Clinical trials · Pennsylvania
Pain clinical trials in Pennsylvania
We’re tracking 76 recruiting pain studies with a site in Pennsylvania — including Phase 1, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT03858205Recruiting
Low-dose radiation to relieve pain from bone tumors
This trial studies whether low-dose radiation can reduce pain from a specific bone lesion caused by multiple myeloma. It may help people whose main problem is painful bone metastasis, with targeted treatment to the painful spot.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04996628Recruiting
Testing nerve pain signals to guide treatment for chronic pancreatitis pain
This study checks how your nerves respond to controlled touch and temperature tests, to help predict how well you’ll respond to procedures that relieve blockage in the main pancreatic duct. It may help doctors choose the most effective treatment for chronic pancreatitis pain.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06100822RecruitingPhase 1
Testing metformin for chronic Achilles tendon pain
This study tests whether a common diabetes medication, metformin, can help people with chronic Achilles tendon pain. If you have this condition and meet certain health requirements, you may be able to join.
Pittsburgh, PennsylvaniaAges 18–50 - NCT06206252Recruiting
Can Medical Cannabis Help Reduce Opioid Use?
This study tests whether medical cannabis can help people who take opioids for long-term pain reduce their opioid use. Participants will either use medical cannabis or continue without it for 3 months.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06374238Recruiting
Peer Support for Young People with Sickle Cell Pain
This study is testing a peer support program for teens and young adults (ages 16–30) with sickle cell disease who have chronic pain. You'll connect with a trained peer supporter through your smartphone to learn pain coping skills and get support.
Pittsburgh, PennsylvaniaAges 16–30 - NCT07006675RecruitingPhase 3
NSAIDs for Tibia Fracture Pain and Healing Study
This study tests whether NSAID pain relievers (like ibuprofen) affect bone healing after a broken tibia and if they can help reduce the need for stronger painkillers. If you qualify, you could help doctors learn the safest way to manage pain after this common injury.
Pittsburgh, PennsylvaniaAges 18–80 - NCT07102641RecruitingPhase 4
Comparing pain relief methods after c-section
This study compares two ways of giving pain medication after a cesarean section to see which works better. It may help find the best approach to manage pain after surgery while reducing the need for stronger medications.
Philadelphia, PennsylvaniaAges 16 years+ - NCT07211386Recruiting
Nerve block for severe cancer-related abdominal pain
This study tests whether a nerve block, called an erector spinae plane block, can reduce severe abdominal pain in people with gastrointestinal cancer who come to the emergency room. If you have cancer in your digestive system and are in pain that isn't controlled, this trial may help.
Philadelphia, PennsylvaniaAges 18 years+ - NCT01719055Recruiting
Long-term follow-up for Boston Scientific pain nerve stimulation
This study looks at how well a Boston Scientific nerve stimulation device works over the long term for pain in everyday care. You may be able to join if you’re already being set up to use one of these approved systems and can reliably report your pain outcomes.
Trevose, PennsylvaniaAges 18 years+ - NCT06783946Enrolling by invitation
Meditation for pain and anxiety after kidney stone surgery
This study is testing whether guided meditation can help reduce pain, discomfort, and anxiety after a kidney stone removal procedure called ureteroscopy. If you or your child is a teenager or adult scheduled for this surgery, meditation might be a calming tool to try before and after the procedure.
Philadelphia, PennsylvaniaAges 12 years+ - NCT06484192Enrolling by invitationPhase 4
Pain control after lower back fusion surgery
This trial tests a new pain management plan for people having spinal fusion surgery on their lower back. It aims to find the best way to control pain while reducing side effects.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Hershey, PennsylvaniaAges birth–20 years - NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Altoona, PennsylvaniaAges 45–80 - NCT07353931RecruitingPhase 3
Study of eloralintide for knee osteoarthritis pain in people with overweight or obesity
This trial tests an investigational drug called eloralintide to see if it can reduce knee pain in people with osteoarthritis who also have overweight or obesity. You may be able to join if you have knee osteoarthritis, a BMI of 27 or higher, and have tried to lose weight with diet before.
