Clinical trials
Pain After Surgery clinical trials
Below are recruiting pain after surgery clinical trials, each written for real people, not researchers. We’re tracking 419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07502612Recruiting
Spinal cord stimulation medication tapering study
This study tests whether lowering pain medication can improve how well spinal cord stimulation works. It is for people who already take certain pain medicines and are scheduled to try a spinal cord stimulator.
WilrijkAges 18 years+ - NCT07540689Recruiting
Pain Relief Method for Children's Minimally Invasive Belly Surgery
This study tests a new pain-relief technique called M-TAPA for children ages 1–7 having small-incision belly surgery. Researchers want to see if this method helps reduce pain better than standard approaches after surgery.
Cairo, ElmanialAges 1–7 - NCT07588230Recruiting
Nerve Block for Minimally Invasive Heart Valve Surgery Pain
This study tests a targeted nerve block (pain-numbing injection) to help manage pain after minimally invasive heart valve surgery. Researchers want to see if this technique reduces pain and the need for opioid medications during recovery.
Diyarbakır, Outside of the USAges 18–75 - NCT07575230Enrolling by invitationPhase 4
Pain relief after skin cancer surgery: new drug vs standard
This study compares a new pain medication (suzetrigine) to a common pain reliever (Norco) for people recovering from Mohs micrographic surgery, a specialized procedure to remove skin cancer. The goal is to see if the new medication works better and is safer for post-surgery pain.
Dallas, TexasAges 18–89 - NCT06562634Enrolling by invitation
Ultrasound-guided nerve block for knee surgery pain relief
This study tests a nerve block (erector spinae plane block) to see if it reduces pain after open knee surgery. It aims to find a better way to manage pain with fewer side effects.
CairoAges 18–65 - NCT06139666Enrolling by invitationPhase 4
Liposomal bupivacaine nerve block for rotator cuff surgery
This study tests whether a long-lasting numbing medicine called liposomal bupivacaine (Exparel) works better than standard pain relief for people having rotator cuff surgery. It aims to lessen pain after surgery so you may need fewer pain pills.
Camden, New JerseyAges 18 years+ - NCT05010148RecruitingPhase 3
IV lidocaine after spinal fusion to reduce delirium and pain
This trial tests whether giving lidocaine through a vein after elective spinal fusion surgery can help prevent confusion (delirium) and reduce pain. It may help people recover more comfortably and think more clearly after surgery.
San Francisco, CaliforniaAges 60 years+ - NCT06709391Recruiting
Spinal fusion vs. no surgery for chronic low back pain
This trial tests whether a spinal fusion surgery is better than staying with non-surgical treatments for people with long-term, severe low back pain from worn-out discs in the lower spine. It aims to find out which approach offers better pain relief and quality of life.
GothenburgAges 25–65 - NCT06731998Recruiting
Improving pain control after cancer surgery
This study compares different methods of managing pain after minimally invasive surgery for abdominal cancers. It aims to find which approach works best to reduce pain and improve recovery.
Pittsburgh, PennsylvaniaAges 18–89 - NCT07693270Recruiting
Study looking for markers of pain and opioid response after injury or surgery
This study is looking for biological markers (like blood tests) that can predict how people will respond to pain and opioids after a traumatic injury or surgery. The goal is to help doctors tailor pain treatment to each person.
La Jolla, CaliforniaAges 18 years+ - NCT06817239Recruiting
Low-dose esketamine for preventing confusion after surgery in older adults
This study tests whether a low dose of the medicine esketamine can help prevent confusion after surgery in older adults at higher risk. You may qualify if you are 65 or older, planning a major non-cardiac surgery, and have certain health conditions like high blood pressure or diabetes.
Fuzhou, FujianAges 65–90 - NCT06288256Recruiting
Spine surgery study: genes, thinking, and pain
This study is for people getting planned spine surgery. It looks at how your genes and thinking skills might affect your pain and use of pain medicine after surgery.
