Clinical trials · California
Oncology clinical trials in California
We’re tracking 136 recruiting oncology studies with a site in California — including Phase 1, Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07306338Recruiting
Integrative oncology program interest survey at USC Norris
This trial asks patients about their interest in an integrative oncology program combining standard cancer care with complementary therapies like nutrition or acupuncture to improve well-being.
Los Angeles, CaliforniaAges 18 years+ - NCT07293247RecruitingPhase 2
Targeted radiation after lung cancer surgery
This trial tests if targeted radiation after surgery can help people with non-small cell lung cancer who still have cancer in their lymph nodes after chemotherapy. Participants will have had surgery and chemotherapy before starting radiation.
Los Angeles, CaliforniaAges 18 years+ - NCT07288112RecruitingPhase 1/Phase 2
Immunotherapy using your own cells for advanced melanoma
This study tests an experimental treatment made from your own immune cells. The cells are collected, trained in the lab to recognize your melanoma, and then injected near your lymph nodes to help your immune system fight the cancer. This is for people whose melanoma has not responded to standard immunotherapy.
Duarte, CaliforniaAges 18 years+ - NCT07279571Recruiting
AI chatbot education for gynecologic cancer patients
This trial uses an AI chatbot to help educate gynecologic oncology patients about HPV vaccination. It aims to see if the chatbot improves knowledge and vaccination rates.
Los Angeles, CaliforniaAges 18 years+ - NCT07283939Recruiting
Testing a tool to adjust chemo doses and reduce treatment delays
This trial tests a computer algorithm called PAGODA that helps doctors adjust chemotherapy doses for people with gastrointestinal cancers. The goal is to prevent unplanned treatment delays while keeping the treatment effective.
Arroyo Grande, CaliforniaAges 18 years+ - NCT07226180Enrolling by invitation
Building models from your tumor to guide treatment
This trial takes a small sample of your tumor to grow a model in the lab. This model helps doctors test which treatments might work best for you.
Irvine, CaliforniaAges 18 years+ - NCT07215624Recruiting
Survey on blood clot prevention after cancer surgery
This study surveys surgeons and surgical advanced practice providers about how they prevent blood clots (deep vein thrombosis) in patients after cancer surgery. It aims to understand current practices and improve future care.
Oakland, CaliforniaAges 18 years+ - NCT07215910RecruitingPhase 3
Testing vorasidenib with temozolomide after radiation for advanced brain cancer
This trial tests whether adding the targeted drug vorasidenib to standard chemotherapy (temozolomide) after radiation helps people with a specific type of advanced brain cancer called IDH-mutant astrocytoma. It is for patients who have not had previous treatments like chemotherapy or radiation and whose tumors have certain genetic features.
Bakersfield, CaliforniaAges 12 years+ - NCT07200830RecruitingPhase 3
Testing different schedules of a targeted radiation drug for advanced prostate cancer
This trial tests two different dosing schedules of a drug called Lutetium-177 PSMA RLT, which delivers radiation directly to prostate cancer cells. It is for men with advanced prostate cancer that has stopped responding to hormone therapy and has spread, who have not yet had chemotherapy for this stage of the disease.
Bakersfield, CaliforniaAges 18 years+ - NCT07166406RecruitingPhase 3
Immunotherapy with or without targeted radiation for advanced liver cancer
This trial tests whether adding a precise, targeted form of radiation (called SBRT) to standard immunotherapy (atezolizumab and bevacizumab) can help people with advanced liver cancer that has spread to the blood vessels or outside the liver. You may be asked to participate in one of two treatment groups to see which approach works better.
San Francisco, CaliforniaAges 18 years+ - NCT07143487Recruiting
Family communication after genetic testing for colon cancer
This trial studies how patients with newly diagnosed colon cancer share genetic test results with their family members. It aims to improve communication and support after learning about hereditary risk.
Arroyo Grande, CaliforniaAges 18 years+ - NCT07097142RecruitingPhase 3
Shorter radiation for bladder cancer with chemo
This trial tests if a shorter course of radiation therapy works as well as the usual longer course for people with bladder cancer who are also receiving standard chemotherapy. The goal is to see if shorter treatment can reduce side effects while still being effective.
Orange, CaliforniaAges 18 years+ - NCT07091617Recruiting
Better genetic testing for young adults with cancer
This study tests a new way to offer genetic testing to young adults (ages 18-39) who have or had cancer. The goal is to make it easier for you to learn if you have inherited gene changes that could affect your cancer and your family's health.
