Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 281 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07688421Enrolling by invitation
Short 3D-printed implants for back jaw teeth: 3-year study
This trial tests shorter implants made with 3D-printing for replacing missing teeth in the back of the mouth. Researchers will check how well they work over 3 years using X-rays.
Guarulhos, São PauloAges 18 years+ - NCT03934957Recruiting
Study of health in people living in Hamburg
This study follows adults living in Hamburg to better understand health and health-related factors over time. You may help researchers learn what influences health in this age group.
HamburgAges 45–74 - NCT04254861Recruiting
Platelet treatment for deep gum bone defects
This trial studies an “autologous platelet concentrate” (a gel made from your own blood) to help heal deep bone defects caused by periodontitis. It’s meant for adults with specific measurements in one or more gum pockets and bone areas after recent non-surgical gum treatment.
LondonAges 25–80 - NCT04605445Recruiting
One vs two dentist visits for infected root canals
This study compares whether treating an infected, dead tooth in one visit works as well as using two visits. It may help you and your dentist choose the simplest schedule while still clearing infection and supporting healing.
Vaxjo, Kronoberg CountyAges 18 years+ - NCT04805320Recruiting
Study of gum inflammation after tooth removal
This study looks at how gum (periodontal) inflammation affects the body’s immune response during wound healing after a tooth is taken out. You might be considered because you need a molar or premolar extraction where the tooth cannot be repaired.
Lincoln, NebraskaAges 21–70 - NCT04848870Recruiting
Check dental and gum health in Sjögren’s disease
This study looks at dental and gum (periodontal) health in adults with Sjögren’s syndrome. It may help researchers understand how Sjögren’s affects the mouth and how patients can be supported better.
Ivry-sur-Seine, Île-de-France RegionAges 18 years+ - NCT04851470Recruiting
Dental gum check in adults with obesity
This study looks at gum health in adults with obesity. It may help researchers understand how weight and related health factors affect periodontal (gum) status and what to monitor in bariatric care populations.
LondonAges 18 years+ - NCT05221450Recruiting
Study of what affects root canal treatment outcomes
This study looks at which factors can change how well root canal (endodontic) treatment works. It may help improve future care by understanding what leads to better healing.
LjubljanaAges 18 years+ - NCT05384132Recruiting
Dental gel trial with deep cleaning for gum disease
This study tests whether a new dental gel used along with deep gum cleaning (scaling and root planing) can improve periodontitis. If you qualify, you would receive standard gum treatment plus the study gel, then be followed over time.
Birmingham, AlabamaAges 18–85 - NCT05851248Recruiting
Gum graft treatment for a single lower front tooth
This trial studies a “free mucogingival graft,” a surgical gum tissue transplant, to cover exposed root (recession) in a specific area of the lower front teeth. If you have a deep recession in a healthy mouth with low gum bleeding, you may be able to try this approach and help researchers learn how well it works.
Murcia, MurciaAges 18 years+ - NCT06043453Recruiting
Revitalizing injured, growing permanent teeth
This trial tests a new approach to help injured, still-growing permanent teeth heal and continue to develop naturally. It may be an option if your child has a traumatized tooth with an infection and the root is not yet fully formed.
GhentAges 6–18 - NCT06252935Recruiting
Collagen membrane for gum and bone repair
This trial tests a new collagen membrane (FormaAid®) for repairing gum and bone damage from gum disease. It may help people with deep gum pockets and bone loss who are not smokers and have well-controlled health conditions.
Taipei, TaiwanAges 18–70 - NCT06270303Recruiting
Bone substitute for gum disease between tooth roots
This trial tests a bone substitute material to help repair gum defects between the roots of back teeth (molars) that have not healed with standard deep cleaning. If you have a single area of gum bone loss between the roots, this surgery might help regenerate the bone.
GothenburgAges 18 years+ - NCT06286501Recruiting
Preventive treatment for teens at risk of oral diseases
This trial tests a new preventive treatment for teenagers at risk of tooth decay and gum disease. It uses a special mouthpiece device (Lumoral) to clean teeth better and see if it can prevent oral health problems.
Tampere, PirkanmaaAges 14–16 - NCT06291350Recruiting
Mouth bacteria in gum disease with blistering condition
This study looks at the bacteria in the mouth and gut of people with a blistering gum condition (mucous membrane pemphigoid) and gum disease. It aims to understand if certain bacteria are linked to the disease, which could lead to better treatments.
NiceAges 18 years+ - NCT06315348Recruiting
Gum shaping during braces with a vibration tool
This trial tests a new, less invasive surgical technique (using a special tool that vibrates, not a scalpel) to help reshape the gums while straightening teeth with braces. It is for people who need braces for mild to moderate crowding and have healthy gums.
MadridAges 16–70 - NCT06315855Recruiting
Oral Health Program for Cancer Survivors
This study tests a program to help cancer survivors improve their oral health using a smartphone app. It's for survivors who are at least 6 months past treatment and have not had head, neck, or mouth cancer.
Washington D.C., District of ColumbiaAges 25–75 - NCT06466538RecruitingPhase 2/Phase 3
Boswellia vs standard medicine for root canal infection
This trial tests whether a natural gum resin (Boswellia) placed inside the tooth during root canal treatment can fight infection better than standard medications. It may be a good option for people with a single-rooted tooth infection who are otherwise healthy.
Al MansurahAges 20–60 - NCT06480825Recruiting
Ultrasound study of gum tissue
This study uses a special high-frequency ultrasound to take detailed pictures of your gum tissue. It may help doctors understand gum disease better and find new ways to treat it.
Pisa, ItalyAges 18–70 - NCT07088679Recruiting
Natural gel for dental implant gum disease
This trial tests a natural gel to treat gum disease around dental implants. It may help reduce bleeding and bone loss around implants.
Pavia, LombardyAges 18–70 - NCT06545084Recruiting
Better healing after root-end surgery using a special blood clot
This study tests whether adding a concentrated blood clot (L-PRF) to standard root-end surgery helps tooth-related infections heal faster and better. You may be a good fit if you have a persistent infection at the tip of a tooth root and need this type of surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06555029Recruiting
Oral health help for older adults on Medicaid
This trial is testing an oral health program offered during routine primary care visits for older adults (55+) on Medicaid. It aims to see if adding dental care support to regular check-ups can improve health.
Cleveland, OhioAges 55 years+ - NCT06566508RecruitingPhase 2/Phase 3
Gotu kola gel for root canal infections
This study tests a natural gel made from asiaticoside (a compound from the Gotu kola plant) placed inside your root canal after cleaning. This gel may help reduce infection and inflammation better than standard medicines.
Al MansurahAges 20–60 - NCT06576622Recruiting
Periodontal disease, bacteria, and miscarriage
This study looks at whether gum disease and oral bacteria are linked to repeated pregnancy loss. If you have had multiple miscarriages, your gum health may play a role.
ToulouseAges Up to 18 years
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 281 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.