Clinical trials
Musculoskeletal clinical trials
Below are recruiting musculoskeletal clinical trials, each written for real people, not researchers. We’re tracking 216 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05700682Recruiting
MRI-guided artery blockage procedure for long-term joint pain
This study tests whether an MRI scan that looks at blood flow can help target a joint embolization procedure to reduce chronic shoulder, hip, or knee pain. It first uses MRI to find signs of increased blood flow, then may use the findings to guide treatment if you qualify.
Palo Alto, CaliforniaAges 25–80 - NCT05738824Recruiting
Study how inflammatory muscle diseases naturally change over time
This study follows people with suspected or confirmed inflammatory muscle disease (and sometimes healthy adults) to better understand how the condition progresses and what changes over time. It may help researchers identify patterns that could guide future treatments.
Bethesda, MarylandAges 2–120 - NCT05739279Recruiting
Study of muscle loss in people with lipedema
This study looks at whether people with lipedema also have low muscle strength or muscle loss, and what factors might be related. It may help doctors better understand lipedema and identify targets for future care.
IzmirAges 18–85 - NCT05742776Recruiting
Ultrasound and sleep quality check in carpal tunnel
This trial studies whether ultrasound exam findings match how well you sleep if you have carpal tunnel syndrome. It may help doctors better understand which ultrasound results go along with worse sleep and symptoms.
Afyonkarahisar, Afyonkarahi̇sarAges 20–80 - NCT05752396Recruiting
Study of Pain Patterns Over Time in Kids
This study follows kids who have a specific type of chronic pain (headaches, stomach pain, or muscle/joint pain) to better understand how pain changes over time. It also checks whether certain factors are linked to those pain patterns.
Cincinnati, OhioAges 10–19 - NCT05814497Recruiting
Brain scan study of how kids process chronic pain
This study looks at how the brain processes pain sensations in children with certain long-lasting pain conditions. It may help researchers understand what’s happening in the nervous system and guide better treatments.
Cincinnati, OhioAges 10–17 - NCT05895032Recruiting
Exercise program for children with hemophilia A or B
This trial studies whether a structured exercise program helps children with hemophilia A or B safely. It looks at children’s ability to exercise and function, while aiming to avoid complications like leg bleeds or injuries.
Canterbury, KentAges 6–12 - NCT05989230Recruiting
Emotional awareness therapy for pain after orthopedic injury
This trial tests a therapy that helps people understand and express their emotions to manage long-term pain after a serious bone injury. It may help if you have had pain most days for at least three months following surgery for an orthopedic injury.
Baltimore, MarylandAges 18 years+ - NCT06004804Recruiting
Video group therapy for chronic pain in older Veterans
This study tests whether group therapy sessions held over video can help older Veterans manage chronic muscle or joint pain. It focuses on teaching practical skills to reduce pain and improve quality of life.
West Los Angeles, CaliforniaAges 60–95 - NCT06119698Recruiting
Improving Health for Older Adults With Pain Through Engagement
This study tests a program to help older adults with long-lasting bone, joint, or muscle pain become more active. Participants wear a smartwatch and get support to manage their pain and improve their health.
Boston, MassachusettsAges 55 years+ - NCT06157177RecruitingPhase 4
M640 for acute low back pain study
This trial tests a new treatment (M640) for people with acute low back pain, with or without sciatica. It aims to see if M640 can help reduce pain quickly.
Auburn, AlabamaAges 18–80 - NCT06167928Recruiting
Developing new treatments from donated tissue
This study collects tissue from children having surgery for polydactyly or hip dislocation, so researchers can develop new treatments for muscle and bone problems.
Oswestry, ShropshrieAges Any age - NCT06243848Recruiting
Injection vs. surgery for carpal tunnel syndrome
This trial compares two treatments for carpal tunnel syndrome: an ultrasound-guided injection and a surgery to take pressure off the median nerve. It aims to see which one provides better relief for symptoms like numbness and tingling.
AfyonkarahisarAges 18–75 - NCT06297447Recruiting
Keeping it Simple: rehab for chronic pain
This study looks at how to better help people with ongoing muscle or joint pain who are getting rehabilitation through their local municipality. The goal is to learn what works best for you.
Holbæk, Region SjællandAges 18 years+ - NCT06395428RecruitingPhase 4
Haloperidol for severe back pain in the ER
This study tests whether the medication haloperidol, given in the emergency room, can help relieve severe back pain that started on its own (not from an injury). It compares haloperidol to a common pain reliever called ketorolac.
Kalamazoo, MichiganAges 18–65 - NCT06409962Recruiting
New school program for childhood obesity and prediabetes
This study tests a new program to help children with obesity, focusing on those with slightly higher blood sugar (prediabetes). It takes place at a school and requires both parent and child consent.
CórdobaAges 6–16 - NCT06451120RecruitingPhase 2
Platelet-rich plasma injections for knee arthritis
This study tests whether platelet-rich plasma (PRP) injections can help knee arthritis in both younger and older adults. If you have knee pain from arthritis and haven't had other treatments recently, you might be able to join.
San Francisco, CaliforniaAges 18–70 - NCT06451588RecruitingPhase 2
Fecal transplant for axial spondyloarthritis
This trial tests whether a fecal microbiota transplant (a procedure that transfers healthy bacteria from a donor into your gut) can help reduce inflammation and improve symptoms of axial spondyloarthritis. It may be an option if your disease is active despite current treatments.
TromsøAges 18–65 - NCT06455969RecruitingPhase 4
Stress and resilience in healthy active adults
This study looks at how your body handles stress from exercise and other challenges. It is for healthy, active adults who are not taking medications or hormonal birth control.
Pittsburgh, PennsylvaniaAges 18–40 - NCT07691580Recruiting
Study of forces during ERCP
This study measures the physical forces doctors apply during an ERCP procedure. It aims to understand how different techniques affect the procedure's success and safety.
Amiens, PicardieAges 18 years+ - NCT06500780Recruiting
Pain and depression support for African Americans
This study tests a program that helps people with both long-term pain and depression. It includes coaching and support to help you feel better and manage your health. The study is for Black or African American adults.
Indianapolis, IndianaAges 18 years+ - NCT06512727Recruiting
Pain management study for Black older adults with long-term joint pain
This study tests two different approaches to help Black adults aged 50–92 manage chronic muscle or joint pain in their hips, knees, lower back, or ankles. It aims to find which method works better to reduce pain and improve daily life.
Gainesville, FloridaAges 50–92 - NCT06514716Recruiting
Steroid shot vs. standard procedure for knee arthritis
This study tests whether a corticosteroid shot (a strong anti-inflammatory medicine) into the knee joint works better than the standard GAE procedure for people with knee osteoarthritis. It aims to see which approach provides better pain relief and function.
ZagazigAges 18–80 - NCT06516172Recruiting
The Bern Rehabilitation Registry for Chronic Conditions
This trial is creating a registry to study how people with chronic diseases benefit from rehabilitation programs. If you are an adult with a long-term health condition and have been referred to rehab, your data could help improve care for others.
Heiligenschwendi, Canton of BernAges 18 years+
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Common questions
- Are there clinical trials for musculoskeletal?
- Yes. Clin2 currently lists 216 recruiting musculoskeletal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a musculoskeletal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a musculoskeletal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.