Arroyo Grande, CaliforniaAges 18 years+ - NCT07085091RecruitingPhase 1
Study of ALX2004 for advanced solid tumors
This trial tests a new drug, ALX2004, for people with certain advanced cancers (head and neck, lung, esophagus, or colorectal) that have stopped responding to standard treatments. The goal is to see if the drug is safe and effective.
La Jolla, CaliforniaAges 18 years+ - NCT07059884Recruiting
Exercise program to help people with cancer stay active
This trial tests a distance-based exercise program designed to help people on chemotherapy maintain their physical function and prevent disability. It is for patients with certain cancers who are working full-time and can participate in moderate physical activity.
Dublin, CaliforniaAges 18 years+ - NCT07022678RecruitingPhase 3
Xylitol dental wipes to reduce infection risk in childhood leukemia
This trial tests whether using xylitol dental wipes can lower the risk of bloodstream infections in children with acute myeloid leukemia (AML) who are receiving chemotherapy. If you or your child have AML and will have at least two cycles of chemo that include cytarabine, this study may help reduce infection risk.
Oakland, CaliforniaAges 1–25 - NCT07020117RecruitingPhase 1
Study of AKY-1189 for advanced solid tumors
This trial tests a new radioactive drug, AKY-1189, for people with solid tumors that have spread or cannot be removed. It may help if other treatments have stopped working.
Irvine, CaliforniaAges 18 years+ - NCT07007559RecruitingPhase 2
Evorpacept with trastuzumab and chemo for HER2-positive breast cancer
This study tests an experimental drug called evorpacept when given with trastuzumab and chemotherapy for people with HER2-positive breast cancer that has spread. The goal is to see if this combination can shrink tumors or slow down the cancer.
Orange, CaliforniaAges 18 years+ - NCT07007312RecruitingPhase 3
Ziftomenib plus standard chemo for certain AML patients
This trial tests a new drug, ziftomenib, added to standard chemotherapy for adults with untreated acute myeloid leukemia (AML) who have specific gene changes (NPM1 mutation or KMT2A rearrangement). It aims to see if the combination works better than standard treatment alone.
Clovis, CaliforniaAges 18 years+ - NCT07000084RecruitingPhase 3
Testing gemcitabine with BCG for returning bladder cancer
This trial tests whether adding a chemotherapy drug called gemcitabine to the usual BCG therapy can help prevent bladder cancer from coming back again. If you have had BCG before and your cancer returned, this study might offer a more effective treatment option.
Irvine, CaliforniaAges 18 years+ - NCT06992427RecruitingPhase 3
Gabapentin to prevent opioid use for mouth pain during cancer treatment
This trial tests if taking gabapentin during chemoradiation for head and neck cancer can reduce the need for strong painkillers like opioids. It may help manage mouth pain caused by treatment.
Bakersfield, CaliforniaAges 18 years+ - NCT06958328RecruitingPhase 3
Higher dose radiation for locally advanced pancreatic cancer
This trial tests whether giving a higher dose of radiation to the pancreas is safe and effective for people with locally advanced pancreatic cancer who have already had chemotherapy without progression.
San Francisco, CaliforniaAges 18 years+ - NCT06931340RecruitingPhase 3
Adding chemo to hormone therapy for advanced prostate cancer
This trial is for men with metastatic prostate cancer that has already spread beyond the pelvis. It tests whether adding a chemotherapy drug (docetaxel) to the usual hormone therapy plus apalutamide can help control the cancer better than hormone therapy alone.
Dublin, CaliforniaAges 18 years+ - NCT06917079RecruitingPhase 1
BBO-11818 for KRAS-mutated cancers
This trial tests a new oral drug (BBO-11818) for people with solid tumors that have a specific KRAS mutation. It's for those whose cancer has spread or cannot be removed by surgery and who have not had other cancers recently.
Sacramento, CaliforniaAges 18 years+
Oncology trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting oncology studies listed above.
- UC Irvine Health/Chao Family Comprehensive Cancer Center · 7 studies
- Kaiser Permanente-Oakland · 6 studies
- UC San Diego Moores Cancer Center · 6 studies
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · 6 studies
- Kaiser Permanente Medical Center - Santa Clara · 5 studies
- Kaiser Permanente-San Francisco · 5 studies
- Kaiser Permanente-Walnut Creek · 5 studies
- University of California, Davis · 5 studies
What taking part in a oncology study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Oncology trials in other states
Common questions
- Are there oncology clinical trials in California?
- Yes. We're currently tracking 136 recruiting oncology studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a oncology study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a oncology trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New oncology studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.