Clinical trials
Osteoarthritis Knee Pain clinical trials
Below are recruiting osteoarthritis knee pain clinical trials, each written for real people, not researchers. We’re tracking 271 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07351981Enrolling by invitation
Cooled radiofrequency for knee osteoarthritis pain
This study tests a new approach called cooled radiofrequency (TcPRF) to calm knee pain from osteoarthritis. It may be an option if standard treatments haven't worked and you haven't had certain other treatments recently.
AthensAges 45 years+ - NCT07318116Enrolling by invitation
Cabbage Leaf for Knee Osteoarthritis Pain
This study tests whether applying cabbage leaves to the knee can reduce pain in people with knee osteoarthritis. If you have had knee pain for at least 6 months and are not allergic to cabbage, you may be able to join.
Şirnak, MerkezAges 18–80 - NCT06946329Enrolling by invitation
Water exercise for knee pain in obese men
This study tests whether a supervised water exercise program (called WATERinMOTION) can reduce knee pain and improve movement in obese men with knee osteoarthritis. It may help if you are looking for a gentle, joint-friendly way to manage your knee pain.
Zahedan, Sistan and BaluchestanAges 45–65 - NCT06893250Enrolling by invitationPhase 2/Phase 3
Orthobiologic treatment for knee osteoarthritis
This study tests a treatment made from your own body's healing components to reduce knee pain. It may help people with mild to moderate knee osteoarthritis who haven't had knee surgery or strong pain relievers lately.
Tromsø, TromsøAges 40–70 - NCT06779071Enrolling by invitationPhase 3
NPNP-001 injection for knee osteoarthritis pain
This study tests a new medicine called NPNP-001 for people with knee osteoarthritis who have not gotten enough relief from other treatments. The medicine is given as an injection into the knee to see if it can reduce pain and improve function.
SeoulAges 40 years+ - NCT06444945Enrolling by invitation
Comparing two hands-on therapies for knee osteoarthritis
This study compares two hands-on therapy techniques (Mulligan and Kaltenborn mobilizations) to see which works better for reducing pain and improving movement in people with knee osteoarthritis. If you have mild to moderate knee pain and are between 40 and 70, this trial may help you find a gentler treatment option.
IslamabadAges 40–70 - NCT06444932Enrolling by invitation
Strength training plus joint mobilization for knee osteoarthritis
This study looks at whether adding resistance (strength) exercises to joint mobilization helps people with knee osteoarthritis move better, feel less pain, and get stronger. You'll do standard joint mobilization plus a program of exercises like leg presses and squats.
IslamabadAges 40–70 - NCT06430918Enrolling by invitation
Nerve pain and sleep quality in knee osteoarthritis
This study looks at how nerve pain and sleep quality are related in people with knee osteoarthritis. It aims to help doctors better understand and treat pain.
IzmirAges 18–80 - NCT06211387Enrolling by invitation
Stretching plus resistance exercise for knee osteoarthritis
This study tests whether adding a gentle stretching technique to resistance exercises helps reduce knee pain and improve movement in people with knee osteoarthritis. It may be a good option if you have mild-to-moderate knee arthritis and want to strengthen your knees without surgery.
Islamabad, FederalAges 40–65 - NCT06038240Recruiting
Pain self-management program for knee replacement
This study is testing a program to help people manage pain on their own before and after total knee replacement surgery. It aims to improve recovery and reduce reliance on pain medications.
Charlottesville, VirginiaAges 18–85 - NCT07542808RecruitingPhase 2/Phase 3
Stem cell treatment vs. hyaluronic acid for knee arthritis
This study tests whether an injection of stem cells (special cells that can help repair tissue) works better than a standard hyaluronic acid injection for knee osteoarthritis pain. Both treatments are injected into the knee to reduce pain and improve function.
Abu DhabiAges 18 years+ - NCT03877653Recruiting
Freedom-1 treatment for long-term knee pain in adults
This study tests a procedure called Freedom-1 to reduce long-term, limiting knee pain from knee arthritis. It may help if other non-surgical options didn’t work and you meet specific knee and health requirements.
