Clinical trials
Musculoskeletal Diseases or Conditions clinical trials
Below are recruiting musculoskeletal diseases or conditions clinical trials, each written for real people, not researchers. We’re tracking 4,023 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05318534RecruitingPhase 1
Testing a new medicine for Cold Agglutinin Disease
This Phase 1 study checks whether an investigational medicine is safe and tolerable, and how the body processes it. For people with Cold Agglutinin Disease, it also looks at early blood markers of whether the disease responds.
LeedsAges 18 years+ - NCT05357378Recruiting
Hip replacement study using a reverse hip implant
This trial looks at how safe and well a specific “reverse” hip implant works in people who need their first total hip replacement. It may help by improving pain and hip function, while closely tracking safety during and after surgery.
Miami, FloridaAges 50–75 - NCT05361694Recruiting
Study aims to distinguish stable vs worsening early myeloma
This study looks at two different “precursor” conditions that can happen before multiple myeloma: MGUS and smoldering myeloma (SMM). Researchers want to better tell which cases are more likely to progress, using blood/urine tests and sometimes bone marrow tissue.
Miami, FloridaAges 18 years+ - NCT05359991Recruiting
Exercise study in children and teens with lung or blood conditions
This study tests how safe and effective a structured exercise program is for children and teens. It also compares results between children with sickle cell disease, cystic fibrosis, and healthy peers (and some teens after COVID-19 infection).
Irvine, CaliforniaAges 10–17 - NCT05353569Recruiting
Testing a new way to detect middle ear fluid or infection
This study looks at whether a new light-based check can help detect middle ear problems such as ear infections or fluid behind the eardrum. If it works well, it could help clinicians identify the problem faster and more accurately for children.
Wauwatosa, WisconsinAges 1–6 - NCT05322785Enrolling by invitation
Breathing sample study to improve exhaled biomarker testing
This study works on better ways to collect and analyze substances from your breath. It may help researchers test how well these “breath markers” reflect lung or whole-body inflammation.
Indianapolis, IndianaAges 4–110 - NCT05266222Recruiting
Collecting respiratory virus samples for a research library
This study collects samples from people who have or might have a cold/respiratory virus, then stores them for future research. It may help researchers better understand respiratory germs and develop better treatments.
Bethesda, MarylandAges 3 years+ - NCT05282654Recruiting
Using phone symptom check-ins to prevent problems after discharge
This trial studies a real-time symptom monitoring system (ePROs) that collects your symptoms during care transitions, like when you leave the hospital. The goal is to catch warning signs early so you can avoid adverse events after discharge.
Boston, MassachusettsAges 18 years+ - NCT05259150Enrolling by invitation
Health for Hearts program for Black adults
This study is testing a community health program aimed at improving heart health. It is designed specifically for Black adults and looks at whether the program is helpful for people like you.
Tallahassee, FloridaAges 18 years+ - NCT05260307Recruiting
Improving hearing of multiple voices and speech understanding
This study tests ways to improve how people perceive space in sound and understand speech when many voices are talking at once. It may help adults with normal hearing or hearing loss better follow conversations in noisy, “overlapping voices” situations.
Boston, MassachusettsAges 18–80 - NCT05279742Enrolling by invitationPhase 1/Phase 2
Study drug to boost a hormone system in HFpEF
This early-phase trial tests a treatment that aims to improve the “natriuretic peptide” hormone system in people with HFpEF (heart failure with preserved pumping strength). It may help reduce symptoms and improve heart and fluid pressure behavior, especially in certain related conditions like kidney disease.
Rochester, MinnesotaAges 18 years+ - NCT05260177Recruiting
40 Hz light therapy for mild to moderate Alzheimer’s
This study tests whether a non-invasive 40 Hz light therapy system can help people with early Alzheimer’s. You’ll likely use the device at home and wear a small activity monitor, while doing memory and thinking tests.
RoskildeAges 40 years+ - NCT05282550RecruitingPhase 2
Trazodone trial to improve sleep in early Alzheimer’s
This study tests whether the sleep medicine trazodone can improve thinking and memory in people with early Alzheimer’s-related changes who also have sleep problems. If better sleep helps the brain, it may improve memory test results over time.
