Clinical trials
Motor Neuron Disease, Amyotrophic Lateral Sclerosis clinical trials
Below are recruiting motor neuron disease, amyotrophic lateral sclerosis clinical trials, each written for real people, not researchers. We’re tracking 44 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05136222Recruiting
Testing a night breathing machine setting for muscle-nerve disease
This study helps find the best night-time settings for a non-invasive breathing support device (a machine that helps breathing without a tube). It may help people with motor neurone disease start long-term breathing support more comfortably and effectively.
AdelaideAges 18 years+ - NCT05663008Recruiting
Testing nerve-to-muscle signal changes to diagnose movement diseases
This study measures how nerves communicate with muscles, using recordings and gels. It aims to spot early, personalized signs of conditions like ALS and related diseases, and to improve diagnosis.
Dublin, LeinsterAges 18 years+ - NCT07818772Recruiting
Using powerful MRI scans to find markers in motor neuron disease
This study uses a very powerful MRI scanner (7T) to take detailed pictures of the brain and spinal cord in people with motor neuron disease. The goal is to find non-invasive markers that could help diagnose and monitor the disease.
GlasgowAges 18 years+ - NCT07571486RecruitingPhase 1/Phase 2
Opening the blood-brain barrier for ALS treatment
This trial tests a device that temporarily opens the barrier between the blood and brain to see if it can help slow down ALS. It may allow treatments to reach the brain more effectively.
ParisAges 18–80 - NCT07543367Recruiting
Brain implant to restore arm movement in ALS
This study tests a surgically implanted brain-computer interface (BCI)—a device that reads signals directly from your brain to help control a computer cursor or robotic arm. It's designed for people with ALS whose arms are paralyzed and who haven't responded to standard treatments.
Jacksonville, FloridaAges 22 years+ - NCT07533903Recruiting
Brain-Computer Interface for Arm Control in Paralysis
This trial tests a surgically implanted brain-computer interface (BCI) device designed to help people with severe arm paralysis—from conditions like ALS or stroke—regain some ability to control their arms. The device reads signals from your brain and translates them into arm movements, potentially helping you perform daily activities.
MelbourneAges 21 years+ - NCT06765564Recruiting
Study of stem cell therapy for amyotrophic lateral sclerosis (ALS) progression
This study tests whether a new treatment using special motor neuron cells made from stem cells (iPSCs) can help people with ALS. The cells will be transplanted into the spinal cord to try to slow the disease and improve function.
Shanghai, Shanghai MunicipalityAges 18–60 - NCT07491484Recruiting
Physical function and quality of life in ALS patients
This trial measures how physical function affects daily life and well-being in people with ALS. It aims to understand how movement abilities impact patient-reported outcomes.
Salisbury, MarylandAges 18 years+ - NCT06820008Recruiting
Using smartphones to track physical changes in ALS
This study uses smartphone apps and digital tools to track physical changes in people with ALS. It aims to better understand how the disease affects daily function, which could help improve future care.
Dublin, DublinAges 18 years+ - NCT07334743Recruiting
A study to find biomarkers in ALS using tiny brain particles
This trial collects blood and spinal fluid samples from people being checked for ALS. The goal is to find clues (biomarkers) in tiny particles from nerve cells that could help doctors better understand and diagnose ALS.
ParisAges 18 years+ - NCT07341984Recruiting
Exercise study for people with ALS
This study tests whether a personalized exercise program, done 3 to 5 times a week for 30 minutes each, can help people with ALS maintain strength and function. It aims to see if tailored physical therapy is safe and beneficial.
Sankt GallenAges Any age - NCT06885918Recruiting
ALS Research Collaborative study
This study is a research collaborative that collects information from people with ALS or their families. It aims to better understand the disease and find markers that could help develop treatments.
Watertown, MassachusettsAges 18 years+ - NCT07233148Recruiting
ALS, MND, or PLS registry study
This observational study creates a registry for people with ALS, MND, or PLS. It helps researchers better understand these conditions and find possible treatments.
Park City, UtahAges 18–110 - NCT07204977RecruitingPhase 1
Acamprosate for ALS with C9orf72 gene change
This trial tests a medication called acamprosate to see if it can slow down ALS in people who have a specific genetic change (C9orf72). If you have this gene change and ALS, this study might offer a new treatment option.
Bethesda, MarylandAges 18–99 - NCT07187388Recruiting
Electrical stimulation for jaw pain in motor neuron disease
This study tests whether gentle electrical stimulation around the jaw can ease facial pain, improve jaw movement, and help oral health in people with certain motor neuron diseases like ALS or PLS. It may be a good fit if you have jaw pain and meet a few health conditions.
Davie, FloridaAges 18 years+ - NCT06765499Recruiting
Silkworm pupa powder for nutrition and frailty in motor neuron disease
This trial tests whether silkworm pupa powder can improve nutrition and reduce frailty in people with motor neuron disease (like ALS). It looks for volunteers who are frail, have a confirmed diagnosis, and are willing to provide blood, stool, and urine samples.
Hangzhou, ZhejiangAges 18–80 - NCT06318585Recruiting
Building a database for motor neuron disease research
This study collects information from people with ALS or other motor neuron diseases to better understand how these conditions vary. By joining a database, you help researchers find patterns that could improve care.
Milan, MIAges 18 years+ - NCT06318598Recruiting
ALS and motor neuron disease biomarker study
This study looks for biological markers in people with ALS or other motor neuron diseases to better understand the different types of the disease. It may help find new ways to treat or manage these conditions.
Milan, MIAges 18 years+ - NCT07127172Recruiting
Brain implant study for controlling devices with your mind
This study tests a brain implant that lets you control external devices like a computer or tablet just by thinking. It is for people with paralysis or severe weakness in both arms due to conditions like spinal cord injury, ALS, or stroke.
London, Greater LondonAges 18 years+ - NCT07118319RecruitingPhase 1
Stem cell therapy safety trial for ALS
This trial tests a new treatment made from stem cells (called XS228CN) injected into the spine. It is primarily a safety study, but doctors will also watch for any signs the treatment may slow ALS progression.
Beijing, Beijing MunicipalityAges 18–75 - NCT07067229Recruiting
Brain stimulation and exercise for motor neuron disease
This study tests whether combining non-invasive brain stimulation (a gentle, non-surgical treatment) with exercise can help people with motor neuron disease (MND). It may improve movement and quality of life for those with mild to moderate symptoms.
Bangkok, PathumwanAges 18–80 - NCT06992596Recruiting
Brain implant study for controlling devices with thoughts
This trial tests a brain implant that lets you control external devices using your thoughts. It's for people with limited arm function due to spinal cord injury, stroke, ALS, or similar conditions.
Abu DhabiAges 18 years+ - NCT06147843Recruiting
Study on weight loss in ALS patients from France and Germany
This study looks at why some people with ALS lose weight and what factors are involved. It follows patients in France and Germany to better understand weight changes and help improve care.
LilleAges 18 years+ - NCT05137665Recruiting
Study tracks ALS and health markers over time at home
This study follows people with ALS and healthy volunteers to measure how specific body fluids, symptoms, and at-home tracking change over time. It may help researchers find early signs of disease changes and better ways to measure treatment effects.
Phoenix, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for motor neuron disease, amyotrophic lateral sclerosis?
- Yes. Clin2 currently lists 44 recruiting motor neuron disease, amyotrophic lateral sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a motor neuron disease, amyotrophic lateral sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a motor neuron disease, amyotrophic lateral sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.