Clinical trials
Orthodontics clinical trials
Below are recruiting orthodontics clinical trials, each written for real people, not researchers. We’re tracking 84 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07718061Recruiting
Bacteria in dental plaque with orthodontic retainers
This trial studies the types of bacteria found in dental plaque from people who have orthodontic retainers after braces. It aims to understand how retainers affect oral bacteria.
MurciaAges 18–40 - NCT03906422Recruiting
Study of pain after placing braces archwire
This study compares how much pain people feel after their braces archwire is first put in. It may help orthodontists choose approaches that make the early pain experience easier.
Aurora, ColoradoAges 12 years+ - NCT07513792Recruiting
3D imaging to prevent gum shrinkage during clear aligner treatment
This study tests whether a special 3D imaging tool helps protect your gums from pulling back (receding) while straightening your teeth with clear aligners. Gum recession can expose tooth roots and cause sensitivity, so the trial is exploring whether better visualization during treatment planning prevents this problem.
Liège, LiegeAges 18 years+ - NCT06476574Recruiting
Comparing Retainers: Bonded Wire vs Clear Tray vs Both
This study compares three types of retainers (a bonded wire, a clear plastic tray, and a combination of both) to see which one holds your teeth in place best after braces. It is for adults who have finished non-extraction orthodontic treatment and are generally healthy with good oral hygiene.
CairoAges 18–35 - NCT07183111Recruiting
AI vs. regular instructions for braces patients
This trial compares standard instructions to AI-powered guidance (using a custom ChatGPT) to help patients with braces learn how to care for their teeth. It aims to see which method helps patients follow oral hygiene instructions better.
Islamabad, FederalAges 18–30 - NCT06573996Recruiting
Testing a mouth TENS device for braces pain
This trial tests if a small device placed inside the mouth can ease pain from braces. You'll receive either real or fake treatment with the TENS device to see if it helps with soreness after adjustments.
San Francisco, CaliforniaAges 12 years+ - NCT06948162Recruiting
Dental MRI for routine dental care
This study tests whether a special MRI machine can take detailed images of teeth and jaws for routine dental care. It may help find problems without using X-rays.
Minneapolis, MinnesotaAges 18 years+ - NCT06824493Recruiting
How Braces Affect Mouth Bacteria and Saliva
This study looks at how braces (orthodontic treatment) change the bacteria and proteins in your mouth. Healthy volunteers who have never had dental work or cavities are needed to provide saliva samples before and during treatment.
Xi'an, ShaanxiAges 6–18 - NCT06731465Enrolling by invitation
Clear aligners vs braces for crowded lower front teeth
This study compares clear aligners (removable trays) to traditional braces for treating crowded lower front teeth. It aims to see which method works better and is more comfortable for patients.
Sharjah city, Emirate of SharjahAges 16–45 - NCT07107100Recruiting
Comparing two types of retainers after braces
This study compares two types of retainers (a wire that keeps teeth in place) after braces are removed: one that is directly bonded to the teeth and one that is made indirectly. It looks at which type keeps gums healthy, lasts longer, and how likely it is to break.
Karachi, SindhAges 13–40 - NCT06187337Recruiting
Expanding the upper jaw to fix crowded front teeth in children
This trial tests if expanding the upper jaw can make room for crowded front teeth in children who still have some baby teeth. It aims to help the side front teeth come in properly without needing braces later.
CoppitoAges 6–16 - NCT07091422Recruiting
Testing a new brace glue: does it hold better?
This trial tests a new no-etching glue for braces. Half of your mouth will get the new glue, the other half a standard glue, to see which one holds the brackets better over a year.
Baltimore, MarylandAges 14–35 - NCT07325643Recruiting
Toothpaste and mouthwash to prevent white spots during braces
This study tests if a special toothpaste and mouthwash can stop white spots from forming on teeth while you have braces. It is for people starting orthodontic treatment who have healthy teeth and gums.
