Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 280 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07397312Recruiting
Testing a special toothpaste on gum bacteria
This study tests whether a commercial toothpaste can reduce harmful bacteria in your mouth. It's for people with good general health who get regular dental cleanings and have a specific type of bacteria linked to gum disease.
Bietigheim-BissingenAges 18 years+ - NCT07439614Recruiting
Comparing two ways to clean a dead nerve during a root canal
This trial compares two different ways to clean a molar tooth during a root canal when the nerve is dead. The goal is to find which method is better at removing infection without causing discomfort.
Buffalo, New YorkAges 18–70 - NCT07448571Recruiting
Testing i-PRF for better root canal retreatment healing
This study tests whether using a special platelet-rich concentrate (i-PRF) during a root canal retreatment can help heal infection at the tip of the root better than standard retreatment alone. It is for adults with a previously treated upper front tooth that now shows signs of infection on X-ray.
IstanbulAges 18–50 - NCT07453576Recruiting
Comparing bleach strengths for root canal retreatment pain
This trial tests if different concentrations of sodium hypochlorite (a disinfectant used in root canals) affect pain and certain natural chemicals in the tooth during root canal retreatment. It may help find the best option to reduce discomfort.
Erzurum, ErzurumAges 18–65 - NCT07501585Recruiting
Hyaluronic acid gel for infected back tooth surgery
This trial tests whether putting hyaluronic acid (a natural gel-like substance) into the bone during root-end surgery helps heal infections in first molars (back teeth) that didn't get better after a root canal. It may be a good option if you have a small, stubborn infection and your gums are healthy.
MoscowAges 18 years+ - NCT07546279Recruiting
Bone substitutes with gum graft for deep gum pockets
This trial tests two different bone-filling materials combined with a gum graft to repair deep pockets in your gums caused by gum disease. The goal is to help your gums heal and regain support around your teeth.
MilanAges Any age - NCT07579416Recruiting
Teeth Grinding, Anxiety, and Gum Health in Dental Students
This study looks at the connection between teeth grinding (bruxism), anxiety, and gum health in dental students. Researchers want to understand how stress and grinding habits affect the teeth and gums of students in their final years of dental school.
HomsAges 18 years+ - NCT07599254RecruitingPhase 4
Pain Relief After Root Canal Retreatment
This study tests two different ways of cleaning and treating a tooth that had a root canal treatment before. Researchers want to see which method causes less pain after the procedure.
KayseriAges 18–60 - NCT07604493Recruiting
Italian Doctors' Survey on Oral Health and General Wellness
This study asks Italian general practitioners (family doctors) about their views on how oral health—like teeth and gum health—affects overall body health. Your answers help researchers understand what doctors know and think about the connection between mouth and systemic diseases.
Roma, RMAges 18 years+ - NCT07671326Recruiting
Bioceramic vs calcium hydroxide for infected molars
This study compares two types of medication placed inside a root canal to fight infection. It may be an option if you have an infected lower molar and are in generally good health.
Istanbul, IstanbulAges 18–65 - NCT07619729Enrolling by invitationPhase 4
Oral Health Program for People With Type 2 Diabetes
This study tests whether a text-message and online program about caring for your teeth and gums can help people with type 2 diabetes. Researchers want to see if better oral health habits improve overall health outcomes.
Long Island City, New YorkAges 18 years+ - NCT07389772Enrolling by invitation
Immune markers in tooth retreatments for diabetics
This study tests whether different ways of activating the immune system during root canal retreatment affect levels of certain immune markers (TLR9, IL6, IL10, TNF-alfa) in people with type 2 diabetes. If you need a repeat root canal on a front tooth or lower premolar, you may be able to join.
Kirikkale, KırıkkaleAges 18–50 - NCT07088809Enrolling by invitation
Nanoparticles with Platelet-Rich Fibrin for Gum Recession
This trial tests a new material to treat gum recession—tiny particles mixed with your own blood components (platelet-rich fibrin) placed as a membrane. The goal is to see if it helps cover exposed roots and improve gum health.
Tanta, Gharbia GovernorateAges 20–45 - NCT06959602Enrolling by invitation
Comparing two root canal cleaning methods for infected teeth
This trial compares two ways of cleaning infected root canals during a root canal procedure. The goal is to see which method better removes bacteria and improves healing.
AthensAges 18–80 - NCT06875440Enrolling by invitation
Green tea vs. chlorhexidine mouthwash for gum disease
This trial tests if green tea mouthwash works as well as a standard mouthwash (chlorhexidine) for treating gum inflammation. It also checks how the mouthwash affects certain cells and chemicals in your spit that are linked to gum health.
Tehran, Tehran, Iran.Ages 18–40 - NCT06831487Enrolling by invitation
Gum disease imaging study with new microscope
This study uses a new type of imaging (like an advanced microscope) to look at gum tissue in people with healthy gums, gingivitis, or periodontitis. It aims to see if the imaging can tell the difference and help with diagnosis.
Catania, ItalyAges 18–75
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 280 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.