Baltimore, MarylandAges 55 years+ - NCT05292794Recruiting
CereGate therapy for freezing of gait in Parkinson’s
This trial tests whether CereGate therapy can reduce “freezing of gait,” a walking problem, in people with Parkinson’s disease who already have deep brain stimulation (DBS). If you meet the device and medication stability requirements, the study may help your walking and movement symptoms measured during testing.
Redwood City, CaliforniaAges 21–80 - NCT05201469RecruitingPhase 2
VIB4920 for lupus kidney inflammation not responding well enough
This Phase 2 study tests VIB4920 to treat active lupus nephritis, a type of kidney disease caused by lupus. It may help reduce kidney inflammation and improve kidney outcomes in people with active disease despite standard care.
La Jolla, CaliforniaAges 18 years+ - NCT05238740Recruiting
Compare fusion results after two spine surgeries with added biologics
This study compares two types of spine surgery (ALIF or XLIF) for one spinal level, and tests how well the bones fuse when a specific bone-forming product is used. It also looks at how patients feel and function after surgery.
BernAges 18–70 - NCT05245136Recruiting
Blood test study for advanced cancer monitoring
This study uses a blood test (liquid biopsy) to look for tumor DNA in patients with advanced cancer. It aims to see if this test can help doctors monitor the cancer and make better treatment decisions.
Augsburg, BavariaAges 18 years+ - NCT05212129Recruiting
Stimulation of the ear nerve to help gut symptoms
This study tests whether stimulating a nerve in the ear (called auricular vagal nerve stimulation) can improve upper gut symptoms in teens who may have hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobile spectrum disorder (HSD). It also checks whether this treatment helps nerves that control the body (autonomic nervous system) and how well the gut moves.
Milwaukee, WisconsinAges 10–18 - NCT05215171Recruiting
Study breathing and blood changes after 9/11 exposure
This study looks at how breathing problems and blood vessel/heart issues may happen after World Trade Center (WTC) dust exposure. It uses blood samples and breathing tests to understand who may be affected and to compare people with and without WTC-related airway reactivity.
New York, New YorkAges 21–90 - NCT05230173Recruiting
Treat to endoscopic remission in inflammatory bowel disease
This study tests whether switching to a different treatment for inflammatory bowel disease (IBD) can achieve healing of the gut lining. It is for people whose symptoms are under control but who still have significant inflammation in their bowel.
Scottsdale, ArizonaAges 18 years+ - NCT05201131Recruiting
Study of Rezūm treatment for enlarged prostate in Canadian patients
This study looks at outcomes from the Rezūm procedure for men with an enlarged prostate (BPH). You may be asked to complete questionnaires and follow the study plan to help researchers understand how well this treatment works and is tolerated.
Toronto, OntarioAges 18 years+ - NCT05239364Recruiting
Ablation for an abnormal heart rhythm after prior AF surgery
This trial tests a procedure to “ablate” (treat) a specific fast heart rhythm in the upper chambers of the heart that happens after previous atrial fibrillation (AF) ablation or heart surgery. It may help by stopping the rhythm and reducing symptoms, while doctors check how well the targeted mapping and ablation work.
Hamburg, Free and Hanseatic City of HamburgAges 18 years+ - NCT04580420RecruitingPhase 2
Study of an oxalate-lowering medicine for PH1 and kidney failure
This Phase 2 study tests a medicine called DCR-PHXC to lower body oxalate levels in people with PH1 who have advanced kidney failure. By lowering oxalate, the treatment may reduce harm from oxalate buildup and help researchers understand safety and effectiveness.
San Francisco, CaliforniaAges Any age - NCT05173714RecruitingPhase 2
Sit Less and Move More program for people with CKD
This Phase 2 study tests a program to help people with chronic kidney disease (CKD) sit less and move more, plus a medication (semaglutide) for those who qualify. It may help improve health and day-to-day activity while monitoring safety closely.
Stanford, CaliforniaAges 20 years+
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Common questions
- Are there clinical trials for musculoskeletal diseases or conditions?
- Yes. Clin2 currently lists 4,023 recruiting musculoskeletal diseases or conditions studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a musculoskeletal diseases or conditions trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a musculoskeletal diseases or conditions trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.