there clinical trials for metabolically healthy obesity?
- Yes. Clin2 currently lists 61 recruiting metabolically healthy obesity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metabolically healthy obesity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metabolically healthy obesity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.