Clinical trials · Pennsylvania
Pain clinical trials in Pennsylvania
We’re tracking 76 recruiting pain studies with a site in Pennsylvania — including Early Phase 1, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT05658575RecruitingPhase 2/Phase 3
Tablets to treat sudden gout flare pain
This trial studies dapansutrile tablets (OLT1177) to see how well they work for people in the first 4 days of an acute gout flare. It may help reduce pain and inflammation in the specific joint where your gout is flaring.
Duncansville, PennsylvaniaAges 18 years+ - NCT05722002RecruitingPhase 4
Compare pain-med plans after low-risk surgery
This study tests which pain-medication plan works best and has the fewest side effects after certain low-risk surgeries. You may be assigned to receive opioid-based, NSAID-based, or acetaminophen-based pain control depending on your situation.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05862792Recruiting
Liposomal bupivacaine during robotic throat surgery
This study gives a pain-relief medicine (bupivacaine in a slow-release form) during transoral robotic throat surgery. It aims to see if it improves comfort and pain control around the time of surgery.
Danville, PennsylvaniaAges 18 years+ - NCT05991453Recruiting
Recovery after IV vs. inhaled anesthesia for non-cardiac surgery
This trial compares recovery after two types of general anesthesia: one given through an IV (propofol) and one inhaled as a gas. It aims to see which approach leads to a smoother recovery for people having non-cardiac surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06350409Recruiting
Opioid use after surgery in teens
This study looks at how teens aged 12–17 use opioids after a scheduled surgery. It aims to understand outcomes and help improve pain management.
Philadelphia, PennsylvaniaAges 12–17 - NCT06539741Recruiting
Ibuprofen response study for wisdom tooth removal
This study looks at how people respond to ibuprofen after having one or more impacted wisdom teeth removed. It aims to understand why pain relief varies between individuals.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06559852Recruiting
Yoga for endometriosis pain relief study
This study tests whether a 12-week yoga program can reduce pain in women with endometriosis. It requires that your diagnosis was confirmed by surgery and that you’re not already doing yoga.
Hershey, PennsylvaniaAges 18–45 - NCT06603662RecruitingPhase 4
Steroids for sudden osteoarthritis pain in the emergency room
This trial tests if a short course of oral steroids (glucocorticoids) can relieve sudden osteoarthritis pain in the knee, hip, or shoulder for people who come to the emergency department and are well enough to go home.
York, PennsylvaniaAges 18 years+ - NCT06626334Recruiting
Blue light for pain and inflammation after rib fractures
This trial tests if wearing blue light can reduce pain and inflammation after breaking one or more ribs. It may help you need less pain medicine and recover faster.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06665997RecruitingPhase 4
Depot shot for pain in women with sickle cell disease
This study tests if a hormone shot (depot medroxyprogesterone acetate) can help reduce pain episodes in women with sickle cell disease. It aims to see if the shot improves pain and markers of inflammation.
Philadelphia, PennsylvaniaAges 18–50 - NCT06731998Recruiting
Improving pain control after cancer surgery
This study compares different methods of managing pain after minimally invasive surgery for abdominal cancers. It aims to find which approach works best to reduce pain and improve recovery.
Pittsburgh, PennsylvaniaAges 18–89 - NCT06830876Recruiting
Testing muscle stimulator for pain and function after leg amputation
This trial tests if a noninvasive electrical stimulator (NMES) placed on the residual leg can reduce pain and improve muscle and function in people with a below-knee amputation. It aims to offer a drug-free option for managing chronic limb pain.
Pittsburgh, PennsylvaniaAges 18–100 - NCT06914557RecruitingPhase 2
Scrambler therapy plus duloxetine for chemo nerve pain
This study tests whether adding a non-invasive device called Scrambler Therapy to the usual nerve pain medicine (duloxetine) can better relieve chemotherapy-induced nerve pain. It is for people with cancer who still have significant nerve pain despite taking duloxetine.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06915012Recruiting
Test of light therapy for long-term severe arthritis pain
This study tests a non-drug therapy called biophoton therapy to see if it can reduce chronic severe arthritis pain. It may be an option if you've had pain for at least 3 months and are not using certain medical implants.
