Clinical trials
Migraine clinical trials
A neurological condition causing recurring, often disabling headaches. We’re tracking 190 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07067112Recruiting
Studying immune cells in migraine blood
This study looks at blood samples from women with and without migraine to understand how certain immune cells (called regulatory T cells) might be involved. The goal is to learn more about what causes migraine, which could lead to better treatments.
Clermont-FerrandAges 18–50 - NCT07072910RecruitingPhase 2
Cabergoline for migraine prevention
This trial tests if a once-weekly medication called cabergoline can reduce how often you get migraine headaches. It is for adults who have between 4 and 14 migraine days per month.
Aarhus NAges 18 years+ - NCT05418218Recruiting
International headache registry for people with headache diagnoses
This study collects information from people who have headaches to better understand different headache types. You may help researchers by keeping headache records and allowing follow-up over time.
Hangzhou, ZhejiangAges 4–99 - NCT07061847RecruitingPhase 2
Lidocaine infusion for severe chronic migraines
This trial tests if a lidocaine infusion into an artery in the head can reduce severe chronic daily headaches. It is for people who have tried multiple treatments without enough relief.
Great Neck, New YorkAges 18–75 - NCT07023926Recruiting
Acupuncture to prevent menstrual migraine
This study tests whether acupuncture can reduce the number of migraine headaches around your period. If you often get migraines with your menstrual cycle, this treatment might help prevent them.
Beijing, Beijing MunicipalityAges 18–45 - NCT06995729RecruitingPhase 1
Testing zavegepant nasal spray in children with migraines
This trial tests whether the medicine zavegepant (given as a nasal spray) is safe and works well for children aged 6 to 11 who have a history of migraines. If your child gets migraines, this study may help find a new treatment option.
Washington D.C., District of ColumbiaAges 6–11 - NCT06959004Recruiting
Does substance P trigger migraine attacks without aura?
This study tests whether a substance called substance P can cause migraine attacks in people who have migraine without aura. Results may help understand new ways to prevent or treat migraine.
Glostrup MunicipalityAges 18–65 - NCT06972056RecruitingPhase 4
Comparing migraine prevention drugs: atogepant, propranolol, topiramate
This study compares three common migraine prevention medications to see which works best. You might be able to join if you have migraines at least 4 days a month and haven't taken these specific drugs before.
Flagstaff, ArizonaAges 18–70 - NCT06943625Recruiting
Green light and brain stimulation for migraine
This trial tests whether combining green light therapy with a gentle brain stimulation technique (transcranial direct current stimulation, or tDCS) can help reduce migraine pain. It may be an option for people with frequent migraines who have not found relief from other treatments.
Rawalpindi, Punjab ProvinceAges 18 years+ - NCT06904287RecruitingPhase 3
Magnesium for migraine treatment in adults
This trial tests if adding magnesium to a standard migraine medication (prochlorperazine) helps treat migraines more effectively. It could be a good option for adults with migraines who haven't taken these drugs recently.
Oak Lawn, IllinoisAges 18 years+ - NCT06623188Recruiting
Ear stimulation for treating episodic migraine
This trial tests if a device that gently stimulates the ear can reduce migraine attacks. It is for adults with regular migraines who have not had success with at least two preventive medications.
MarseilleAges 18–60 - NCT06871852Enrolling by invitation
Video exercises for migraine relief
This study tests if watching and following a video exercise program can help reduce migraine symptoms. If you have migraines and are between 18 and 65, this might be a way to manage your symptoms without extra medication.
Bandırma, BalıkesirAges 18–65 - NCT06848166Recruiting
Artery blockage treatment for chronic migraine
This trial tests a procedure that blocks a blood vessel in the head to see if it reduces chronic migraine pain. It might help people who have not found relief from other treatments.
Bishkek, BishkekAges 21–70 - NCT06834022Enrolling by invitation
Comparing acupuncture and brain stimulation for migraine
This study compares two non-drug treatments—acupuncture and a gentle form of brain stimulation (tDCS)—to see which one helps reduce migraine headaches better. It's for people who have at least 4 migraine days per month and have never tried acupuncture before.
Ljubljana, LjubljanaAges 18–65 - NCT06810505RecruitingPhase 3
Oral atogepant for preventing migraines in teens
This trial tests an oral medication called atogepant to see if it can prevent migraines in teens aged 12–17. It aims to reduce how often migraines happen and track any side effects.
Huntsville, AlabamaAges 12–17 - NCT06808230Recruiting
Cocoa extract for migraine prevention study
This trial tests whether taking cocoa extract daily can help prevent migraine attacks in people with 4-14 migraines per month. You'll use a phone app to track your headaches and take either cocoa extract or a placebo.
Boston, MassachusettsAges 18 years+ - NCT06795867Recruiting
ACT therapy for chronic migraine disability
This study tests whether Acceptance and Commitment Therapy (ACT), a type of talk therapy that helps you accept difficult thoughts and feelings, can reduce disability caused by chronic migraine. You will be placed in one of two groups to compare ACT with your usual care.
Boston, MassachusettsAges 18–65 - NCT06788977Recruiting
Migraine treatment in pregnancy with a nerve stimulation device
This trial tests if a device that gently stimulates a nerve on your forehead can safely treat migraines during pregnancy. You'll use the device at home and track your headaches via text or email.
Darien, ConnecticutAges 18–44 - NCT06785129Recruiting
Endometriosis and migraine study
This study looks at the link between endometriosis and migraine. Researchers want to understand how these conditions affect each other, so they need people with endometriosis, migraine, or both, as well as healthy volunteers without chronic pain.
St Louis, MissouriAges 12–45 - NCT04939922Recruiting
Headache and dizziness registry for people with headache disorders
This study is a registry, meaning it collects information over time about people with headaches (including migraine, tension-type, and some dizziness-related headaches). It may help researchers better understand these conditions and plan future studies.
Hangzhou, ZhejiangAges 4–99 - NCT06735833Recruiting
Testing embolization for chronic migraines
This study tests a procedure called MMA embolization (blocking a small artery in the head) to see if it can reduce migraine attacks in people with chronic, hard-to-treat migraines.
Walnut Creek, CaliforniaAges 18–65 - NCT06716944Enrolling by invitationPhase 1/Phase 2
Self-acupuncture for migraines: a feasibility study
This study tests whether teaching people with migraines to do acupuncture on themselves (self-acupuncture) is practical and helpful. It is for people who have already had a course of acupuncture that worked for them at a specific London hospital.
LondonAges 18 years+ - NCT06277063Recruiting
Nerve-stimulation device for headache in children and young adults
This trial tests if a gentle nerve-stimulating device worn on the neck (called nVNS) can prevent and treat common headaches like migraine, cluster, and tension-type headaches in children and young adults. If you often get headaches and want a drug-free option, this might help.
Guangzhou, GuangdongAges 7–20 - NCT06690060Recruiting
Mind-body program for chronic migraine
This study tests whether a mind-body program, done remotely, can help people with chronic migraines reduce headache impact. It is for adults who have migraines at least 5 days a month and are willing to learn relaxation and stress-management techniques.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for migraine?
- Yes. Clin2 currently lists 190 recruiting migraine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.