Clinical trials
Microbiome clinical trials
Below are recruiting microbiome clinical trials, each written for real people, not researchers. We’re tracking 350 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05916755Recruiting
Testing tumor clues that predict response to immunotherapy
This study looks for “biomarkers,” or tumor clues, that may help predict who benefits from checkpoint inhibitor immunotherapy in triple-negative breast cancer. It may help doctors choose the right treatment approach in the future, especially when chemotherapy is planned.
BarcelonaAges 18 years+ - NCT05931718Recruiting
Track diagnosis and treatment in autoimmune blood count disorders
This study follows adults with autoimmune blood problems like autoimmune hemolytic anemia, immune thrombocytopenia, and autoimmune/neutropenia to see how diagnosis and care work over time. You may be asked to complete follow-up visits for up to 3 years.
MilanAges 18 years+ - NCT05934188Recruiting
Study how gut signals relate to brain aging and diseases
This study looks at how the gut may influence the brain in normal aging and conditions like Alzheimer’s, Parkinson’s, and multiple sclerosis. It may help researchers understand new ways to measure or treat these brain changes over time.
Venice-Lido, VeniceAges 20–90 - NCT05972317Recruiting
Study gut bacteria in IBS patients with and without treatment
This study looks at stool (poop) samples to understand differences in gut bacteria in people with irritable bowel syndrome (IBS), depending on whether they’ve had treatment. It may help researchers find better ways to explain IBS and improve care.
RehovotAges 18–70 - NCT06009276Recruiting
Gut bacteria, muscle blood flow, and fitness study
This study looks at how the bacteria in your gut affect blood flow to your muscles and your overall fitness. You will provide samples and do some exercise tests to help researchers understand this link.
Charlottesville, VirginiaAges 18 years+ - NCT06044051Recruiting
Severe infant asthma and the lung microbiome study
This study looks at the bacteria (microbiome) in the airways of infants under 2 years old with severe asthma. It aims to understand how these bacteria might affect the disease.
RouenAges Up to 2 years - NCT06048614Recruiting
Saline enema for meconium blockage in premature babies
This trial tests if giving a saline enema helps premature babies with meconium blockage pass stool, start feeding, and improve gut and brain health. It may reduce complications and help babies grow better.
SingaporeAges 1 day–8 months - NCT06050733Recruiting
Gut bacteria and immunotherapy response in solid tumors
This study looks at how the bacteria in your gut may affect how well immunotherapy works for solid cancers that have spread or cannot be removed. It focuses on people who have been on certain immunotherapy drugs (PD-1 or PD-L1 inhibitors) for at least 3 months but less than 2 years.
Galveston, TexasAges 35–75 - NCT06051201Recruiting
ReceptIVFity test for IVF success prediction
This trial studies a vaginal swab test called ReceptIVFity that looks at the bacteria in your vagina to see if it can help predict how well IVF will work. You can join if you're about to start your first IVF cycle, are not on hormonal birth control or antibiotics, and your IVF is not for emergency reasons.
RotterdamAges 18–42 - NCT06051318Recruiting
Diet and gut microbiome effects on blood sugar in healthy adults
This study looks at how your gut bacteria and the foods you eat affect your blood sugar after meals. You'll wear a small sensor to track your blood sugar for 10 days and provide stool samples.
Florianópolis, Santa CatarinaAges 18–60 - NCT06072976Recruiting
How feeding affects gut health in babies with bowel conditions
This study looks at whether breast milk or formula helps babies with certain bowel problems heal faster and reach full feeds sooner. It compares how different milk affects the bacteria in a baby's gut.
Seattle, WashingtonAges birth–55 years - NCT06074250RecruitingPhase 2/Phase 3
Pregnancy, mood, and gut health study
This study tests whether a nutritional supplement can help prevent depression and anxiety during and after pregnancy. It looks at how the mother's gut bacteria may influence mood.
Toronto, OntarioAges 18–43 - NCT06076083Recruiting
Microbiome study in Korean patients with ankylosing spondylitis
This study looks at the bacteria living in your body (the microbiome) in people with ankylosing spondylitis and their close family members. Researchers hope to better understand how these bacteria relate to the disease, which may lead to better treatments in the future.
Seoul, Kyungheedae-ro 23Ages 19–60 - NCT06100211Recruiting
HIV, gut health, and switching HIV meds study
This study looks at how changing your HIV medication affects the bacteria in your gut. You'll provide two stool samples so researchers can see what changes happen.
Manchester, Greater ManchesterAges 18 years+ - NCT06098404Recruiting
Cancer-related thinking and memory changes linked to gut health
This study looks at how gut bacteria might be connected to memory or thinking problems in people with cancer. If you join, you will answer surveys and provide stool samples to help researchers understand this link.
Galveston, TexasAges 18 years+ - NCT06114784Recruiting
Study of microbiome and severe pneumonia with breathing support
This study looks at how bacteria in your body (microbiome) affect how sick you get from severe pneumonia. It may help doctors find better ways to treat people with serious lung infections who need breathing support.
Hangzhou, ZhejiangAges 18 years+ - NCT06117930Recruiting
Brain tumor and gut bacteria study
This study looks at how the bacteria in your gut might be linked to brain tumors. Researchers want to collect samples (like stool and tissue) during brain surgery to better understand this connection.
Jacksonville, FloridaAges 18 years+ - NCT06124833Recruiting
Gut and mouth microbiome study for Korean IBD patients and their family
This study looks at the bacteria in your gut and mouth to understand more about inflammatory bowel disease (IBD). It compares patients with their close family members who do not have IBD to see what might be different.
SeoulAges 13–85 - NCT06136845Recruiting
Esophageal cancer microbiome and leak after surgery
This study looks at bacteria in esophageal cancer tumors and whether certain bacteria are linked to leaks that can happen after surgery to remove the esophagus. It may help doctors understand how to prevent these leaks in the future.
HaifaAges 18–85 - NCT06171360Recruiting
Gut bacteria and CDK4/6 inhibitor treatment in breast cancer
This study looks at how gut bacteria affect response to a type of targeted therapy (CDK4/6 inhibitors) combined with hormone therapy in breast cancer that is hormone receptor-positive and HER2-negative. It may help find out why some people respond better to treatment and could lead to better personalized care.
BrusselsAges 18–100 - NCT06172764RecruitingPhase 4
Vitamin D for early cavities: a saliva study
This study tests whether vitamin D supplements can help improve the health of your mouth by looking at changes in saliva and the bacteria that cause cavities. If you have early cavities and low vitamin D, you may be able to join.
Karachi, SindhAges 12–50 - NCT06177184Recruiting
Donor milk for full-term cesarean-born babies
This study tests whether giving donor breast milk to full-term babies born by C-section can improve their gut health. If your baby was born by C-section and you plan to breastfeed, this trial may be a good fit.
Calgary, AlbertaAges 9 months+ - NCT06186089Recruiting
How stomach surgery affects gut bacteria and your thinking
This study looks at how having stomach cancer surgery changes your gut bacteria and thinking abilities. Researchers want to understand if these changes affect memory or brain function after the operation.
Wuhan, HubeiAges 40–80 - NCT06190847Recruiting
Oral bacteria and response to chemoradiotherapy in esophageal cancer
This study looks at how the bacteria in your mouth might affect how well chemoradiotherapy (a combination of chemotherapy and radiation) works for esophageal cancer that cannot be removed by surgery. The goal is to see if the oral microbiome can predict treatment response.
Hefei, AnhuiAges 18–85
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Common questions
- Are there clinical trials for microbiome?
- Yes. Clin2 currently lists 350 recruiting microbiome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a microbiome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a microbiome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.