Clinical trials
Muscle clinical trials
Below are recruiting muscle clinical trials, each written for real people, not researchers. We’re tracking 1,161 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04875052Recruiting
Study vibration after ACL injury and future arthritis risk
This study looks at whether using vibration after an ACL injury helps predict or reduce the risk of developing post-traumatic osteoarthritis (wear-and-tear arthritis) later. It may help researchers learn which patients are more likely to develop arthritis after ACL reconstruction.
Chapel Hill, North CarolinaAges 16–35 - NCT07443826RecruitingPhase 1/Phase 2
Gene therapy for age-related muscle loss and heart health
This trial tests a gene therapy that may help rebuild muscle and improve blood vessel growth in people ages 35 to 75. It's designed for those with stable health conditions and no history of cancer, heart disease, blood clots, or diabetes.
Coxen Hole, Bay IslandsAges 35–75 - NCT07319247Enrolling by invitation
Laser therapy and pelvic floor training for stress incontinence
This trial combines laser therapy with pelvic floor muscle exercises to treat stress urinary incontinence (leaking urine when you cough, sneeze, or exercise). It may help strengthen the muscles and tissues that control urine flow, reducing leakage.
Meram, KonyaAges 18–65 - NCT07638384Recruiting
MRI Muscle Oxygen Study Using Your Arm
This study uses MRI (a large imaging machine) to measure how much oxygen your arm muscles are getting during and after exercise. Researchers want to understand muscle health and oxygen use, which could help treat muscle diseases in the future.
New York, New YorkAges 20–64 - NCT05000515Recruiting
Breathing muscle training to lower blood pressure in postmenopause
This study compares a breathing-based exercise program with regular aerobic exercise to help lower blood pressure and improve blood vessel function in postmenopausal women. It’s mainly for people with mildly elevated resting blood pressure who are not already doing very intense workouts.
Boulder, ColoradoAges 50 years+ - NCT05002556Recruiting
Bladder cancer follow-up registry for adults in France
This trial is a real-world registry that collects information during follow-up for certain early-stage bladder cancer. It may help doctors understand how urinary test results relate to recurrence and guide monitoring over time.
Aix-en-ProvenceAges 18 years+ - NCT05009394Recruiting
Surgery options for long-term pain after limb amputation
This trial studies different surgical approaches to reduce persistent pain in the leftover part of an amputated limb. You may be able to join if your post-amputation pain has lasted more than a year and your pain level stays high despite stable pain treatments and prosthesis use.
Chicago, IllinoisAges 18 years+ - NCT05048862Recruiting
Brain scan and tests for neuromuscular conditions
This study compares people with neuromuscular disorders to healthy people using questionnaires and brain/neurological tests. It may help researchers understand how these conditions affect the brain and nervous system.
TaipeiAges 20 years+ - NCT05051254Recruiting
Breathing muscle testing in children with breathing muscle weakness
This study looks at how hard it is for children to breathe and how their breathing muscles work, using specific breathing-related tests. It may help doctors better understand breathing problems and choose care more effectively.
ParisAges birth–17 years - NCT05174611RecruitingPhase 2
Vitamin D to strengthen the thigh after ACL surgery
This Phase 2 study tests whether taking vitamin D can improve thigh (quadriceps) muscle strength after ACL reconstruction. It targets people with low vitamin D levels that persist after surgery and weaker thigh strength on the injured side.
Hong KongAges 18–40 - NCT05211986RecruitingPhase 1/Phase 2
Test injection safety for knee osteoarthritis muscle weakness
This Phase 1/2 trial studies whether an injection called IMM01-STEM is safe and well-tolerated for people with knee osteoarthritis who also have muscle weakness. It also looks at whether the treatment could help in this group, while carefully monitoring side effects.
Irvine, CaliforniaAges 50–75 - NCT05232136RecruitingPhase 1/Phase 2
Oncolytic virus treatment for early bladder cancer that keeps coming back
This trial tests an “oncolytic virus” treatment given into the bladder to fight high-grade non–muscle-invasive bladder cancer. It may help people whose bladder cancer did not respond to initial bladder prevention treatments, potentially delaying or avoiding major bladder surgery.