Placentia, CaliforniaAges 18 years+ - NCT05120492Recruiting
Program for severe knee arthritis and extreme weight
This feasibility study tests a practical approach to help people with very severe knee arthritis and very high body weight. It aims to find an effective and safe way to manage both conditions together in real-world care.
Halifax, Nova ScotiaAges 18–65 - NCT05423587Recruiting
Knee artery procedure for long-lasting knee arthritis pain
This study looks at whether blocking small blood vessels in the knee (genicular artery embolisation) can reduce pain from knee osteoarthritis when other non-surgical treatments haven't helped. It also checks safety and whether people can tolerate the imaging tests needed for the procedure.
ReadingAges 45 years+ - NCT05488093Recruiting
Testing knee movement in severe knee arthritis before replacement surgery
This study checks how well your knee moves and how that relates to pain and function in people with severe knee arthritis who are about to get total knee replacement. It may help doctors better plan and evaluate treatment before surgery.
MontpellierAges 60 years+ - NCT05933434RecruitingPhase 1/Phase 2
Stem cell injection trial for chronic knee osteoarthritis
This early-phase study tests an injection of donor stem cells placed into the knee joint to help reduce symptoms of knee osteoarthritis. You may be eligible if you have long-lasting knee pain from mild-to-moderate arthritis and meet safety and imaging requirements.
Aarhus NAges 40–75 - NCT06054633Recruiting
L-arginine for knee osteoarthritis pain
This study tests whether L-arginine, a natural amino acid, can help with knee pain from osteoarthritis. You might be eligible if you are 40–80 years old, have moderate osteoarthritis on X-ray, and have had knee pain for at least 3 months.
Changsha, HunanAges 40–80 - NCT06187038Recruiting
Pain education study for knee osteoarthritis
This trial tests if learning about chronic pain can help people with knee osteoarthritis feel better. You'll join a program that teaches you about pain and how to manage it.
São PauloAges 40–80 - NCT06658327Recruiting
Stretching for knee arthritis in postmenopausal women
This study compares two types of stretching to see which better reduces pain and improves movement in postmenopausal women with knee osteoarthritis. It may help you find a simple, drug-free way to manage your symptoms.
Lahore, Punjab ProvinceAges 50–65 - NCT06684587Recruiting
Telehealth exercise and mindfulness for knee osteoarthritis pain
This study tests whether a telehealth program combining exercise and mindfulness can help reduce knee pain from osteoarthritis. It is designed for people who have had knee pain for at least 3 months and can attend sessions remotely.
Boston, MassachusettsAges 50 years+ - NCT06773676Recruiting
Home laser device study for knee osteoarthritis relief
This study tests whether using a laser device at home can help reduce knee pain and improve function in people with knee osteoarthritis. You would use the device yourself over several weeks to see if it eases your symptoms.
Ashkelon, Southern DistrictAges 50–90 - NCT07219771RecruitingPhase 3
Testing MOTYS injection for knee osteoarthritis pain
This trial tests an injection called PTP-001 (MOTYS) for people with mild to moderate knee osteoarthritis. It aims to see if the injection can reduce knee pain and improve function.
Birmingham, AlabamaAges 40–80 - NCT02915120Recruiting
Ultrasound-guided nerve treatment for knee osteoarthritis pain
This trial studies whether a targeted, ultrasound-guided “pulsed” radiofrequency treatment can reduce long-lasting knee pain from osteoarthritis. It may help if your knee pain is not improving with common medicines and injections.
Palma, Balear IslandsAges 40 years+ - NCT07580716RecruitingPhase 2
Knee Injection Treatment for Moderate Osteoarthritis
This study tests a new cell-based injection (Allocetra) directly into the knee joint for people with moderate osteoarthritis who haven't benefited from other treatments. The goal is to reduce pain and improve knee function.
Longwood, FloridaAges 64 years+
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Common questions
- Are there clinical trials for osteoarthritis knee pain?
- Yes. Clin2 currently lists 271 recruiting osteoarthritis knee pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis knee pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis knee pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.