Clinical trials
Nephrectomy clinical trials
Below are recruiting nephrectomy clinical trials, each written for real people, not researchers. We’re tracking 54 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03977571Recruiting
Surgery plus cancer drugs for kidney cancer that spread
This trial studies whether removing the kidney tumor with “deferred cytoreductive nephrectomy” (surgery at a later time) works best for people whose metastatic kidney cancer is already present. It compares a standard treatment approach using either immunotherapy (nivolumab/ipilimumab) or a targeted pill plus immunotherapy (TKI/IO), with planned surgery afterward.
Aarhus, Central Region of DenmarkAges 18 years+ - NCT07726550Recruiting
Comparing two nerve blocks for open kidney surgery pain relief
This study compares two different nerve-block techniques to see which works better for pain control after open kidney surgery. One block targets muscles between the ribs, the other targets muscles around the spine. You will be randomly assigned to one of the two groups.
Tekirdağ, TekirdağAges 18–65 - NCT07461090Recruiting
Laparoscopic vs. open kidney removal surgery study
This study compares laparoscopic (keyhole) and open surgery for removing all or part of a kidney. It looks at how well each method works and how much it costs, to help decide which is better for patients with certain kidney conditions or tumors.
Shibīn al Kawm, Shebin ElkomAges 1 year+ - NCT04968990RecruitingPhase 2
New Wilms tumor treated with proton beam abdominal radiation
This trial studies a specific type of radiation (proton beam) given to the abdomen after surgery and/or chemotherapy in children and young people with newly diagnosed Wilms tumor. The goal is to improve cancer control while carefully targeting radiation to the right stage of disease.
Memphis, TennesseeAges Any age - NCT07321197Recruiting
Kidney removal with or without lymph node removal for high risk kidney cancer
This study is for people with high-risk kidney cancer who are having their whole kidney removed. It compares surgery alone versus surgery plus removing lymph nodes from the tumor area to see if removing the nodes helps control the cancer better.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07533669Recruiting
Sensory room visit before kidney transplant surgery
This study tests whether spending time in a calming sensory room before kidney transplant surgery helps reduce pain, anxiety, and sleep problems. You would visit a specially designed room with soothing sights, sounds, and textures before your operation.
SakaryaAges 18 years+ - NCT07234409Recruiting
Robotic partial nephrectomy for small kidney tumors
This trial compares different surgical methods for removing kidney tumors using a single-port robot. It aims to find the best approach for treating stage 1 kidney cancer.
MilanAges 18 years+ - NCT07226544RecruitingPhase 2
Ivonescimab before surgery for high-risk kidney cancer
This trial tests giving the drug ivonescimab before surgery for patients with high-risk clear cell kidney cancer. The goal is to see if it can help shrink the tumor and improve outcomes.
Duarte, CaliforniaAges 18 years+ - NCT07141225Recruiting
Testing no-clamp, no-suture robot kidney surgery
This study is testing a special technique in robot-assisted kidney surgery where the blood supply to the kidney is not clamped and the tumor is removed without sutures. It may reduce damage to healthy kidney tissue and speed recovery.
Nanjing, JiangsuAges 18–80 - NCT07062952Recruiting
Salt substitute to protect kidney after tumor surgery
This study tests whether using a salt substitute instead of regular salt can help protect kidney function after kidney tumor surgery. It is for people who had a kidney removed (either full or partial) and whose remaining kidney is working well.
Nanjing, JiangsuAges 18 years+ - NCT07020169Recruiting
Using AI 3D kidney models to guide partial nephrectomy
This trial tests if a 3D kidney model made with artificial intelligence helps surgeons remove a kidney tumor (partial nephrectomy) more precisely. It may help preserve healthy kidney tissue while treating the cancer.
Nanjing, JiangsuAges 18–80 - NCT06903312RecruitingPhase 4
Removing the main kidney tumor during immunotherapy for advanced kidney cancer
This trial tests whether removing or burning (ablating) the main kidney tumor helps people with advanced kidney cancer who are already doing well on immunotherapy. Researchers want to see if combining local treatment with ongoing immunotherapy can improve outcomes.
