Clinical trials
Osteoarthritis Knee Pain clinical trials
Below are recruiting osteoarthritis knee pain clinical trials, each written for real people, not researchers. We’re tracking 271 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07248072Recruiting
Nerve blocks for better recovery after knee replacement
This trial tests two types of nerve blocks—iPACK and BiFeS—to see if they help people feel better and recover faster after total knee replacement surgery. It compares adding these blocks to the usual spinal anesthesia.
ErzurumAges 18–75 - NCT07267793Recruiting
Long-term study of CartiPRO for knee pain
This trial tests a treatment called CartiPRO for knee pain caused by osteoarthritis or cartilage damage. It looks at how well the treatment works over a long period and is for people who have a certain type of knee pain that hasn't improved with other treatments.
Seongnam-si, Bundang-guAges 19 years+ - NCT07308873Recruiting
Gait and knee osteoarthritis pain study
This study looks at how walking patterns relate to knee pain from osteoarthritis. It aims to understand individual differences to improve future treatments.
Pittsburgh, PennsylvaniaAges 45–80 - NCT07678996Recruiting
Ozone injections for knee arthritis: finding the right dose
This study tests whether injecting ozone gas into the knee joint can reduce pain in people with knee osteoarthritis. It aims to find the best dose to help with pain during activities like walking.
KayseriAges 40–75 - NCT07367126Recruiting
Nerve pain in knee osteoarthritis: Pain and function study
This study looks at nerve-related pain in people with knee osteoarthritis and how it affects their pain level and daily function. It may help understand if nerve pain is a key factor in your knee OA symptoms.
IstanbulAges 40–70 - NCT07370480Recruiting
Knee Osteoarthritis and Thermal Spa Treatment Study
This trial tests whether a special spa treatment (thermal water therapy) can help with knee osteoarthritis pain and function. If you have moderate to severe knee OA and live near Enghien-les-Bains, France, this study may be a good fit.
Enghien-les-BainsAges 50–80 - NCT07381621Recruiting
Comparing sugar water vs. numbing shots for knee arthritis
This study compares two different types of knee injections for people with knee osteoarthritis. One injection uses a simple sugar solution (dextrose), and the other uses a standard numbing medication (local anesthetic). The goal is to see which works better for reducing pain and improving knee function.
Ankara, AltindagAges 40–65 - NCT07396233Recruiting
Knee Osteoarthritis Therapy: Diagonal Movement Patterns
This trial tests a type of physical therapy called proprioceptive neuromuscular facilitation for people with knee osteoarthritis. It may help reduce pain and improve how well your knee works.
Karachi, SindhAges 40–60 - NCT07434011Recruiting
Smartphone exercise program for knee osteoarthritis
This study tests if an artificial intelligence-powered smartphone app can help people with knee osteoarthritis do exercises at home that reduce pain and improve function.
Madrid, MadridAges 45 years+ - NCT07464080Recruiting
Brain imaging study for knee replacement patients
This study uses advanced brain scans to understand how pain and recovery change after knee replacement surgery. It may help researchers develop better ways to manage pain after surgery.
Ottawa, OntarioAges 18 years+ - NCT07465484Recruiting
Total knee replacement for bow-leg deformity
This study looks at how well total knee replacement works for people who have severe knee arthritis and a bow-leg (varus) deformity. It may help you if you have a lot of knee pain and are considering surgery.
MoscowAges 18 years+ - NCT07472088Recruiting
Knee pain study using weight-bearing CT scans
This trial uses a special CT scan taken while you stand to see how the shape of your knee joint relates to your knee pain. It may help researchers better understand knee arthritis and front-of-knee pain.
Kansas City, KansasAges 18 years+ - NCT07481630RecruitingPhase 3
Testing a new medicine for weight loss and knee pain
This study tests if a new medicine called NNC0487-0111 can help people with extra weight and knee osteoarthritis lose weight and reduce knee pain. If you have knee pain most days and are willing to stop pain relievers for short periods, you may be able to join.