BaghdadAges Any age - NCT07747350Recruiting
Laser vs pain pills for braces pain in Malay women
This study compares a low-level laser treatment with standard painkillers to see which works better for reducing pain from getting braces. It is for Malay women aged 18-33 who have never had braces and are generally healthy.
Kota Bharu, KOTA BHARUAges 18–33 - NCT06634017RecruitingPhase 1/Phase 2
Platelet-rich fibrin gel to speed up tooth movement with braces
This study tests whether a special gel made from your own blood (platelet-rich fibrin) can speed up tooth movement after a premolar extraction. You would be wearing braces, and one side of your mouth gets the gel while the other side is the control, so we can see if it works.
Karachi, SindhAges 18–45 - NCT06502886Recruiting
Stability after braces with premolar removal and special retainers
This study tests whether using a special type of retainer (bonded on the tongue side and the roof of the mouth) helps keep teeth stable after braces for people who had their upper and lower first premolars removed. If you're finishing orthodontic treatment and need a retainer, this study may apply to you.
CairoAges 18 years+ - NCT07661277Enrolling by invitation
Success rate of cheekbone mini-screws for braces
This study tests how well tiny screws placed in your upper cheek area work to support braces and move teeth into the right position. It is for adults aged 19 to 35 who need fixed braces on their upper teeth and have not had braces before.
DhakaAges 19–35 - NCT07280455Recruiting
Comparing gold vs. steel retainers after braces
This study compares two types of fixed retainers (gold vs. stainless steel) to see which works better after braces are removed. It's for people aged 15–30 who have completed orthodontic treatment and have a well-aligned lower front teeth.
Baghdad, Baghdad GovernorateAges 15–30 - NCT07239024Enrolling by invitationPhase 1
Comparing two ways to speed up canine tooth movement
This study compares two methods to speed up moving your canine teeth into their correct position after removing the premolars: a small surgical procedure (piezocision) or a natural blood concentrate treatment (injectable platelet-rich fibrin). The goal is to see which method works better for faster, safer tooth movement.
CairoAges 14–22 - NCT05038865Recruiting
How jaw alignment affects teens’ quality of life
This study compares how different types of bite/jaw alignment affect adolescents’ daily comfort and oral-health-related quality of life. It’s mainly done by asking teens to complete questionnaires and comparing groups with and without malocclusion.
Malmö, Skåne CountyAges 12–19 - NCT06068270Recruiting
MOPs cleaning aid for gum disease patients getting braces
This trial tests whether a special type of oral hygiene device (called MOPs) helps protect teeth and gums during orthodontic treatment (braces or aligners) in people with severe gum disease (stage IV periodontitis). It may help prevent further damage and improve the success of moving teeth.
Madrid, MadridAges 18–80 - NCT06944860Recruiting
3D-printed vs. traditional twin block braces for kids
This trial compares a new 3D-printed twin block brace to a traditional one for children with a large overbite (overjet ≥7 mm). It checks how well germs stick, how smooth the brace is, and how well it works—plus how children feel about it.
Kuala Lumpur, Kuala LumpurAges 10–14 - NCT07217756Recruiting
How weight affects braces treatment in teens
This study looks at how having a higher BMI (body mass index) affects treatment with braces during the teenage years. It will compare results between teens with normal weight and those who are overweight to see if there are any differences in how long or how well braces work.
Rochester, New YorkAges 12–18 - NCT07244991Recruiting
Effect of a special toothpaste on plaque bacteria and cavities during braces treatment
This trial tests whether a special paste (MI Paste Plus) can reduce cavity-causing bacteria and prevent early white spots on teeth while you are wearing braces.
Tirana, AlbaniaAges 5–45
Hear when a new Orthodontics trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for orthodontics?
- Yes. Clin2 currently lists 84 recruiting orthodontics studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a orthodontics trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a orthodontics trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.