Plymouth Meeting, PennsylvaniaAges 18 years+ - NCT06994442RecruitingPhase 3
Best pain relief for children on a breathing tube
This study tests adding extra pain medicines (acetaminophen or an NSAID) to usual opioid pain treatment for children on a breathing machine. The goal is to find the safest and most effective way to manage pain.
Hershey, PennsylvaniaAges 2 months–17 years - NCT06013878Recruiting
Testing a tool for caregivers who help with transfers
This study tests a special instrument to measure how caregivers help people with physical disabilities move from one place to another (transfers). It may help improve safety and technique for both caregivers and care recipients.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT03434392Recruiting
Testing pain-sensing to predict treatment response in chronic pancreatitis
This study uses a special pain-testing method to better predict how people with chronic pancreatitis-related pain (or similar conditions) will respond to treatment. It may help doctors choose therapies that work better for each person’s type of pain.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT03876054Recruiting
Tracking outcomes after Abbott neurostimulator implantation
This study follows people long-term after they get an Abbott device implanted to help with chronic pain. It aims to learn how well the therapy works in real-world care over time.
Exton, PennsylvaniaAges 18 years+ - NCT04679844Recruiting
Test bone putty for back fusion versus bone graft alternatives
This study compares a ready-to-use bone putty to standard bone graft materials (with or without your own bone) during back fusion surgery for unstable lower back problems. It looks at whether the putty works as well or better to help the bones fuse and heal.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04984291Recruiting
Study of shoulder replacement implants for eligible adults
This trial looks at a specific shoulder replacement implant and follow-up care for people who need a shoulder arthroplasty (shoulder replacement) for certain joint problems or fractures. You may be a candidate if you can take part in required visits and your shoulder muscles and bone are suitable.
Philadelphia, PennsylvaniaAges 20 years+ - NCT05437575RecruitingPhase 3
Testing pain medicine given before arrival to a trauma center
This study tests whether giving pain medicine soon after an injury (before you reach the trauma center) improves comfort and care. You might be eligible if you’re transported to a participating trauma center and meet specific shock and pain levels.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05452694Recruiting
Personalized pain relief after back fusion surgery
This trial tests a personalized plan to manage pain after lumbar (lower back) fusion and decompression surgery. It may help reduce difficult pain while guiding safe use of opioids around the time of surgery.
Pittsburgh, PennsylvaniaAges 18–99 - NCT05504499Recruiting
Test a new implant for low back pain with mild narrowing
This trial studies a new spine implant placed between the bones to help relieve low back pain. You may be a candidate if imaging shows mild-to-moderate spinal narrowing and you’ve already tried non-surgical treatments for at least 3 months.
Chadds Ford, PennsylvaniaAges 18 years+ - NCT05525923Recruiting
Personalized pain plan after chest surgery in adults
This trial tests a personalized (tailored) plan to manage pain after thoracic (chest) surgery. It may help improve comfort and recovery by matching pain treatment to your situation after surgery.
Pittsburgh, PennsylvaniaAges 18–99
Pain trials by city in Pennsylvania
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting pain studies listed above.
- Rothman Orthopaedic Institute · 3 studies
- University of Pennsylvania · 3 studies
- University of Pittsburgh · 3 studies
- Children's Hospital of Philadelphia · 2 studies
- Thomas Jefferson University Hospital · 2 studies
- University of Pittsburgh Medical Center · 2 studies
- UPMC Presbyterian Hospital · 2 studies
- Allegheny General Hospital
What taking part in a pain study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Pain trials in other states
Common questions
- Are there pain clinical trials in Pennsylvania?
- Yes. We're currently tracking 76 recruiting pain studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a pain study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New pain studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.