Clinical trials
Obesity clinical trials
Excess body weight that increases the risk of many other health conditions. We’re tracking 1,500 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05542407RecruitingPhase 1
ONC201 plus atezolizumab for endometrial cancer and obesity
This Phase 1 study tests ONC201 together with atezolizumab in people with metastatic or returning endometrial cancer, especially when obesity may be driving the cancer. It aims to find a safe dose and see whether the combination can slow the cancer’s growth.
Chapel Hill, North CarolinaAges 18 years+ - NCT05545306Recruiting
Study tests how extra calories change your daily energy use
This study looks at how eating more calories affects your body’s natural heat production and total energy use over a full day. It may help researchers better understand how the body manages weight and energy.
Phoenix, ArizonaAges 18–60 - NCT05569785Recruiting
Bariatric surgery and exercise to study muscle changes
This study looks at how exercise and bariatric surgery (gastric bypass or sleeve) affect your muscle strength and health. You may be eligible if you are an adult with obesity who is planning one of these surgeries.
DerbyAges 18–70 - NCT05585190Recruiting
Sit-stand desk study for people at diabetes risk
This trial tests whether using a sit-stand desk at work helps people who are overweight and at risk for diabetes. Participants may be asked to change how much they sit during the workday to improve health markers.
Milwaukee, WisconsinAges 18–79 - NCT05589155Recruiting
Using a phone app to improve blood sugar and weight
This study looks at whether a mobile phone app can help people with type 2 diabetes improve their health habits, including blood sugar monitoring and weight. You may be able to join if you already check your blood sugar daily and are able to use a smartphone.
San Diego, CaliforniaAges 18–64 - NCT05602805Recruiting
Study using a health data bank for weight management
This study builds a data bank to help track how people manage overweight or obesity at the hospital. It may help improve care for future patients by learning what treatments and outcomes work best.
Québec, QuebecAges 18 years+ - NCT05619705Recruiting
Health coaching for pregnant women through home visits
This trial tests a structured health-coaching program delivered during home visits to help pregnant people improve health habits during pregnancy. It may help you with support like tracking weight and following a planned coaching routine.
Baltimore, MarylandAges 18 years+ - NCT05623007Recruiting
Diet and gut bacteria study for vaccinated teens with COVID
This trial tests whether changing diet can shift gut bacteria in overweight or obese teens after COVID-19 vaccination. The goal is to see if dietary changes can affect health markers related to the gut and immune system.
Jakarta Pusat, DKI JakartaAges 12–17 - NCT05632406Recruiting
Breathing training to improve breathing and blood pressure
This study tests whether a breathing device training program can improve breathing and blood pressure. It may help people who have higher blood pressure and may feel out of breath, especially those who have weight-related breathing strain.
Tallahassee, FloridaAges 18–45 - NCT05646901Recruiting
Study how gut bacteria may affect loss of eating control
This study looks at how gut bacteria and the brain may be involved when people struggle to control eating. It may help researchers understand the body’s signals behind eating control problems.
Girona, GironaAges 30–65 - NCT05651724Recruiting
MASH screening study for people with diabetes or obesity
This study screens participants for MASH (a type of liver fat inflammation) using information about your health and risk factors. It may help you and your care team learn whether you could have MASH and need follow-up.
Brussels, Vlaams-brabantAges 18–75 - NCT05653258RecruitingPhase 2/Phase 3
Study cells in fat tissue and aging cells in older adults
This study uses a special lab test on tiny samples from body fat to map different cell types and “senescent” (aging) cells. It may help researchers understand how aging and obesity are linked, which could guide future treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT05656807Recruiting
Weight management program for child care staff and families
This study tests a weight management program delivered through child care centers, involving teachers and parents. It aims to improve healthy habits for children ages 2–5 through changes in the child care setting.
Chapel Hill, North CarolinaAges 2 years+ - NCT05687188Recruiting
Study obesity links to pancreatic cancer in specific groups
This study looks at how weight and related body changes may lead to pancreatic tumors, focusing on people who are African American or Non-Hispanic White. It may help researchers better understand why pancreatic cancer risk differs between groups.
Tampa, FloridaAges 18 years+ - NCT05687604Recruiting
Telehealth program to reduce cancer risk behaviors
This trial offers a scalable telehealth (phone/video) program to help people improve cancer risk habits like low physical activity, higher body weight, and smoking. It may help by giving structured coaching and support in the privacy of your home.
Chicago, IllinoisAges 18 years+ - NCT05706155Recruiting
Switching some animal protein to plant protein for Type 2 diabetes
This study tests whether replacing part of your animal protein with plant-based protein can improve Type 2 diabetes control. It may help your blood sugar and weight management without changing everything about your diet.
Porto Alegre, Rio Grande do SulAges 18–65 - NCT05721976Recruiting
Grandmother–daughter lifestyle program for certain cancer survivors
This pilot study tests a supportive program for grandmothers who finished breast, endometrial, or ovarian cancer treatment and their adult daughters. It aims to encourage healthier habits, including physical activity, using phone-based support and Spanish/English materials.
Miami, FloridaAges 21 years+ - NCT05723679Recruiting
Breathing-targeted program to improve function in HFpEF
This trial studies a breathing-focused treatment to help people with HFpEF (a type of heart failure) feel and function better. It may help improve daily activity by addressing breathing limits that commonly come with this condition.
Dallas, TexasAges 55–90 - NCT05728697Recruiting
Test a liver ultrasound method to measure fat and stiffness
This trial tests a special ultrasound technique during an endoscopy to see how well it can detect changes in the liver from non-alcoholic fatty liver disease. It may help improve non-invasive assessment before or alongside a follow-up liver biopsy.
Boston, MassachusettsAges 18 years+ - NCT05744479RecruitingPhase 4
Metformin to reduce weight gain from antipsychotic medicines
This trial tests whether metformin can help adults with intellectual disability who gained weight from long-term antipsychotic medicines. If you qualify, you may be assigned metformin to improve weight and related health measures.
Toronto, OntarioAges 16–65 - NCT05746039RecruitingPhase 1/Phase 2
Testing semaglutide for advanced lung disease
This study checks whether semaglutide is safe and feasible for people with advanced lung diseases and higher body weight. It may help by testing a structured treatment approach, but it includes several health and safety limits.
Philadelphia, PennsylvaniaAges 18–80 - NCT05748158Recruiting
Study of why weight returns after behavioral weight loss
This study looks at what makes some people regain weight after losing weight in a behavioral weight loss program. You may help researchers understand the role of habits, metabolism, and energy use so better prevention strategies can be developed.
New York, New YorkAges 25–59 - NCT05750732Recruiting
Study weight loss and a gene variant
This trial looks at how weight loss relates to a specific gene difference (CLOCK 3111T/C). You may be eligible if you’re in a certain age and body-mass range and don’t have conditions or medicines that could affect weight or metabolism.
AnkaraAges 20–50 - NCT05774652Recruiting
Teen study following mothers from an earlier pregnancy project
This study follows teenagers whose mothers took part in an earlier lifestyle-in-pregnancy study (started in 2007–2010). It may help researchers understand how that earlier study relates to teen health and development.
OdenseAges 13–65
Hear when a new Obesity trial opens
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Common questions
- Are there clinical trials for obesity?
- Yes. Clin2 currently lists 1,500 recruiting obesity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a obesity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a obesity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.