New York, New YorkAges 18 years+ - NCT07365800Enrolling by invitationPhase 4
Combination pain control after complex spine surgery
This study tests a combination of three medications (methadone, dexmedetomidine, and ketamine) to control pain after major spine surgery. If you are having complex spine surgery, this trial may offer better pain relief without needing as much opioid medication.
Columbia, MissouriAges 18–79 - NCT06613178RecruitingPhase 4
IV acetaminophen for heart surgery recovery
This trial tests if giving acetaminophen (Tylenol) through a vein after heart surgery can help patients recover better. You may be a good fit if you are having planned heart surgery that is not an emergency.
Vancouver, British ColumbiaAges 18 years+ - NCT07213375RecruitingPhase 2/Phase 3
High-dose steroid to reduce pain after lung surgery
This trial tests if a high dose of dexamethasone (a steroid) can lower pain after keyhole lung surgery. If you are having planned keyhole lung surgery for a lobe or segment, you may be eligible.
Copenhagen, CopenhagenAges 18 years+ - NCT05421273Recruiting
Testing two spinal stimulation patterns for long-term back pain
This study compares two ways of delivering spinal cord stimulation to see which better reduces pain in people with persistent spinal pain syndrome type 2. You would be assigned to one of the stimulation “burst” patterns and followed for changes in your pain experience.
Arnhem, GelderlandAges 18–70 - NCT06525740RecruitingPhase 4
Comparing two pain medicines for gynecologic cancer surgery
This trial compares two different pain medicines (methadone given by mouth or IV vs. hydromorphone given through a spinal injection) after surgery for gynecologic cancer. It aims to find which option provides better pain relief with fewer side effects.
Rochester, MinnesotaAges Any age - NCT07536399RecruitingPhase 3
Bone Marrow Treatment for Jaw Joint Pain Relief
This study tests whether injecting your own bone marrow cells into your jaw joint during a minimally invasive procedure can reduce pain and improve jaw function better than arthroscopy alone. It's for people with significant jaw pain that hasn't improved with conservative treatments like NSAIDs, physical therapy, and bite splints.
New York, New YorkAges 18–75 - NCT06365892Recruiting
Open-label placebo for pain after scoliosis surgery
This trial tests whether taking a placebo pill that you know is a placebo (open-label placebo) can help reduce pain after spinal fusion surgery for scoliosis. It compares the placebo to standard care in adolescents aged 11-17.
San Francisco, CaliforniaAges 10–18 - NCT05271331Recruiting
Numbing injection options for back surgery pain
This trial compares two ways of numbing tissue during a planned back surgery called a laminectomy: an “ESPB block” versus numbing the wound directly. It aims to see which method works better for pain control and comfort after surgery.
Padova, VenetoAges 18 years+ - NCT06243718Recruiting
Surgery for paralyzed diaphragm nerve
This trial looks at how patients feel and recover after surgery to fix the nerve that controls the diaphragm. It aims to learn about people's experiences to improve care for diaphragmatic paralysis.
Red Bank, New JerseyAges 18–70 - NCT06852248Recruiting
Green dye vs. ureter stent for endometriosis surgery
This trial compares two ways of protecting the ureter during deep endometriosis surgery: placing a small tube (stent) versus using a green dye (indocyanine green) to see the ureter. The goal is to see if the dye works just as well but causes less pain and fewer side effects afterward.
Stoke-on-Trent, StaffordshireAges 18–50 - NCT07239817Recruiting
Nerve block plus numbing medicine for hip fracture surgery
This study tests a special nerve block (PENG block) combined with a numbing medicine injection around the hip joint to provide better pain relief after hip replacement surgery for a broken hip. It aims to see if this approach can reduce pain and the need for strong pain medicines.
MilanAges 18 years+ - NCT07313566Recruiting
Rehab pathway vs usual care after lumbar spine surgery
This trial compares a new rehab program called R3 (which includes pre-surgery preparation and post-surgery recovery support) with standard care for people having lumbar spine surgery. It aims to see if the R3 pathway helps you recover better and return to work faster.
AntwerpAges 18–65
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Common questions
- Are there clinical trials for pain after surgery?
- Yes. Clin2 currently lists 419 recruiting pain after surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain after surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain after surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.