Clinical trials
Migraine clinical trials
A neurological condition causing recurring, often disabling headaches. We’re tracking 200 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06229834Recruiting
Chiropractic care for episodic migraine
This study tests whether chiropractic adjustments (spinal manipulation) can help reduce the number of migraine days you have each month. You will be randomly assigned to one of two groups: one group gets chiropractic care plus usual care, the other gets a sham (fake) treatment plus usual care, so researchers can see if the real adjustments work better.
Boston, MassachusettsAges 18–65 - NCT06248671RecruitingPhase 2
Atorvastatin for preventing migraine attacks
This trial tests whether a daily dose of atorvastatin (a common cholesterol medicine) can prevent migraine attacks in people with episodic migraine. You would keep a headache diary and be randomly assigned to take atorvastatin or a placebo for about 3 months.
BergenAges 18–65 - NCT06277063Recruiting
Nerve-stimulation device for headache in children and young adults
This trial tests if a gentle nerve-stimulating device worn on the neck (called nVNS) can prevent and treat common headaches like migraine, cluster, and tension-type headaches in children and young adults. If you often get headaches and want a drug-free option, this might help.
Guangzhou, GuangdongAges 7–20 - NCT06401642RecruitingPhase 4
Zavegepant for acute migraine with CGRP preventives
This study tests how well a new acute migraine medicine, zavegepant, works and is tolerated in people who are already taking a CGRP-targeting preventive medication. It may help you find an effective treatment when you get a migraine attack.
Phoenix, ArizonaAges 18 years+ - NCT06426316Recruiting
Immune cells and migraines study
This study looks at how certain immune cells and inflammatory chemicals relate to migraines. If you have migraines or an autoimmune condition (like lupus, rheumatoid arthritis, or Crohn's disease), you may be able to participate. The goal is to understand what causes migraines.
Clermont-Ferrand, AURAAges 18–50 - NCT06470958Recruiting
Brain scans in women with period-related migraine
This study uses brain scans (MRI) to compare the brain activity of women who have migraine attacks linked to their period with women who don't have migraine. It aims to find brain features that make some women more prone to menstrually-related migraine.
Glostrup MunicipalityAges 18–40 - NCT06473597RecruitingPhase 4
Comparing Nurtec and Maxalt for migraine in the ER
This trial tests two fast-dissolving migraine medicines, Nurtec ODT and Maxalt MLT-ODT, in adults coming to the emergency room with a migraine. The goal is to see which one works better and faster for pain relief.
Brooklyn, New YorkAges 18–65 - NCT06485336RecruitingPhase 2
Atorvastatin for prevention of chronic migraine
This trial tests whether the cholesterol drug atorvastatin can reduce the number of migraine days in people with chronic migraine (15 or more headache days per month, including at least 8 migraine days). If you have frequent migraines and haven't tried statins before, this study may offer a new preventive option.
BergenAges 18–65 - NCT06485726RecruitingPhase 4
Comparing valproate and propranolol for migraine prevention
This study compares two common migraine prevention medications—valproate (a seizure medicine) and propranolol (a blood pressure medicine)—to see which works better for people with migraines who have never tried prevention before. You may benefit if you experience migraines and are looking for a safe first-line preventive option.
Kafr ash ShaykhAges 18–75 - NCT07694063Recruiting
Online yoga for frequent migraines
This trial tests if online Hatha yoga classes can help adults who have frequent migraines (but not daily). If you have migraines 8–14 days a month and are already on stable medication, this study may offer a gentle addition to your treatment.
Seville, SevillaAges 18–65 - NCT05156398RecruitingPhase 3
Rimegepant to prevent migraine attacks in children
This trial studies whether rimegepant can reduce how often migraine attacks happen in children and teens. It also looks at safety and how well the treatment fits day-to-day life and school activities.