Butler, PennsylvaniaAges 18–80 - NCT06992427RecruitingPhase 3
Gabapentin to prevent opioid use for mouth pain during cancer treatment
This trial tests if taking gabapentin during chemoradiation for head and neck cancer can reduce the need for strong painkillers like opioids. It may help manage mouth pain caused by treatment.
Dickson City, PennsylvaniaAges 18 years+ - NCT07044323Recruiting
Virtual reality for phantom limb pain after leg amputation
This study tests whether using virtual reality at home for 30 minutes a day can reduce phantom limb pain after a leg amputation. It aims to improve how your brain handles pain signals.
Philadelphia, PennsylvaniaAges 18–100 - NCT07221786Recruiting
Opioid reduction before spine surgery
This trial tests whether slowly reducing opioid pain medications before spine surgery can lead to a better recovery afterward. It is for adults already taking daily opioids who have major spine surgery planned at least a month away.
Philadephia, PennsylvaniaAges 18 years+ - NCT07290205RecruitingEarly Phase 1
Remimazolam brain imaging study
This study uses brain scans to see how a new sedative called remimazolam affects the brain in healthy adults. It will help researchers understand the drug's effects and ensure it's safe.
Pittsburgh, PennsylvaniaAges 18–59 - NCT07294092RecruitingEarly Phase 1
Brain imaging study of ketamine and propofol
This study uses MRI scans to see how two common sedatives, ketamine and propofol, affect brain activity. It may help explain how these drugs work differently in the brain.
Pittsburgh, PennsylvaniaAges 18–59 - NCT01550575Recruiting
Study of outcomes in people treated with Boston Scientific devices
This study looks back at what happened to patients after treatment (or if they could have used) Boston Scientific medical devices. It may help improve how these devices are used and understand real-world results.
Danville, PennsylvaniaAges 18 years+ - NCT02844738RecruitingPhase 2
Cell therapy for shoulder osteoarthritis pain and inflammation
This trial tests a treatment using your own (autologous) regenerative cells to reduce pain and inflammation from shoulder osteoarthritis. It may help people with long-lasting shoulder pain, but you must meet several health and medication timing requirements.
Grove City, PennsylvaniaAges 18–90 - NCT02844764RecruitingPhase 2
Cell therapy test for hip osteoarthritis pain and swelling
This trial tests an “autologous” regenerative cell treatment, meaning cells taken from you, to reduce hip osteoarthritis pain and inflammation. It checks safety first and looks for improvements in how you feel and move.
Grove City, PennsylvaniaAges 18–90 - NCT02844751RecruitingPhase 2
Regenerative knee cell therapy for arthritis pain and swelling
This Phase 2 study tests a patient’s own (autologous) regenerative cell treatment to reduce knee pain and inflammation from osteoarthritis. It mainly looks at whether the treatment is safe and whether it can improve symptoms over time.
Grove City, PennsylvaniaAges 18–90 - NCT02463266Recruiting
PACE/PACENET program outcomes study for people 65+
This study looks at how well the PACE/PACENET care program works for older adults over time. If you join, you’ll provide consent for a check-in about your outcomes about 3 months after the acute (most intense) phase of care ends, with follow-up around 6 months.
Philadelphia, PennsylvaniaAges 65 years+
Pain trials by city in Pennsylvania
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting pain studies listed above.
- University of Pennsylvania · 4 studies
- Geisinger Medical Center · 3 studies
- VivaTech International, Inc. · 3 studies
- Children's Hospital of Philadelphia · 2 studies
- Thomas Jefferson University Hospital · 2 studies
- University of Pittsburgh · 2 studies
- Allegheny General Hospital
- Allegheny Health Network Saint Vincent Hospital
What taking part in a pain study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Pain trials in other states
Common questions
- Are there pain clinical trials in Pennsylvania?
- Yes. We're currently tracking 76 recruiting pain studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a pain study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New pain studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.