Clinical trials
Microbiome clinical trials
Below are recruiting microbiome clinical trials, each written for real people, not researchers. We’re tracking 349 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05337072Recruiting
Finding the cause of chronic endometritis in IVF patients
This study looks for a possible infection-related cause of chronic endometritis (a long-lasting inflammation inside the uterus) in people preparing for IVF/ICSI, to help find the best treatment. It involves a diagnostic hysteroscopy and may help doctors choose the most effective steps to improve pregnancy chances.
BrusselsAges Any age - NCT05353504Recruiting
Testing how gut changes affect food choices
This study looks at whether interventions that change your gut bacteria can change how you decide what to eat. It may help researchers understand the gut–brain link behind eating behavior.
LeipzigAges 18–60 - NCT05357170Recruiting
Testing gut bacteria changes after severe ICU illnesses
This study looks at changes in the microbiome (gut bacteria) in adults after serious ICU illnesses like sepsis, major trauma, or open heart/abdominal surgery. It may help researchers understand why recovery can be harder in some people and guide future treatments.
Gainesville, FloridaAges 18–110 - NCT05359796Recruiting
Study of long-term type 1 diabetes symptoms and characteristics
This study looks at what day-to-day health and medical features are like in people who have had type 1 diabetes for many years. It may help researchers better understand long-term needs in type 1 diabetes and guide future care.
Changsha, HunanAges Any age - NCT05381792Recruiting
Test of gut bacteria changes after colon tumor removal
This study looks at how the gut’s bacteria and bacterial gene signals change after doctors remove certain advanced growths in the colon using endoscopy. If you need an endoscopic procedure for an advanced adenoma or early colon cancer, your stool/bacteria samples may help researchers understand what changes after treatment.
Shatin, New TerritoriesAges 18–90 - NCT05414409RecruitingPhase 2
Gut microbiome study in young people with type 1 diabetes
This Phase 2 study looks at the gut microbiome (the bacteria in your intestines) in youth with type 1 diabetes, and how metformin may work differently through the gut. It may help researchers understand mechanisms and future treatment options.
Indianapolis, IndianaAges 11–18 - NCT05414994Recruiting
Study eye bacteria in healthy and eye disease
This study compares the tiny living organisms (“ocular microbiome,” meaning eye-surface bacteria) in different eye conditions. It may help researchers understand how these eye bacteria relate to diseases and why some people develop problems with vision.
Nashville, TennesseeAges 18 years+ - NCT05445544Recruiting
Study of belly and baby microbes to improve preeclampsia screening
This study looks at tiny living organisms in pregnancy (and related body samples) to find better ways to screen for preeclampsia. By learning early warning signs, it may help doctors identify risk sooner during routine prenatal care.
Guangzhou, GuangdongAges 18 years+ - NCT05462496RecruitingPhase 2
Pembrolizumab plus gut microbiome changes after pancreatic chemo
This Phase 2 study tests whether changing the gut microbiome (the gut’s helpful bacteria) and giving pembrolizumab after chemotherapy can improve outcomes for people with operable pancreatic cancer. It aims to see if this approach can boost the immune system after standard treatment and help reduce cancer returning.
New York, New YorkAges 19 years+ - NCT05603650Recruiting
Mouthwash study for healthy bacteria in your mouth and gut
This study tests how a mouthrinse changes the helpful bacteria in your mouth and stomach/gut. You may need several visits and phone follow-ups to see how your microbiome shifts over time.
Irvine, CaliforniaAges 18 years+ - NCT05640700Recruiting
Study of vaginal microbiome in HPV-related early cell changes
This study looks at the vaginal “microbiome” (the normal germs and bacteria in the vagina) in people who have had abnormal Pap smear or colposcopy results related to HPV. It may help doctors understand what to monitor and how to better identify early, pre-cancer changes in the cervix.
JerusalemAges 25–70 - NCT05655910Recruiting
Nutrition support program for people with LVADs in the hospital
This trial tests whether an enhanced nutrition plan can improve care for adults who already have an LVAD (a heart pumping device). It’s designed for hospitalized patients and looks at who can safely eat by mouth while avoiding high-risk situations.