Fort Smith, ArkansasAges 6–17 - NCT06503848Recruiting
Migraine attack treatment response biomarkers study
This study looks at how your body responds to migraine attack treatment, by tracking symptoms and blood markers. It may help find better ways to treat migraines in the future.
BarcelonaAges 18–45 - NCT06504537Recruiting
Theragun vs compression therapy for migraine relief
This study compares two handheld massage devices—a percussive therapy device (Theragun) and a compression therapy device—to see which works better for migraine pain. If you have frequent migraines without aura, this could help you find a simple, drug-free treatment option.
Lahore, Punjab ProvinceAges 18–65 - NCT06509503RecruitingPhase 4
Effect of birth control pills on migraine
This study tests how combined oral contraceptive pills affect migraine in women. It will compare people who take these pills with those using non-hormonal methods like an IUD, to see if the pills help or change the migraine pattern.
Kafr ash ShaykhAges 18–55 - NCT06537700Recruiting
Testing Botox for Chronic Migraine: Does Timing Matter?
This study tests how well Botox works for chronic migraine patients, depending on how long they've had the condition. If you have chronic migraines, haven't had Botox recently, and meet a few other conditions, you may be able to join.
AnconaAges 18–70 - NCT06584409Recruiting
Laser Acupuncture vs Standard for Migraine – Blood Test Study
This trial tests whether laser acupuncture can help migraines by checking two substances in your blood (MMP2 and CGRP). You may be able to join if you have migraines and are not pregnant.
Taichung, TaichangAges 18 years+ - NCT06602479RecruitingPhase 2
Study of MEDI0618 for episodic migraine
This trial tests a new medicine, MEDI0618, against a placebo for people with episodic migraine. The goal is to see if MEDI0618 is safe and effective at reducing migraine days.
Birmingham, AlabamaAges 18–70 - NCT06623188Recruiting
Ear stimulation for treating episodic migraine
This trial tests if a device that gently stimulates the ear can reduce migraine attacks. It is for adults with regular migraines who have not had success with at least two preventive medications.
MarseilleAges 18–60 - NCT06628921Recruiting
Eptinezumab for treating a migraine attack right now
This trial tests if eptinezumab can stop a migraine attack that is already happening. It may help people who get migraines often and are already part of the TACHIS study.
RomaAges 18 years+ - NCT06662461Recruiting
Nerve block for stubborn migraines: Stellate vs occipital
This trial tests which nerve block works better for stubborn migraines: one on the stellate ganglion (a cluster of nerves in the neck) or the greater occipital nerve (at the back of the head). They will also check how these blocks affect a chemical linked to migraine pain. If you have chronic migraines that haven't improved with multiple treatments, you may be eligible.
CairoAges 18 years+ - NCT06690060Recruiting
Mind-body program for chronic migraine
This study tests whether a mind-body program, done remotely, can help people with chronic migraines reduce headache impact. It is for adults who have migraines at least 5 days a month and are willing to learn relaxation and stress-management techniques.
Boston, MassachusettsAges 18 years+ - NCT06735768Recruiting
Daily magnetic brain stimulation to prevent migraines
This study tests a type of magnetic brain stimulation (repetitive TMS) given daily at home to prevent migraines. It may be an option if your migraine medications aren't enough or you want a non-drug treatment.
Vienna, State of ViennaAges 18–65 - NCT06735833Recruiting
Testing embolization for chronic migraines
This study tests a procedure called MMA embolization (blocking a small artery in the head) to see if it can reduce migraine attacks in people with chronic, hard-to-treat migraines.
Phoenix, ArizonaAges 18–65 - NCT06785129Recruiting
Endometriosis and migraine study
This study looks at the link between endometriosis and migraine. Researchers want to understand how these conditions affect each other, so they need people with endometriosis, migraine, or both, as well as healthy volunteers without chronic pain.
St Louis, MissouriAges 12–45
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Common questions
- Are there clinical trials for migraine?
- Yes. Clin2 currently lists 200 recruiting migraine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.