Clinical trials
Metabolically Healthy Obesity clinical trials
Below are recruiting metabolically healthy obesity clinical trials, each written for real people, not researchers. We’re tracking 65 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07654972RecruitingPhase 1
Study of a new weight loss drug in healthy people with obesity or overweight
This study tests a new medication (LY4174794) for weight loss in people who are overweight or have obesity. It will help see if the drug is safe and how the body processes it.
San Antonio, TexasAges 18–65 - NCT06824974Recruiting
Time-restricted eating for liver disease or cancer
This study tests whether combining time-restricted eating with healthy eating helps people with metabolic liver disease, cirrhosis, or early-stage liver cancer. If you are overweight and currently fast less than 12 hours at night, this diet approach might improve your health.
La Jolla, CaliforniaAges 18 years+ - NCT04873258Recruiting
Test a non-invasive tool to screen for fat-related liver disease
This study looks at a new non-invasive screening method to predict metabolic dysfunction–associated steatotic liver disease (MASLD), a condition where fat builds up in the liver. The goal is to help identify people who may be at risk without needing invasive tests.
London, LondonAges 18–80 - NCT07013643RecruitingPhase 1
How a new weight-loss drug affects birth control pills
This study checks if a new weight-loss medicine changes how the body handles birth control pills. It is for healthy women with overweight or obesity.
Glendale, CaliforniaAges 35–75 - NCT07673900RecruitingPhase 1
Testing a new patch for semaglutide in healthy overweight adults
This trial tests a new skin patch (VX-201) that delivers semaglutide, a medicine used for weight management, compared to a standard injection. It is for healthy overweight or obese adults who are not taking other weight loss medications.
Tempe, ArizonaAges 18–60 - NCT06982131RecruitingPhase 1
Safety of RO7795081 and its effect on two statins
This study tests a new drug called RO7795081 to see if it changes how your body handles two common statins (pitavastatin and rosuvastatin). It is for adults who are overweight or obese but otherwise healthy, and aims to check the safety of the new drug.
GroningenAges 18–65 - NCT07248371Recruiting
Validating multi-omics for metabolic syndrome diseases
This study is testing a new way to look at health information (multi-omics) to better understand conditions related to metabolic syndrome, like diabetes or heart disease. It may help doctors find more personalized treatments.
TaoyuanAges 20 years+ - NCT06511297Recruiting
How aging and weight affect health: a deep-dive study
This study looks at how aging and body weight affect health and metabolism. Researchers will collect detailed measurements (like scans and blood tests) to understand why some people age better than others. You may join if you are in one of five age/weight groups.
Vienna, State of ViennaAges 18 years+ - NCT07407348RecruitingPhase 1
Comparing Two Forms of Survodutide in People with Overweight or Obesity
This trial compares how two different forms of the study drug survodutide are absorbed by the body in people with overweight or obesity. It helps doctors understand which version works better.
NottinghamAges 18–65 - NCT05653258RecruitingPhase 2/Phase 3
Study cells in fat tissue and aging cells in older adults
This study uses a special lab test on tiny samples from body fat to map different cell types and “senescent” (aging) cells. It may help researchers understand how aging and obesity are linked, which could guide future treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT06223555Recruiting
Mixed meal energy study in healthy adults
This study looks at how your body responds to a mixed meal (a test drink or meal) when the calories are either fixed or adjusted to your energy needs. It may help researchers understand how to measure metabolism more accurately.
Phoenix, ArizonaAges 18–99 - NCT07702890RecruitingPhase 1/Phase 2
Testing a new drug for obesity and type 2 diabetes
This trial tests an investigational drug called GUB-UCN2 in people who are healthy, overweight, or have type 2 diabetes. The goal is to see if the drug is safe and how the body processes it.
NeussAges 18–75 - NCT06891287RecruitingPhase 1
Testing an oral GLP-1/2 capsule in healthy volunteers
This study tests a new oral capsule that delivers a medicine called PG-102, which is a dual GLP-1/2 agonist (similar to drugs used for diabetes and weight loss). It is for healthy volunteers to see how the body handles the medicine. The study has two parts: one for people with a lower BMI and one for people with a higher BMI (over 30).
Melbourne, VictoriaAges 18–65 - NCT06382298Recruiting
Cottonseed oil vs. similar oil for heart health
This study compares the effects of cottonseed oil versus a similar oil on heart health. It is for people with high cholesterol or who are overweight and want to see if changing cooking oils can improve their cholesterol levels.
Athens, GeorgiaAges 25–75 - NCT07246408Recruiting
Cottonseed oil study for heart health
This study tests how taking cottonseed oil at certain times affects heart disease risk. It may help people with high cholesterol or who are overweight.
Athens, GeorgiaAges 25–75 - NCT07349381RecruitingPhase 1
How Food Affects a New Drug, CX11
This study tests how food affects the absorption of a new drug called CX11 in healthy volunteers. The results will help determine if the drug should be taken with or without food.
Shanghai, Shanghai MunicipalityAges 18–45 - NCT01143454Recruiting
Study unusual heart conditions and related genetic traits
This study looks at people with unusual or rare heart problems, or people with a family history of these issues. Doctors and researchers may collect and study your blood or tissue (and possibly store samples) to learn what causes the condition and how it may affect the heart.
Washington D.C., District of ColumbiaAges 1–100 - NCT06562907RecruitingPhase 1
Study of GS-4571 in healthy people, people with obesity, and people with type 2 diabetes
This trial tests an experimental drug called GS-4571 in three groups: healthy individuals, people with obesity (but not diabetes), and people with type 2 diabetes who are not obese. The study aims to see how the drug affects the body and how safe it is.
Miami, FloridaAges 18–55 - NCT04634591Recruiting
Weight-loss surgery study for people with severe obesity
This trial studies bariatric (weight-loss) surgery and how well it helps people reach and keep a healthier weight. You may qualify if you have severe obesity and have not been able to maintain weight loss with other attempts, and if you can safely follow the study plan.
Bialystok, Podlaskie VoivodeshipAges 18 years+ - NCT05545306Recruiting
Study tests how extra calories change your daily energy use
This study looks at how eating more calories affects your body’s natural heat production and total energy use over a full day. It may help researchers better understand how the body manages weight and energy.
Phoenix, ArizonaAges 18–60 - NCT05632406Recruiting
Breathing training to improve breathing and blood pressure
This study tests whether a breathing device training program can improve breathing and blood pressure. It may help people who have higher blood pressure and may feel out of breath, especially those who have weight-related breathing strain.
Tallahassee, FloridaAges 18–45 - NCT05723913Recruiting
Test functional foods on blood sugar and gut bacteria
This study looks at how eating specific functional foods affects blood sugar after meals and changes in gut bacteria. It may help people understand ways to support healthy blood sugar and digestion, but it’s not for people with diabetes.
Mexico City, Mexico CityAges 18–60 - NCT06482944Recruiting
Whole-food diet program for families to prevent type 2 diabetes
This 12-week program helps parents with prediabetes and their children eat healthier whole foods based on U.S. dietary guidelines. The goal is to see if the program can lower the risk of developing type 2 diabetes in the family.
Nashville, TennesseeAges 6–59 - NCT06790225Recruiting
A study on a gut hormone and bone health
This trial looks at how a natural gut hormone (GIP) affects bone remodeling in healthy people. If you are healthy, you may help us understand how this hormone works on bone cells.
EsbjergAges 18–40
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Common questions
- Are there clinical trials for metabolically healthy obesity?
- Yes. Clin2 currently lists 65 recruiting metabolically healthy obesity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metabolically healthy obesity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metabolically healthy obesity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.