New York, New YorkAges 18 years+ - NCT05689255Recruiting
Study gut bacteria and gut chemistry after gallbladder treatment
This study looks at how your gut bacteria and gut chemical products change after treatment for gallstones. It may help researchers understand what drives symptoms and recovery after surgery and/or endoscopic procedures.
Singapore, SingaporeAges 21–80 - NCT05706922Recruiting
Study gut and vaginal bacteria in PCOS women
This study looks at differences in gut and vaginal bacteria in people with PCOS (a hormone-related condition). You may help researchers understand what bacterial patterns are linked to PCOS and why that might matter for symptoms.
Rotterdam, South HollandAges 18–45 - NCT05732480Recruiting
Studying how gut bacteria affect gallstone disease
This study looks at gut bacteria (your microbiome) in people with gallstones to better understand what’s going on in the body. It includes adults having gallbladder removal surgery, and it may help researchers find better ways to predict or treat gallstone disease.
Ashford, KentAges 18 years+ - NCT05753813RecruitingEarly Phase 1
Study lactic acid gel to change vaginal germs
This early study tests whether placing a lactic acid gel inside the vagina can change the vaginal “microbiome,” the mix of germs, to help reduce repeat BV or yeast infections. You may join if you’ve had at least two recent episodes that needed treatment.
Honolulu, HawaiiAges 18–54 - NCT05754645Recruiting
Study of gut microbiome in weight-related pregnancy outcomes
This study looks at differences in the gut’s living microbes (microbiome) in people who are trying to conceive or are early in pregnancy, and how that may relate to pregnancy outcomes. It may help researchers understand whether microbiome changes are linked to healthier—or more complicated—pregnancies.
Rotterdam, South HollandAges 18–45 - NCT05795257Recruiting
Studying lung immune cells and gut microbes in ARDS
This trial studies how immune cells in the lungs and gut microbes (your microbiome) change during ARDS and how these changes relate to your outcomes. It may help researchers better predict and treat ARDS by learning what’s going on in the lungs and body systems.
HvidovreAges 18 years+ - NCT05835206RecruitingPhase 2
Drug to reduce antibiotic-resistant gut bacteria
This Phase 2 study tests whether an investigational treatment can help clear or reduce antibiotic-resistant bacteria living in the gut. It may help prevent these germs from causing future infections by targeting specific resistant bacteria found on stool or rectal swabs.
Atlanta, GeorgiaAges 18 years+ - NCT05837221Recruiting
Study of the mouth microbiome in oral cancer
This study looks at the types of bacteria in the mouth (the microbiome) in people with oral squamous cell cancer and compares them to people without this cancer. It may help researchers understand what’s different in oral cancer and what could be useful for diagnosis or treatment planning.
Aurora, ColoradoAges 18–100 - NCT05846620Recruiting
Study of lung immune cells and the gut microbiome
This study looks at how immune cells in the lungs relate to the microbiome (the helpful microbes in the gut) in healthy adults. It may help scientists understand what affects lung health and immune balance.
HvidovreAges 40–75 - NCT05852145RecruitingPhase 1/Phase 2
Testing sweet drinks effect on children’s mouth health
This early-stage study looks at how drinking soft drinks with and without sweeteners affects children’s mouths and teeth. It may help researchers understand which types of sweet drinks contribute to more tooth damage.
Mexico City, CuahutemocAges 12–18 - NCT05873231Recruiting
Gut microbiome study for diarrhea after anti-cancer treatment
This trial looks at how changes in the gut (microbiome) relate to diarrhea that can happen after starting anti-cancer therapy. It may help doctors better predict and manage treatment-related diarrhea.
GrazAges 18 years+ - NCT05878977Recruiting
Testing biomarkers in immunotherapy for advanced melanoma
This trial looks at tissue and scan-related markers (“biomarkers”) to better understand how immunotherapy works in people with advanced melanoma. You may receive standard first-line immunotherapy, and your recent scans and health details will help researchers study why some people respond better than others.
LjubljanaAges 18 years+
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Common questions
- Are there clinical trials for microbiome?
- Yes. Clin2 currently lists 349 recruiting microbiome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a microbiome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a microbiome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.