Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06494670Enrolling by invitation
Trends in muscle and bone pain in U.S. adults
This study looks at how common different types of muscle and bone pain have been in U.S. adults over time. It uses data from a national health survey to understand trends, which may help improve pain care.
Ages Any age - NCT05861609Recruiting
Tapering pain meds for nerve pain after spinal cord stimulation
This study helps people with persistent nerve pain in the low back or legs who are planned to start spinal cord stimulation (SCS). It tests a careful plan to reduce (taper) opioid pain medicines using specific replacement medicines, while monitoring safety and pain control.
JetteAges 18 years+ - NCT07277517Recruiting
Pain education plus physical therapy for new back pain
This study tests whether adding Pain Neuroscience Education (learning how your brain and nerves process pain) to standard physical therapy can help people with new low back pain feel better and move more easily. It's for adults whose pain started within the past 6 weeks and who do not have a serious spine condition.
TehranAges 18 years+ - NCT07001449Recruiting
Pain education for chronic muscle or joint pain
This study tests a type of pain education that focuses on communication to help people with long-term muscle or joint pain. It aims to see if learning about pain in a new way can help reduce symptoms and improve quality of life.
Lamia, Central GreeceAges 18–65 - NCT06709963Recruiting
Brain stimulation for older adults with chronic back or knee pain
This study tests a type of brain stimulation called intermittent theta burst stimulation to see if it can reduce pain and improve thinking in older adults with long-term back or knee pain. The treatment involves a non-invasive procedure that uses magnetic pulses to stimulate the brain.
Hong KongAges 60–85 - NCT06800209RecruitingPhase 2
Pain Reprocessing Therapy for ongoing knee pain after replacement
This study tests if Pain Reprocessing Therapy can help reduce knee pain that continues 3 months after a knee replacement. It uses a telehealth approach so you can participate from home.
Aurora, ColoradoAges 18 years+ - NCT04811209Recruiting
Testing better pain control and recovery after orthopedic surgery
This trial looks at how well a pain-control plan works after certain orthopedic surgeries and how it affects recovery and patient-reported outcomes. It may help determine what level of pain relief is meaningful to patients after surgery.
Toronto, OntarioAges 18–80 - NCT07562412Recruiting
Audio Mindfulness for Quick Pain Relief
This study tests whether listening to brief guided mindfulness audio recordings can help reduce acute (sudden, short-term) pain. Researchers will see how different amounts of listening affect pain levels.
Tallahassee, FloridaAges 18 years+ - NCT04982965RecruitingEarly Phase 1
Study brain changes behind cannabis pain relief
This early study looks at how the brain may respond to cannabis to reduce long-lasting lower back pain. You may be asked to follow strict rules about cannabis, opioids, and safety checks (including MRI) to help researchers understand the brain mechanisms.
La Jolla, CaliforniaAges 21–65 - NCT05953155Recruiting
Yoga for chronic back pain with a poorer outlook
This trial studies whether a yoga program can reduce symptoms and improve function for people with long-lasting, non-specific back pain and a poorer prognosis. You may be eligible if your back pain has lasted at least 3 months and you meet certain pain and questionnaire scores.
Belo Horizonte, Minas GeraisAges 18–60 - NCT06208514Recruiting
Brief Pain Exposure Therapy for chronic pain conditions
This study tests a type of talk therapy called Brief Pain Exposure Therapy (BPET) for people with certain chronic pain conditions like fibromyalgia, lupus, or chronic low back pain. It aims to help reduce pain by changing how your brain responds to it.
Ann Arbor, MichiganAges 18 years+ - NCT06299683Recruiting
Pain type and bladder pain syndrome treatment study
This study is testing if the type of pain you feel can help predict which treatments work best for interstitial cystitis (a condition that causes bladder pain and pressure). It may help match you with more effective care.
Franklin, TennesseeAges 18 years+ - NCT06387290RecruitingPhase 3
Mindfulness and pain management for chronic pain on opioids
This study tests whether adding mindfulness training to standard pain management visits can help people with chronic pain who are taking long-term opioids. It aims to improve pain relief and reduce opioid-related risks.
La Jolla, CaliforniaAges 18 years+ - NCT06466941Recruiting
Understanding acute pain after surgery
This study surveys surgical patients about their pain and emotional experience to better understand acute pain. You may help by answering questions or sharing your story.
Boston, MassachusettsAges 18 years+ - NCT06480786Recruiting
Spinal cord stimulator for diabetic nerve and artery pain
This study tests if a spinal cord stimulator (a device that sends mild electrical pulses to the spine) can relieve severe leg pain caused by diabetic nerve damage and poor blood flow. It may help people who have not found enough relief from other treatments.
Omaha, NebraskaAges 19–89 - NCT06555107Recruiting
Pain before emergency surgery and long-term pain after
This study looks at whether pain you feel before emergency surgery affects long-term pain after the surgery. It may help doctors find ways to prevent chronic pain in patients who have emergency orthopedic (bone/joint) or abdominal (belly) surgery.
AmiensAges 18 years+ - NCT06590181Recruiting
Yoga Nidra with acceptance for chronic pain relief
This study tests a deep relaxation practice called Yoga Nidra, combined with mental imagery and acceptance, to see if it helps with long-lasting pain. You will take part in guided sessions from home via the internet.
Orlando, FloridaAges 18–75 - NCT06609772Recruiting
Pain education for liver donors after surgery
This trial tests an individualised pain education program to see if it can reduce chronic pain and improve quality of life for living liver donors after their surgery.
Malatya, BattalgaziAges Any age - NCT06835868Recruiting
Registry for nerve stimulation treatments for chronic pain in Belgium
This trial creates a registry for people with chronic pain who are getting special nerve-modulating treatments in Belgium. It focuses on two specific chronic pain conditions: Persistent Spinal Pain Syndrome Type 2 (pain after spine surgery) and Complex Regional Pain Syndrome (a type of nerve pain).
Edegem, AntwerpAges Any age - NCT06940986Recruiting
Holistic pain self-management for military health system patients
This trial tests a holistic pain self-management program for people with long-term muscle or bone pain. It aims to help you take control of your pain through education and support, without relying only on medications.
Fairbanks, AlaskaAges 18 years+ - NCT06984354Recruiting
Digital treatments for chronic low back pain
This trial tests a smartphone app to help people with long-term low back pain. It aims to see if digital treatments can reduce pain and improve daily function.
Randwick, New South WalesAges 18 years+ - NCT06996015Recruiting
SNAGs and CBT for neck pain relief
This study tests whether combining two hands-on techniques (SNAGs and CBT) can reduce neck pain, improve head posture, and help you move better. It's for people with moderate neck pain that hasn't been treated recently.
Faisalabad, Punjab ProvinceAges 18–28 - NCT07032350Recruiting
Pain management app for dementia caregivers
This study tests a mobile app that helps family caregivers of people with dementia manage their loved one's chronic pain. It aims to see if the app is easy to use and helpful for caregivers.
Iowa City, IowaAges 18–100 - NCT07067619Recruiting
Pain acceptance training for emotional and physical distress
This trial tests a training program to help people accept chronic pain and emotional distress. It looks at how thinking patterns might help or hinder progress.
HaifaAges 18–70
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.