Clinical trials
Motor Neuron Disease clinical trials
Below are recruiting motor neuron disease clinical trials, each written for real people, not researchers. We’re tracking 44 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05136222Recruiting
Testing a night breathing machine setting for muscle-nerve disease
This study helps find the best night-time settings for a non-invasive breathing support device (a machine that helps breathing without a tube). It may help people with motor neurone disease start long-term breathing support more comfortably and effectively.
AdelaideAges 18 years+ - NCT03827187Recruiting
Brain signal training to detect awareness
This study checks whether brain activity patterns can show when a person is aware, even if they can’t reliably communicate. If signs of awareness are found (or if you already know you are aware), the study may also train a brain-computer interface to support communication or movement assistance.
DublinAges 10–80 - NCT07533903Recruiting
Brain-Computer Interface for Arm Control in Paralysis
This trial tests a surgically implanted brain-computer interface (BCI) device designed to help people with severe arm paralysis—from conditions like ALS or stroke—regain some ability to control their arms. The device reads signals from your brain and translates them into arm movements, potentially helping you perform daily activities.
MelbourneAges 21 years+ - NCT06885918Recruiting
ALS Research Collaborative study
This study is a research collaborative that collects information from people with ALS or their families. It aims to better understand the disease and find markers that could help develop treatments.
Watertown, MassachusettsAges 18 years+ - NCT04706234Recruiting
Check swallowing and voice function in neurodegenerative diseases
This study looks at how well the throat and voice-related functions work in people with certain long-term brain or nerve conditions. It uses a specific throat exam during FEES to better understand swallowing and laryngopharyngeal (throat-area) function.
Innsbruck, TyrolAges 18 years+ - NCT07187388Recruiting
Electrical stimulation for jaw pain in motor neuron disease
This study tests whether gentle electrical stimulation around the jaw can ease facial pain, improve jaw movement, and help oral health in people with certain motor neuron diseases like ALS or PLS. It may be a good fit if you have jaw pain and meet a few health conditions.
Davie, FloridaAges 18 years+ - NCT06765499Recruiting
Silkworm pupa powder for nutrition and frailty in motor neuron disease
This trial tests whether silkworm pupa powder can improve nutrition and reduce frailty in people with motor neuron disease (like ALS). It looks for volunteers who are frail, have a confirmed diagnosis, and are willing to provide blood, stool, and urine samples.
Hangzhou, ZhejiangAges 18–80 - NCT06318585Recruiting
Building a database for motor neuron disease research
This study collects information from people with ALS or other motor neuron diseases to better understand how these conditions vary. By joining a database, you help researchers find patterns that could improve care.
Milan, MIAges 18 years+ - NCT06450418Recruiting
Digital app for speech and health monitoring
This trial tests a digital app that tracks speech and health changes. It is open to people with certain neurological conditions, their caregivers, and healthy volunteers.
EdinburghAges 16 years+ - NCT06376279Enrolling by invitation
Genetic testing for metabolic diseases
This trial uses genetic testing to find the cause of suspected metabolic diseases, including some cases of epilepsy. It may help you get a clearer diagnosis and guide treatment.
Ages Any age - NCT05966038Recruiting
Study of ALS and related movement nerve conditions
This study collects and stores medical information from people diagnosed with ALS or certain related conditions affecting movement. It may help researchers better understand how these illnesses change over time and improve future treatments.
Loma Linda, CaliforniaAges 18–90 - NCT05744310Recruiting
Long-term ventilation support and quality of life in ALS
This study looks at how long-term breathing support (a ventilation device used over time) affects quality of life for people with ALS and their families. It also asks family members and children about day-to-day well-being during this treatment period.
Bodø, NordlandAges 8 years+ - NCT05354622Recruiting
Genetic testing study for inherited leg stiffness
This study looks at genes (DNA) to understand an inherited condition that causes gradually worsening leg stiffness. It may help researchers learn what causes the condition and potentially guide future care.
Boston, MassachusettsAges 1 month–30 years - NCT05183152Recruiting
Non-invasive brain signal control for assistive devices
This study tests an assistive device that you control using signals from the brain and muscles without surgery. It may help people with movement problems communicate or operate devices using gentle, non-invasive sensing.
Austin, TexasAges 18–80 - NCT04944940Recruiting
Study tests blood, scans, and genes in SBMA and healthy men
This study looks for early “biomarkers” (measurable signs) in the body using blood tests, imaging scans, and sometimes other procedures in men with genetically confirmed spinal and bulbar muscular atrophy (SBMA). The results may help future drug studies by showing better ways to track disease changes over time.
Bethesda, MarylandAges 18–120 - NCT04961450Enrolling by invitation
Study tracking brain illness markers in motor neuron and frontotemporal disease
This study looks for “biomarkers” (measurable signs in blood or other samples) in people with motor neuron disease and frontotemporal dementia spectrum conditions. It also compares those findings with matched caregivers, to understand what might be happening in these diseases.
Beijing, Beijing MunicipalityAges 18–80 - NCT04302870RecruitingPhase 2/Phase 3
Test medicines for motor neurone disease using adaptive trial design
This study tests treatments for motor neurone disease (MND) and assigns people to different treatment arms in an adaptive way. It may help doctors find out which medicine works best and for whom.
Portadown, County ArmaghAges 18 years+ - NCT01900132Recruiting
Electrical muscle testing for neuromuscular disorders
This study uses a quick, painless electrical test to measure muscle health in people with nerve or muscle disorders and in healthy volunteers. It aims to learn how these measurements change over time, which may help diagnose and monitor these conditions better.
Bethesda, MarylandAges 2–110 - NCT00004568Recruiting
Study of inherited neurological conditions
This study is looking at people with inherited (genetic) neurological conditions, as well as their family members, to better understand these diseases. Participants will receive a thorough evaluation, which may help with diagnosis and research.
Bethesda, MarylandAges 2–120 - NCT07818772Recruiting
Using powerful MRI scans to find markers in motor neuron disease
This study uses a very powerful MRI scanner (7T) to take detailed pictures of the brain and spinal cord in people with motor neuron disease. The goal is to find non-invasive markers that could help diagnose and monitor the disease.
GlasgowAges 18 years+ - NCT06976229RecruitingPhase 1
Stem cell therapy for recent spinal cord injury
This phase 1 trial tests a new treatment made from stem cells (XS228) for people who had a spinal cord injury 14 to 60 days ago. Doctors want to see if it's safe and if it might help with recovery.
Guangzhou, GuangdongAges 18–65 - NCT05663008Recruiting
Testing nerve-to-muscle signal changes to diagnose movement diseases
This study measures how nerves communicate with muscles, using recordings and gels. It aims to spot early, personalized signs of conditions like ALS and related diseases, and to improve diagnosis.
Dublin, LeinsterAges 18 years+ - NCT07543367Recruiting
Brain implant to restore arm movement in ALS
This study tests a surgically implanted brain-computer interface (BCI)—a device that reads signals directly from your brain to help control a computer cursor or robotic arm. It's designed for people with ALS whose arms are paralyzed and who haven't responded to standard treatments.
Jacksonville, FloridaAges 22 years+ - NCT07491484Recruiting
Physical function and quality of life in ALS patients
This trial measures how physical function affects daily life and well-being in people with ALS. It aims to understand how movement abilities impact patient-reported outcomes.
Salisbury, MarylandAges 18 years+
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Motor Neuron Disease trials by city
Studies with a site in or near these metro areas.
Motor Neuron Disease trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for motor neuron disease?
- Yes. Clin2 currently lists 44 recruiting motor neuron disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a motor neuron disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a motor neuron disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.