RomaAges 18 years+ - NCT06892743Recruiting
Comparing two pain blocks for kidney removal surgery
This trial compares two ultrasound-guided nerve blocks to see which one provides better pain relief for patients undergoing open kidney removal (nephrectomy). If you have kidney cancer and are scheduled for this surgery, you may be able to join.
Maadi, Cairo GovernorateAges 18–70 - NCT06837909Recruiting
Nerve block vs wound injection for breathing after kidney donation
This study compares two ways to manage pain after laparoscopic kidney donation surgery: a nerve block (injection near the belly muscles) versus injecting numbing medicine directly into the surgical wound. The goal is to see which method helps you breathe better after surgery.
Petah TikvaAges 18 years+ - NCT06751498Recruiting
Predicting kidney function after partial nephrectomy with AI
This trial uses a special computer model to predict how well your kidneys will work after surgery to remove part of a kidney (partial nephrectomy). It may help doctors plan better care for people with early-stage kidney tumors.
Nanjing, JiangsuAges 18–80 - NCT06715878Recruiting
Robot-assisted surgery for small kidney tumors without cutting blood supply
This study tests a new, gentle way to remove small kidney tumors using a robot. The goal is to avoid cutting off blood supply to the kidney and to leave healthy tissue behind. It may help you keep more kidney function while still treating the cancer.
ShanghaiAges 15–80 - NCT06595329RecruitingPhase 1
Pain relief after kidney cancer surgery: epidural vs spinal opioids
This trial compares two ways to manage pain after open kidney cancer surgery: an epidural (a thin tube placed near your spine) versus a single spinal injection of opioids. Both aim to control pain, but the study wants to see which method works better, with fewer side effects.
SplitAges 18 years+ - NCT06401330RecruitingPhase 3
Personalized treatment for pediatric Wilms tumor
This study tailors treatment for children with Wilms tumor based on specific tumor features and risk factors. The goal is to give the right amount of therapy to each patient to minimize side effects while maintaining high cure rates.
Birmingham, AlabamaAges Up to 30 years - NCT07672860RecruitingPhase 2
UDCA to protect kidneys during partial nephrectomy
This clinical trial is testing whether a medicine called ursodeoxycholic acid (UDCA) can help protect the kidneys during partial nephrectomy (removing only the tumor while keeping the healthy part of the kidney). It is for people with early-stage kidney tumors who will have temporary interruption of blood flow to the kidney during surgery.
Nanjing, JiangsuAges 18–75 - NCT06147349Recruiting
Kidney cancer observation study
This study follows people with kidney cancer who are scheduled for surgery to remove their tumor. It aims to learn more about the disease and how it behaves over time.
Milan, MIAges 18 years+ - NCT05842044RecruitingPhase 2
NSAID pain medicine after robotic kidney-sparing surgery
This Phase 2 study looks at whether taking an anti-inflammatory pain medicine (an NSAID) after robotic partial nephrectomy is safe and helpful. It may reduce pain while checking for stomach, bleeding, and heart-related side effects after kidney-sparing surgery.
Miami, FloridaAges 18–99 - NCT05810571Recruiting
Pain-control injections compared after open kidney surgery
This study compares two types of pain-control injections placed near the back to see which works better after open kidney (nephrectomy) surgery. If you’re having elective open nephrectomy, it may help doctors choose the safest and most effective way to reduce postoperative pain.
İzmitAges 18–85 - NCT05738694RecruitingPhase 3
Test axitinib plus immunotherapy before kidney cancer surgery
This study tests whether taking axitinib plus an immunotherapy drug (PD-1) before surgery can help people with kidney cancer live longer without the cancer coming back. It’s focused on people who have a higher-risk kidney tumor based on scans and pathology findings.
BeijingAges 18–80 - NCT05319015RecruitingPhase 2
Combination drug therapy before surgery for kidney cancer with vena cava clot
This trial tests two drugs, lenvatinib and pembrolizumab, given before surgery to shrink kidney cancer that has spread into the large vein carrying blood to the heart (the vena cava). The goal is to see if this approach makes surgery more effective and improves outcomes.
Dallas, TexasAges 18 years+
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Common questions
- Are there clinical trials for nephrectomy?
- Yes. Clin2 currently lists 54 recruiting nephrectomy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a nephrectomy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a nephrectomy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.