Clinical trials · Philadelphia, PA
Pain clinical trials in Philadelphia
We’re tracking 42 recruiting pain studies with a site in or near Philadelphia — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Philadelphia
- NCT03858205Recruiting
Low-dose radiation to relieve pain from bone tumors
This trial studies whether low-dose radiation can reduce pain from a specific bone lesion caused by multiple myeloma. It may help people whose main problem is painful bone metastasis, with targeted treatment to the painful spot.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07102641RecruitingPhase 4
Comparing pain relief methods after c-section
This study compares two ways of giving pain medication after a cesarean section to see which works better. It may help find the best approach to manage pain after surgery while reducing the need for stronger medications.
Philadelphia, PennsylvaniaAges 16 years+ - NCT06539741Recruiting
Ibuprofen response study for wisdom tooth removal
This study looks at how people respond to ibuprofen after having one or more impacted wisdom teeth removed. It aims to understand why pain relief varies between individuals.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06575010Enrolling by invitationPhase 4
Comparing pain relief methods for rotator cuff repair surgery
This trial tests two different pain relief methods for people having rotator cuff repair surgery. The goal is to see which one works better for managing pain after surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06914557RecruitingPhase 2
Scrambler therapy plus duloxetine for chemo nerve pain
This study tests whether adding a non-invasive device called Scrambler Therapy to the usual nerve pain medicine (duloxetine) can better relieve chemotherapy-induced nerve pain. It is for people with cancer who still have significant nerve pain despite taking duloxetine.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07211386Recruiting
Nerve block for severe cancer-related abdominal pain
This study tests whether a nerve block, called an erector spinae plane block, can reduce severe abdominal pain in people with gastrointestinal cancer who come to the emergency room. If you have cancer in your digestive system and are in pain that isn't controlled, this trial may help.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06665997RecruitingPhase 4
Depot shot for pain in women with sickle cell disease
This study tests if a hormone shot (depot medroxyprogesterone acetate) can help reduce pain episodes in women with sickle cell disease. It aims to see if the shot improves pain and markers of inflammation.
Philadelphia, PennsylvaniaAges 18–50 - NCT05722002RecruitingPhase 4
Compare pain-med plans after low-risk surgery
This study tests which pain-medication plan works best and has the fewest side effects after certain low-risk surgeries. You may be assigned to receive opioid-based, NSAID-based, or acetaminophen-based pain control depending on your situation.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05991453Recruiting
Recovery after IV vs. inhaled anesthesia for non-cardiac surgery
This trial compares recovery after two types of general anesthesia: one given through an IV (propofol) and one inhaled as a gas. It aims to see which approach leads to a smoother recovery for people having non-cardiac surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT02463266Recruiting
PACE/PACENET program outcomes study for people 65+
This study looks at how well the PACE/PACENET care program works for older adults over time. If you join, you’ll provide consent for a check-in about your outcomes about 3 months after the acute (most intense) phase of care ends, with follow-up around 6 months.
Philadelphia, PennsylvaniaAges 65 years+ - NCT06350409Recruiting
Opioid use after surgery in teens
This study looks at how teens aged 12–17 use opioids after a scheduled surgery. It aims to understand outcomes and help improve pain management.
Philadelphia, PennsylvaniaAges 12–17 - NCT06465992Enrolling by invitationPhase 4
Liposomal bupivacaine with dexamethasone for foot surgery pain relief
This trial tests whether adding dexamethasone to liposomal bupivacaine in a nerve block provides better pain relief after foot or ankle surgery. If you're having foot or ankle surgery and are willing to answer a few surveys, you may be able to join.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07158736Recruiting
Nerve block for knee pain in the emergency room
This trial tests whether a nerve block can reduce knee pain in the emergency room. If you have knee pain without an injury and are at least 18 years old, this treatment may offer quick relief.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07723352Enrolling by invitation
Testing Journavx for Thumb Arthritis Surgery Pain
This trial tests a new pain medicine called Journavx (suzetrigine) for people having thumb arthritis surgery. It aims to see how well the medicine controls pain after the operation.
