Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 271 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07053969Recruiting
Does a protein gel thicken gum tissue around implants?
This study tests whether a protein-based gel (enamel matrix derivative) can make the gum tissue thicker during a second-stage implant procedure. It may help people getting dental implants achieve better healing and gum support.
San Antonio, TexasAges 18–18 - NCT07048028Recruiting
Chitosan rinse for root canals in premolars
This study tests a new natural mouth rinse (chitosan) during root canal treatment for lower premolar teeth. Researchers want to see if it helps clean the tooth better than standard treatment.
Ordu, AltınorduAges 18 years+ - NCT07030088Recruiting
Testing a new two-sided toothbrush for healthier gums
This trial tests a special toothbrush that cleans both sides of your teeth at once. It compares this new brush to a regular one to see if it improves gum health in dentists.
RiyadhAges 25–40 - NCT07019298Recruiting
Comparing dental filling methods for root canals
This trial studies different ways to fill a root canal after treatment to see which works best. It may help if you have a tooth with an infected or dying nerve.
Madrid, SpainAges 18 years+ - NCT07018284Recruiting
Pain after root canal filling with different sealers
This study compares pain levels after root canal treatment using two different types of sealer material. It aims to find which sealer may cause less discomfort.
MadridAges 18 years+ - NCT06959602Enrolling by invitation
Comparing two root canal cleaning methods for infected teeth
This trial compares two ways of cleaning infected root canals during a root canal procedure. The goal is to see which method better removes bacteria and improves healing.
AthensAges 18–80 - NCT06948162Recruiting
Dental MRI for routine dental care
This study tests whether a special MRI machine can take detailed images of teeth and jaws for routine dental care. It may help find problems without using X-rays.
Minneapolis, MinnesotaAges 18 years+ - NCT06934291Recruiting
Comparing ultrasonic tools for deep gum cleaning
This trial tests two types of ultrasonic tools (piezoelectric vs magnetostrictive) for full-mouth deep gum cleaning in people with mild to moderate gum disease (periodontitis stages 1 and 2). It aims to see which tool works better for removing plaque and tartar.
Siena, SIAges 18–80 - NCT06914596Recruiting
Pocket cleaning aid for gum disease after deep cleaning
This study tests a new device called Emanate Perio PODS that you use at home for 30 minutes twice a day after a deep cleaning procedure. It aims to help reduce gum pockets and improve gum health.
Fullerton, CaliforniaAges 30–75 - NCT06875440Enrolling by invitation
Green tea vs. chlorhexidine mouthwash for gum disease
This trial tests if green tea mouthwash works as well as a standard mouthwash (chlorhexidine) for treating gum inflammation. It also checks how the mouthwash affects certain cells and chemicals in your spit that are linked to gum health.
Tehran, Tehran, Iran.Ages 18–40 - NCT06843525Recruiting
Bite force measurements for molar dental work
This trial measures how your bite force changes after getting a filling or root canal on a lower back tooth. It helps doctors understand if different dental treatments affect your ability to chew.
Newark, New JerseyAges 18–89 - NCT06831487Enrolling by invitation
Gum disease imaging study with new microscope
This study uses a new type of imaging (like an advanced microscope) to look at gum tissue in people with healthy gums, gingivitis, or periodontitis. It aims to see if the imaging can tell the difference and help with diagnosis.
Catania, ItalyAges 18–75 - NCT06830200Recruiting
Treating infected dental implants with a chitosan brush
This study tests a new treatment for infected dental implants using a small brush made of chitosan (a natural material from shellfish). It aims to clean the implant surface and help the infection heal.
AnkaraAges 18–65 - NCT06781229Recruiting
Gum bacteria in people preparing for weight loss surgery
This trial looks at the bacteria in the mouths of people with a BMI of 30 or higher who are scheduled for weight-loss surgery. The goal is to understand how gum health and body weight are connected.
ToulouseAges 18 years+ - NCT06731465Enrolling by invitation
Clear aligners vs braces for crowded lower front teeth
This study compares clear aligners (removable trays) to traditional braces for treating crowded lower front teeth. It aims to see which method works better and is more comfortable for patients.
Sharjah city, Emirate of SharjahAges 16–45 - NCT06286501Recruiting
Preventive treatment for teens at risk of oral diseases
This trial tests a new preventive treatment for teenagers at risk of tooth decay and gum disease. It uses a special mouthpiece device (Lumoral) to clean teeth better and see if it can prevent oral health problems.
Tampere, PirkanmaaAges 14–16 - NCT06270303Recruiting
Bone substitute for gum disease between tooth roots
This trial tests a bone substitute material to help repair gum defects between the roots of back teeth (molars) that have not healed with standard deep cleaning. If you have a single area of gum bone loss between the roots, this surgery might help regenerate the bone.
GothenburgAges 18 years+ - NCT06545084Recruiting
Better healing after root-end surgery using a special blood clot
This study tests whether adding a concentrated blood clot (L-PRF) to standard root-end surgery helps tooth-related infections heal faster and better. You may be a good fit if you have a persistent infection at the tip of a tooth root and need this type of surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06574152Recruiting
Light therapy for pain relief after dental root surgery
This trial tests whether a special light treatment, called photobiomodulation, can help reduce pain and speed up healing after a specific type of dental surgery on the root of a tooth. The surgery involves a small cut in the gum, and the light may help the gum recover faster.
Houston, TexasAges 18 years+ - NCT06576622Recruiting
Periodontal disease, bacteria, and miscarriage
This study looks at whether gum disease and oral bacteria are linked to repeated pregnancy loss. If you have had multiple miscarriages, your gum health may play a role.
ToulouseAges Up to 18 years - NCT06555029Recruiting
Oral health help for older adults on Medicaid
This trial is testing an oral health program offered during routine primary care visits for older adults (55+) on Medicaid. It aims to see if adding dental care support to regular check-ups can improve health.
Cleveland, OhioAges 55 years+ - NCT06480825Recruiting
Ultrasound study of gum tissue
This study uses a special high-frequency ultrasound to take detailed pictures of your gum tissue. It may help doctors understand gum disease better and find new ways to treat it.
Pisa, ItalyAges 18–70 - NCT06315855Recruiting
Oral Health Program for Cancer Survivors
This study tests a program to help cancer survivors improve their oral health using a smartphone app. It's for survivors who are at least 6 months past treatment and have not had head, neck, or mouth cancer.
Washington D.C., District of ColumbiaAges 25–75 - NCT06315348Recruiting
Gum shaping during braces with a vibration tool
This trial tests a new, less invasive surgical technique (using a special tool that vibrates, not a scalpel) to help reshape the gums while straightening teeth with braces. It is for people who need braces for mild to moderate crowding and have healthy gums.
MadridAges 16–70
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 271 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.