Clinical trials
Metabolically Healthy Obesity clinical trials
Below are recruiting metabolically healthy obesity clinical trials, each written for real people, not researchers. We’re tracking 63 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05933707Recruiting
Study tiny vesicles and how they affect insulin
This study looks at how very small particles in the body (“extracellular vesicles”) relate to insulin action and how the body handles sugar. It may help researchers understand why some people have better or worse insulin responses.
St Louis, MissouriAges 25–55 - NCT06799897Recruiting
Healthy obesity natural course study
This study follows people who have obesity but are otherwise metabolically healthy, to see how their health changes over time. You may qualify if your blood pressure, blood sugar, and cholesterol are normal.
BadenAges 18–60 - NCT07095426Recruiting
Fiber supplement study for gut and blood vessel health
This study tests whether taking a fiber supplement can improve gut health and blood vessel health in people with obesity. It may help you understand how your body responds to extra fiber.
Muncie, IndianaAges 18–55 - NCT07330297Recruiting
Breath test for metabolic syndrome and obesity health
This study uses a breath test to see if it can tell the difference between people with metabolic syndrome, those with obesity but otherwise healthy, and healthy controls. It aims to find a simple way to check metabolic health without blood draws.
MoscowAges 18 years+ - NCT07559227Recruiting
How obesity affects gut health and blood vessel function
This study compares people with normal weight to people with obesity who are otherwise healthy to understand how body weight affects gut bacteria, immune function, and blood vessel health. Results may help explain why some people with obesity stay healthier than others.
Muncie, IndianaAges 18–55 - NCT07001865Enrolling by invitation
Effects of healthy obesity on liver and uric acid risks
This study looks at people who are metabolically healthy but overweight or obese, and how that affects their risk of developing fatty liver disease (MASLD) or high uric acid levels (hyperuricemia). It aims to see if 'healthy' obesity still carries hidden health risks.
NingboAges 18–100 - NCT07340125Recruiting
Pistachio snacking and metabolic flexibility study
This study tests whether eating pistachios as a snack can improve how your body uses energy and manages metabolism. It looks at people who are overweight, sleep poorly, and don't exercise much.
Columbia, South CarolinaAges 25–45 - NCT04735835Recruiting
Personalized diet testing using ZOE app and blood samples
This trial studies how different food compositions affect your body, using the ZOE testing program plus meals you eat and blood samples you collect. It may help you learn more about what foods work best for you, especially if you have a long-term health condition.
Needham, MassachusettsAges 18 years+ - NCT06363253Recruiting
Gut bacteria study in obesity and muscle loss
This study looks at the bacteria in your gut (the microbiome) to understand how they relate to obesity and muscle loss. Researchers will collect stool samples to analyze the gut bacteria, which may help find new ways to treat metabolic diseases.
SingaporeAges 21–99 - NCT07511205RecruitingPhase 1
Study of AZD1043 for overweight or obesity
This trial tests a new medicine called AZD1043 in healthy adults who are overweight or have obesity. It aims to see if the medicine is safe and how the body handles it.
Glendale, CaliforniaAges 18–65 - NCT06335771Recruiting
Study on fat metabolism in obesity and diabetes
This study looks at how fat is processed in the body for people with different health conditions, including obesity and type 2 diabetes. It aims to find new ways to improve treatment by understanding these differences.
Columbia, MissouriAges 18–70 - NCT07361887Recruiting
Moderate wine and healthy aging study
This study tests whether moderate wine consumption can help healthy aging by looking at tiny particles in your blood after a meal. It may help you understand how wine affects your body's cells.
Seville, SevillaAges 35–36 - NCT06338631Recruiting
Early kidney check in people with excess weight
This study looks for early signs of kidney problems in people with excess weight, even if they are otherwise healthy. It aims to understand how weight affects kidneys before any disease develops.
MilanAges 18–60 - NCT01399385Recruiting
MRI and heart scans to test possible heart disease
This study tests new or improved heart imaging methods to understand whether people have heart-related blood vessel disease. It may help by comparing scan results to your health history and other testing to better spot heart problems earlier.
Bethesda, MarylandAges 18–100 - NCT06252220RecruitingPhase 1
Testing a new drug for obesity in healthy adults
This trial tests a new medication called DA-1726 for people with obesity but no other major health problems. It aims to see if the drug is safe and how it works in the body. You may qualify if your body mass index (BMI) is between 30 and 45 and your weight has been stable for 3 months.
Miami, FloridaAges 18–65 - NCT07578584RecruitingPhase 1
Safety study of NNC0497-0040 in healthy and overweight adults
This early-stage study tests a new investigational medication in three groups: healthy adults with normal weight, adults who are overweight or obese, and men with type 1 diabetes who are also overweight. The research aims to understand how safe the medication is and how the body processes it.
NeussAges 18–55 - NCT06571474Recruiting
Fat Cell Function in Obesity and Metabolism Study
This study looks at how a type of immune cell (macrophage) in fat tissue processes lipids, and how that affects metabolism in people with different body weights. It may help us understand why some people with obesity develop diabetes and fatty liver while others do not.
Columbia, MissouriAges 18–70 - NCT07209202Recruiting
Study on Fructose Handling in Obesity
This study looks at how the body handles fructose (a natural sugar) in people with different weights. It may help explain why some people process sugars differently.
Vallejo, CaliforniaAges 20–55 - NCT05554016Recruiting
Ultra-processed food study in kids with obesity
This study looks at how eating ultra-processed foods affects metabolism and body weight in children and teens with obesity, and compares them with healthy peers. Your participation may help scientists understand whether diet choices contribute to weight and metabolic problems.
NaplesAges 6–18 - NCT05745441Recruiting
Dinner routine study for weight and prediabetes health
This study tests whether changing your dinner timing and routine can improve health related to weight and blood sugar in people with obesity and prediabetes (or healthy weight). You’ll follow a set dinner schedule and complete study visits while the team monitors outcomes.
Baltimore, MarylandAges 18–50 - NCT06464497Recruiting
Whole foods for teens with obesity pilot study
This study tests whether replacing processed foods with whole foods (like fruits, vegetables, and whole grains) for 8 weeks can help reduce body fat in teens with obesity. Both the teen and a parent or caregiver will learn to prepare and eat healthier meals together.
Nashville, TennesseeAges 10 years+ - NCT07392905Recruiting
How the brain and body respond to food in obesity
This study looks at how your brain and body respond to food based on your weight. You'll eat a standard meal and have brain scans (MRI) to see how your brain reacts.
Nanjing, JiangsuAges 18–40 - NCT07654972RecruitingPhase 1
Study of a new weight loss drug in healthy people with obesity or overweight
This study tests a new medication (LY4174794) for weight loss in people who are overweight or have obesity. It will help see if the drug is safe and how the body processes it.
San Antonio, TexasAges 18–65 - NCT06824974Recruiting
Time-restricted eating for liver disease or cancer
This study tests whether combining time-restricted eating with healthy eating helps people with metabolic liver disease, cirrhosis, or early-stage liver cancer. If you are overweight and currently fast less than 12 hours at night, this diet approach might improve your health.
La Jolla, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for metabolically healthy obesity?
- Yes. Clin2 currently lists 63 recruiting metabolically healthy obesity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metabolically healthy obesity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metabolically healthy obesity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.