Philadelphia, PennsylvaniaAges 40–80 - NCT04679844Recruiting
Test bone putty for back fusion versus bone graft alternatives
This study compares a ready-to-use bone putty to standard bone graft materials (with or without your own bone) during back fusion surgery for unstable lower back problems. It looks at whether the putty works as well or better to help the bones fuse and heal.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06006624Enrolling by invitationPhase 4
Exparel vs nerve block for ACL reconstruction pain
This trial compares two methods of pain control after ACL surgery: a long-lasting local anesthetic (Exparel) versus a nerve block. It aims to find which provides better pain relief and recovery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06206252Recruiting
Can Medical Cannabis Help Reduce Opioid Use?
This study tests whether medical cannabis can help people who take opioids for long-term pain reduce their opioid use. Participants will either use medical cannabis or continue without it for 3 months.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06783946Enrolling by invitation
Meditation for pain and anxiety after kidney stone surgery
This study is testing whether guided meditation can help reduce pain, discomfort, and anxiety after a kidney stone removal procedure called ureteroscopy. If you or your child is a teenager or adult scheduled for this surgery, meditation might be a calming tool to try before and after the procedure.
Philadelphia, PennsylvaniaAges 12 years+ - NCT07425691Recruiting
A program for teens with chronic pain and their parents
This study offers a program to help teens with chronic pain learn skills to manage their pain and improve daily life. The program includes both the teen and a parent, so it's a team effort.
Philadelphia, PennsylvaniaAges 10–17 - NCT06484192Enrolling by invitationPhase 4
Pain control after lower back fusion surgery
This trial tests a new pain management plan for people having spinal fusion surgery on their lower back. It aims to find the best way to control pain while reducing side effects.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06994442RecruitingPhase 3
Best pain relief for children on a breathing tube
This study tests adding extra pain medicines (acetaminophen or an NSAID) to usual opioid pain treatment for children on a breathing machine. The goal is to find the safest and most effective way to manage pain.
Philadelphia, PennsylvaniaAges 2 months–17 years - NCT06992427RecruitingPhase 3
Gabapentin to prevent opioid use for mouth pain during cancer treatment
This trial tests if taking gabapentin during chemoradiation for head and neck cancer can reduce the need for strong painkillers like opioids. It may help manage mouth pain caused by treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07743606Enrolling by invitationPhase 3
Pain medicine after lower back fusion surgery
This study tests whether taking a nonsteroidal anti-inflammatory drug (NSAID) like ibuprofen after lumbar spine fusion surgery is safe and helps with pain without affecting bone healing. It may offer an alternative to stronger pain medicines.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04984291Recruiting
Study of shoulder replacement implants for eligible adults
This trial looks at a specific shoulder replacement implant and follow-up care for people who need a shoulder arthroplasty (shoulder replacement) for certain joint problems or fractures. You may be a candidate if you can take part in required visits and your shoulder muscles and bone are suitable.
Philadelphia, PennsylvaniaAges 20 years+
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Pain trials in other cities
Where these studies are running near Philadelphia
Institutions with a site for the recruiting pain studies listed above.
- Rothman Orthopaedic Institute · 8 studies
- University of Pennsylvania · 7 studies
- Children's Hospital of Philadelphia · 5 studies
- Thomas Jefferson University Hospital · 3 studies
- Penn Presbyterian Medical Center · 2 studies
- Pennsylvania Hospital · 2 studies
- Asplundh Cancer Pavilion
- Cooper University Health Care
What taking part in a pain study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting pain studies in Pennsylvania.
Common questions
- Are there pain clinical trials near Philadelphia?
- Yes. We're currently tracking 42 recruiting pain studies with a site near Philadelphia, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a pain study near Philadelphia?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Philadelphia to take part?
- Not necessarily. These studies have a site near Philadelphia, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New pain studies open near Philadelphia regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.