Phoenix, ArizonaAges 18 years+ - NCT07673328Recruiting
Knee brace study for people with knee arthritis
This study tests a motorized knee brace for people with knee osteoarthritis. The brace helps support your knee as you walk, climb stairs, and go up and down ramps.
Ann Arbor, MichiganAges 18–85 - NCT07507175Recruiting
Calf muscle release for women with knee arthritis
This trial tests whether releasing tight calf muscles can help women with knee osteoarthritis feel less pain. It focuses on women who have moderate knee arthritis and a tight spot in their calf muscle.
Giza, Giza GovernorateAges 45–55 - NCT07509307RecruitingPhase 3
Study of a new medicine for weight loss and knee pain in osteoarthritis
This trial tests if a new medicine, NNC0487-0111, can help people with excess weight and knee osteoarthritis lose weight and reduce knee pain. It is for people who have had knee pain for at least three months and who can stop taking pain relievers for short periods before study visits.
Escondido, CaliforniaAges 18 years+ - NCT07513415Recruiting
Injectable knee filler for osteoarthritis pain relief
This trial tests a new injectable filler called ALLOHEAL, injected directly into the knee joint to reduce pain and improve function in people with knee osteoarthritis. The filler is designed to cushion the knee joint and may help reduce pain and stiffness.
Uijeongbu-siAges 40–80 - NCT07547735RecruitingPhase 2
Stem Cell Treatment for Knee Osteoarthritis
This study tests whether special stem cells (called UC-MSCs, derived from umbilical cord tissue) can reduce pain and improve function in people with moderate knee osteoarthritis. Researchers will inject these cells into your knee to see if they help repair damaged cartilage and reduce inflammation.
WuhanAges 40–70 - NCT07598474Recruiting
Pregabalin and Movement Therapy for Knee Osteoarthritis Pain
This trial tests whether a nerve pain medication called pregabalin, applied through ultrasound waves to your knee, combined with gentle movement exercises, can reduce pain in advanced knee osteoarthritis. You'll attend 16 treatment sessions over 4 weeks to see if this combination helps.
Faisalābad, Punjab ProvinceAges 40–60 - NCT07625150Recruiting
PET/MRI Imaging Study of Kneecap Joint Osteoarthritis
This research study uses advanced imaging (PET and MRI scans) to better understand osteoarthritis in the front of the knee, where the kneecap meets the thighbone. You'll help researchers learn how to detect and track this condition earlier.
San Francisco, CaliforniaAges 18 years+ - NCT07630337Recruiting
Cryotherapy to reduce pain medication after knee replacement
This study tests whether applying cold therapy (cryotherapy) after knee replacement surgery helps patients need fewer opioid pain medications than standard care alone. If cryotherapy works, it could help you manage pain more safely after surgery.
Buenos Aires, Buenos AiresAges 18 years+ - NCT07653841Recruiting
Balance vs. strength training for knee osteoarthritis
This study compares two types of exercise programs (a balance-focused training and a progressive strengthening program) added to usual physical therapy. The goal is to see which works better for reducing knee pain and improving daily function in people with knee osteoarthritis.
Islamabad, ICTAges 40–70 - NCT07652372Enrolling by invitationPhase 1
Injectable RAB001 for knee osteoarthritis (Phase 1b)
This trial tests an injectable medication called RAB001 for people with knee osteoarthritis that hasn't improved with other treatments. The goal is to see if it's safe and helps reduce pain.
Beijin, BeijinAges 40–75 - NCT07504562Enrolling by invitationPhase 2
Ejiao Paste for Knee Osteoarthritis Pain
This trial tests a traditional Chinese medicine patch called Knee Pain Ejiao Paste for knee osteoarthritis pain. It aims to see if the paste reduces pain and improves function compared to a placebo.
Shanghai, Shanghai MunicipalityAges 40–75
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Common questions
- Are there clinical trials for osteoarthritis knee pain?
- Yes. Clin2 currently lists 271 recruiting osteoarthritis knee pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis knee pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis knee pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.