Beijing, Beijing MunicipalityAges 18–80 - NCT05253326Recruiting
Relaxing muscle exercises after spine surgery
This trial tests whether a structured “progressive muscle relaxation” routine can reduce pain and help recovery after spine surgery. You may be asked to learn and practice the relaxation steps even if you’ve never done them before.
Istanbul, ÜsküdarAges 18 years+ - NCT05263596Recruiting
Testing ways to diagnose muscle loss in older adults
This study looks for the best ways to detect sarcopenia, which means age-related loss of muscle strength and mass, in older people in a hospital or care setting. It may help doctors spot muscle problems earlier so they can plan better care.
BaselAges 65 years+ - NCT05293366Recruiting
Long COVID study testing supportive care for multiple body systems
This study looks at people who have recovered from COVID-19 but still deal with long-term problems. It aims to better understand (and potentially help with) ongoing issues that can affect hormones, metabolism, mood, muscles, the heart, lungs, and skin.
NaplesAges 18 years+ - NCT05307367Recruiting
Study exercise and body muscle changes in advanced lung cancer
This study looks at why cancer can cause loss of muscle in people with advanced non–small cell lung cancer, and whether exercise can improve or explain those muscle changes. You may be asked to do physical testing and answer questionnaires while receiving standard palliative cancer treatment.
Copenhagen, DKAges 18–100 - NCT05327647RecruitingPhase 2
Bicalutamide with BCG for bladder cancer after BCG treatment
This trial studies whether bicalutamide can improve outcomes for people with non-muscle-invasive bladder cancer who are starting BCG through the bladder. It may help prevent cancer from coming back or progressing after BCG.
London, OntarioAges 18 years+ - NCT05337397Recruiting
Outpatient laser treatment for repeat low-grade bladder tumors
This trial tests an outpatient laser procedure to remove recurring low-grade, non-solid bladder tumors. It may help prevent or control tumor growth with treatment done outside the hospital, if you meet the tumor and health criteria.
AarhusAges 18 years+ - NCT05394506Recruiting
Study of factors that affect muscle laminopathy with LMNA changes
This study looks at what influences the course of a muscle disease caused by an LMNA genetic change (a type of laminopathy). It may help researchers better understand the disease and how it affects muscle and sometimes breathing or heart function.
Bron, Auvergne-Rhône-AlpesAges 2 years+ - NCT05396456Recruiting
Muscle fragment injections for fecal incontinence symptoms
This trial tests whether injecting your own (autologous) muscle fragments into the anal area can reduce fecal incontinence. It’s for adults with frequent symptoms who have already tried standard medicines and procedures.
Winston-Salem, North CarolinaAges 18 years+ - NCT05414292Recruiting
Testing rapamycin effect on exercise muscle function in older adults
This study looks at how rapamycin (a medication that affects a growth signal in the body) changes muscle responses when older adults do resistance exercise. It may help researchers understand whether this treatment could improve or alter muscle function with aging.
DerbyAges 50–90 - NCT05536531Recruiting
NMES therapy to help prevent ICU muscle weakness
This trial tests whether a device that delivers small electrical pulses to muscles can help prevent breathing and muscle weakness in very sick ICU patients. It also looks at changes in blood markers that may relate to muscle weakness and recovery.
Santiago, Santiago MetropolitanAges 18 years+ - NCT05537298Recruiting
Help for muscle recovery after serious ICU illness
This trial looks at how to improve muscle strength and function after a stay in the ICU for sepsis or acute respiratory failure. If you recover from the illness but your muscles become weak, this study may test an approach to help rebuild strength faster.
Birmingham, AlabamaAges 18 years+ - NCT05627440Recruiting
Protein diet program to improve muscle strength in heart failure
This trial tests whether adding dietary protein can help skeletal muscles recover and function better in people living with heart failure. It may help with strength, muscle wasting, and overall ability to do daily activities.
Boston, MassachusettsAges 18–100
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Common questions
- Are there clinical trials for muscle?
- Yes. Clin2 currently lists 1,161 recruiting muscle studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a muscle trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a muscle trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.