Clinical trials
OA Knee clinical trials
Below are recruiting oa knee clinical trials, each written for real people, not researchers. We’re tracking 64 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06929871Recruiting
Cementless vs. cementless knee replacement for osteoarthritis
This trial compares two types of knee replacements: one where the implant is glued in (cemented) and one where it locks into the bone without glue (cementless). It is for people with knee osteoarthritis who need a first-time total knee replacement.
LondonAges 18 years+ - NCT05517434RecruitingPhase 2/Phase 3
Autologous bone and fat injections versus saline for knee OA
This trial compares different knee injections made from your own bone marrow and/or fat, plus platelet-rich plasma (a blood-derived healing factor), against saline (placebo) to treat painful knee osteoarthritis. It aims to see whether these “autologous” injections reduce knee pain and improve function.
Toronto, OntarioAges 30 years+ - NCT06187038Recruiting
Pain education study for knee osteoarthritis
This trial tests if learning about chronic pain can help people with knee osteoarthritis feel better. You'll join a program that teaches you about pain and how to manage it.
São PauloAges 40–80 - NCT06930677Recruiting
Knee osteoarthritis treatment study using embolization
This trial tests a new treatment called embolization using a special material (NBGM200) to block certain blood vessels in the knee. It may help reduce pain and improve function in people with knee osteoarthritis.
GhentAges 50 years+ - NCT06893302Recruiting
Bone marrow injection during knee scope for cartilage or meniscus
This trial tests if adding a bone marrow injection to standard knee arthroscopy helps your knee heal better. It is for people with a torn meniscus or damaged cartilage who have healthy knee joints without arthritis.
New York, New YorkAges 18–64 - NCT07329023Recruiting
Acupressure for Knee Arthritis in Older Chinese Adults
This trial tests whether learning self-administered acupressure (a type of massage using fingertips) can help older Chinese adults with knee arthritis manage their pain and stiffness without medication. If you join, you will receive training in a community setting and use a smartphone app to track your progress.
KowloonAges 60 years+ - NCT07354542Recruiting
Relaxation therapy for pain and sleep after joint replacement
This trial tests if different relaxation methods, such as breathing exercises or virtual reality, can help reduce pain and improve sleep after hip or knee replacement surgery. It is designed for people who have had a joint replacement and are able to use a mobile phone or tablet.
Bartın, CenterAges 18 years+ - NCT07482332Recruiting
Core exercises for knee arthritis in women
This study tests if core stability exercises can reduce pain and improve function in women with knee osteoarthritis. It is designed for those who have not had recent physical therapy and can move their knees and hips freely.
SivasAges 45–65 - NCT07478861Enrolling by invitation
Vibration training for seniors with knee arthritis and obesity
This study tests whether whole-body vibration training can help older adults who have both severe knee arthritis and obesity. It aims to improve strength, mobility, and quality of life.
Banī SuwayfAges 60–75 - NCT07161336RecruitingPhase 2
Methotrexate for knee arthritis with swelling seen on ultrasound
This trial tests if methotrexate (a medicine that reduces inflammation) can improve knee pain and swelling in people with knee osteoarthritis. It is for patients who have signs of synovitis (inflammation inside the joint) that can be seen on an ultrasound.
Dhaka, Dhaka DivisionAges 40–70 - NCT06617975Recruiting
Spa therapy for knee arthritis
This trial tests whether spa therapy (balneotherapy) can help people with knee osteoarthritis. You would receive treatment at the Santenay spa as part of your regular care.
Santenay, BurgundyAges 50–80 - NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Birmingham, AlabamaAges 45–80 - NCT07481461Recruiting
Knee alignment and biology in osteoarthritis
This study looks at how changes in knee alignment affect symptoms and joint biology in people with early knee osteoarthritis. It may help doctors understand how to better treat knee OA.
Leuven, Vlaams-BrabantAges 18 years+ - NCT07246109Enrolling by invitation
Knee Brace and Muscle Training for Osteoarthritis
This study tests whether wearing a knee brace and doing muscle training exercises can help people with knee osteoarthritis feel better and move more easily. It may be a good option if you have not had knee surgery and are not already in another treatment program.
TaichungAges 55 years+ - NCT06681142Recruiting
Pharmacist-physiotherapist team care for early knee osteoarthritis
This study tests a new way to manage early knee osteoarthritis by having a pharmacist and physiotherapist work together. You might get help with pain, stiffness, and movement without needing surgery or strong medications.
Sherwood Park, AlbertaAges 50 years+ - NCT06702046Recruiting
Pulsed radiofrequency acupuncture for knee osteoarthritis
This trial tests whether a special type of acupuncture using mild radiofrequency energy can reduce knee pain and improve function in people with knee osteoarthritis. It involves 4 weeks of treatment and a 3-month follow-up to see if the benefits last.
Taipei, StateAges 45–85 - NCT07309003Recruiting
Electrical stimulation and exercise for knee osteoarthritis
This study tests whether a special electrical stimulation (called FES) combined with exercise can help strengthen the muscles around your knee. It may reduce pain and improve function for people with moderate knee osteoarthritis.
Ankara, AnkaraAges 50–65 - NCT07673328Recruiting
Knee brace study for people with knee arthritis
This study tests a motorized knee brace for people with knee osteoarthritis. The brace helps support your knee as you walk, climb stairs, and go up and down ramps.
Ann Arbor, MichiganAges 18–85 - NCT07637682Recruiting
Percutaneous Neurostimulation for Knee Osteoarthritis Pain
This trial tests a minimally invasive nerve-stimulation treatment for moderate to severe knee osteoarthritis pain in adults who have not found relief with standard treatments. The procedure uses small needles to deliver electrical stimulation near nerves to reduce pain.
TantaAges 18 years+ - NCT07219888Enrolling by invitationPhase 4
Comparing suzetrigine and oxycodone for knee replacement pain
This study compares a new pain medicine called suzetrigine with a commonly used opioid, oxycodone, for pain after a knee replacement. The goal is to see which works better and has fewer side effects.
Louisville, KentuckyAges 21–89 - NCT06658249Recruiting
Core exercises vs foot-ankle strength for knee arthritis
This study compares core strengthening exercises with foot-ankle exercises to see which helps more with knee osteoarthritis symptoms like pain and walking difficulty. It might help you move better and climb stairs more easily.
Lahore, Punjab ProvinceAges 40–65 - NCT06911359RecruitingPhase 2
Anti-inflammatory vs. Prolotherapy for Knee Osteoarthritis
This study tests whether anti-inflammatory medications or dextrose prolotherapy (sugar water injections) can reduce knee pain and improve function in people with knee osteoarthritis. If you are a military healthcare beneficiary with moderate to severe knee pain, you may be able to join.
Travis AFB, CaliforniaAges 45–75 - NCT07308873Recruiting
Gait and knee osteoarthritis pain study
This study looks at how walking patterns relate to knee pain from osteoarthritis. It aims to understand individual differences to improve future treatments.
Pittsburgh, PennsylvaniaAges 45–80 - NCT05495334Recruiting
Add knee osteoarthritis outcomes to a patient registry
This study tests a new way to collect how people with knee osteoarthritis feel and function after usual care (like injections, nerve-blocking procedures, or knee replacement). It may help improve future treatment decisions by using your regular follow-up reports in an app or online.
Phoenix, ArizonaAges Any age
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Common questions
- Are there clinical trials for oa knee?
- Yes. Clin2 currently lists 64 recruiting oa knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a oa knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a oa knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.