Clinical trials
Motor Neuron Disease clinical trials
Below are recruiting motor neuron disease clinical trials, each written for real people, not researchers. We’re tracking 46 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06318598Recruiting
ALS and motor neuron disease biomarker study
This study looks for biological markers in people with ALS or other motor neuron diseases to better understand the different types of the disease. It may help find new ways to treat or manage these conditions.
Milan, MIAges 18 years+ - NCT06584084Recruiting
Testing a new surface EMG device for muscle and nerve conditions
This study tests a new device that measures muscle and nerve signals using non-invasive (surface) electrodes. It aims to see if this device can replace the standard needle EMG test, which is more painful. The trial includes both healthy volunteers and patients with muscle or nerve disorders.
LuganoAges 18 years+ - NCT06820008Recruiting
Using smartphones to track physical changes in ALS
This study uses smartphone apps and digital tools to track physical changes in people with ALS. It aims to better understand how the disease affects daily function, which could help improve future care.
Dublin, DublinAges 18 years+ - NCT06844370Recruiting
Home vs hospital NIV care for MND
This study compares two ways of starting non-invasive ventilation (NIV) — a breathing machine — for people with motor neurone disease (MND). It aims to see if starting NIV at home is as safe and effective as starting it in the hospital.
CambridgeAges 18 years+ - NCT06992596Recruiting
Brain implant study for controlling devices with thoughts
This trial tests a brain implant that lets you control external devices using your thoughts. It's for people with limited arm function due to spinal cord injury, stroke, ALS, or similar conditions.
Abu DhabiAges 18 years+ - NCT07067229Recruiting
Brain stimulation and exercise for motor neuron disease
This study tests whether combining non-invasive brain stimulation (a gentle, non-surgical treatment) with exercise can help people with motor neuron disease (MND). It may improve movement and quality of life for those with mild to moderate symptoms.
Bangkok, PathumwanAges 18–80 - NCT07127172Recruiting
Brain implant study for controlling devices with your mind
This study tests a brain implant that lets you control external devices like a computer or tablet just by thinking. It is for people with paralysis or severe weakness in both arms due to conditions like spinal cord injury, ALS, or stroke.
London, Greater LondonAges 18 years+ - NCT07132879Recruiting
Telehealth in MND research database
This study is building a database of people with motor neurone disease (MND) in the UK to help with future research. You can take part from home using telehealth (remote appointments).
SheffieldAges Any age - NCT07233148Recruiting
ALS, MND, or PLS registry study
This observational study creates a registry for people with ALS, MND, or PLS. It helps researchers better understand these conditions and find possible treatments.
Park City, UtahAges 18–110 - NCT07446114Recruiting
Brain-computer interface trial for ALS (Canada)
This trial tests a brain-computer interface (BCI) device that may help people with ALS or motor neuron disease regain some control over their environment. It involves implanting the device in a blood vessel in the brain.
Toronto, OntarioAges 18 years+ - NCT07491484Recruiting
Physical function and quality of life in ALS patients
This trial measures how physical function affects daily life and well-being in people with ALS. It aims to understand how movement abilities impact patient-reported outcomes.
Salisbury, MarylandAges 18 years+ - NCT07543367Recruiting
Brain implant to restore arm movement in ALS
This study tests a surgically implanted brain-computer interface (BCI)—a device that reads signals directly from your brain to help control a computer cursor or robotic arm. It's designed for people with ALS whose arms are paralyzed and who haven't responded to standard treatments.
Jacksonville, FloridaAges 22 years+ - NCT07284810Enrolling by invitation
Tracking daily function and quality of life with the Cionic Neural Sleeve
This trial asks new users of the Cionic Neural Sleeve to answer questions about how they move and feel in daily life. It helps understand if the device makes a difference in function and quality of life.
San Francisco, CaliforniaAges 22 years+ - NCT07118319RecruitingPhase 1
Stem cell therapy safety trial for ALS
This trial tests a new treatment made from stem cells (called XS228CN) injected into the spine. It is primarily a safety study, but doctors will also watch for any signs the treatment may slow ALS progression.
Beijing, Beijing MunicipalityAges 18–75 - NCT06422208Enrolling by invitationPhase 1
Parkinson's cell transplant trial using your own cells
This trial tests whether transplanting special dopamine-producing cells made from a patient's own skin cells can help treat Parkinson's disease. It is for people who have had Parkinson's for at least 5 years and still respond well to medication.
Boston, MassachusettsAges 55–80 - NCT06432907Recruiting
Brain signal study during movement in epilepsy patients
This study records brain signals from electrodes already placed in your brain for medical reasons. It looks at how your brain controls movement, which could help develop future devices for people with paralysis.
MoscowAges 18–70 - NCT06765564Recruiting
Study of stem cell therapy for amyotrophic lateral sclerosis (ALS) progression
This study tests whether a new treatment using special motor neuron cells made from stem cells (iPSCs) can help people with ALS. The cells will be transplanted into the spinal cord to try to slow the disease and improve function.
Shanghai, Shanghai MunicipalityAges 18–60 - NCT05474235Recruiting
ALS and motor neuron disease studies for patients, family, and controls
This study looks at people with amyotrophic lateral sclerosis (ALS), people who might have ALS, and also people related to someone with ALS. It may help researchers better understand ALS and related “motor neuron” conditions, and it involves participation that may include blood tests.
Jacksonville, FloridaAges 18 years+ - NCT07253493Recruiting
Bone loss and nerve activity study for postmenopausal women
This study looks at how bone loss in the hip might affect nerve signals to muscles. It compares postmenopausal women with weak bones (osteoporosis in the hip) to those with normal bone density.
Bahçelievler, IstanbulAges 18–65 - NCT07321158Recruiting
Electrical stimulation for arm spasticity after first injury
This trial tests whether different pulse durations of electrical stimulation (NMES) can reduce muscle tightness (spasticity) in the arm after a first-time brain or spinal cord injury. It uses special brain-wave tests to measure changes.
Athens, AtticaAges 18 years+ - NCT06687837RecruitingPhase 1
Stem cell therapy for Parkinson's disease
This trial tests whether implanting your own stem cells (made into dopamine-producing brain cells) can improve Parkinson's motor symptoms. You would need to be a candidate for brain surgery and have a stable medication routine.
Boston, MassachusettsAges 45–80 - NCT07579182RecruitingPhase 1
How Exercise and Hormones Affect Pain in Women
This study looks at how exercise affects pain and hormone levels in women. Researchers will ask you about your activity level, do some physical tests, and measure how your body responds to exercise over several visits.
Houston, TexasAges 18–60
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Common questions
- Are there clinical trials for motor neuron disease?
- Yes. Clin2 currently lists 46 recruiting motor neuron disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a motor neuron disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a motor neuron disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.