Clinical trials
Periprosthetic Joint Infection clinical trials
Below are recruiting periprosthetic joint infection clinical trials, each written for real people, not researchers. We’re tracking 27 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06293352Recruiting
Comparing two antibiotic spacers for knee infection
This trial compares two types of antibiotic spacers for people with a long-term knee replacement infection. It tests whether a spacer made entirely of antibiotic cement or one with a metal core works better to treat the infection before a new knee replacement.
Chicago, IllinoisAges 18 years+ - NCT07214311RecruitingPhase 2/Phase 3
A trial of PLG0206 to prevent knee joint infection after surgery
This trial tests if a new drug called PLG0206 can stop a knee joint infection from coming back after a surgery called DAIR. DAIR cleans the infected area and keeps the artificial knee in place, and this study wants to see if adding PLG0206 helps prevent the infection from returning.
Sarasota, FloridaAges 18–80 - NCT05159739Enrolling by invitation
Study of family genetic risk for joint implant infections
This study looks at whether certain families have a higher genetic risk for infections around joint implants. It may help researchers understand who is more at risk and how to prevent these infections.
Salt Lake City, UtahAges 18–100 - NCT04858217Recruiting
Testing blood and joint fluid tests for hip or knee infection
This trial checks how accurate certain blood tests and joint-fluid (synovial) tests are at identifying infections around hip or knee replacements. It also looks at whether these tests are worth the cost, to help doctors choose the best next step.
BolognaAges 18 years+ - NCT06428448RecruitingPhase 2
Antibiotic nail for ankle infection treatment
This study tests a special antibiotic-coated nail placed inside the ankle bone to treat infections. It may help people with ankle infections avoid more serious complications.
Lansing, MichiganAges 21 years+ - NCT07599865RecruitingPhase 2
Bubble study for knee infection after joint replacement
This trial tests if a contrast agent used in ultrasound can help surgeons see pockets of infection around knee implants during revision surgery. It may help doctors do a better job cleaning out the infection.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05361941Recruiting
Antibiotic graft to help bone regrow in infected knee surgery areas
This trial tests an antibiotic “graft” placed into or near infected bone cavities around a knee replacement (TKA) to help new bone grow. You may be considered if you have an infected knee implant area and can safely take part in follow-up visits and treatment.
Los Angeles, CaliforniaAges 22 years+ - NCT06782295RecruitingPhase 4
Comparing two implant types in knee revision surgery
This study compares two types of knee implants (CCK vs PS) used during revision total knee replacement. The goal is to see which one works better in patients who need a second knee surgery.
Chicago, IllinoisAges 18 years+ - NCT06804265Recruiting
Better bacteria testing for joint implant infections
This study is testing a new, advanced lab test that can quickly identify exactly which bacteria are causing a joint implant infection. The goal is to help doctors choose the right antibiotics and improve treatment success.
BolognaAges 18 years+ - NCT05640336Enrolling by invitation
Antibiotics for early knee or hip joint infections after surgery
This study compares two antibiotic plans for acute (early) infections around an artificial knee or hip, using a procedure to clean the joint and try to keep the implant. It may help find the best approach to control infection and then prevent it from coming back with longer-term antibiotic treatment.
Jacksonville, FloridaAges 18 years+ - NCT06126614RecruitingPhase 3
Infection prevention in joint replacement surgery
This trial tests a way to prevent infections for people getting a hip or knee replacement. It compares different methods to see which works best and may help lower your risk of infection after surgery.
Hamilton, OntarioAges 18 years+ - NCT07473089Recruiting
Swiss study on joint replacement revision for infection
This study looks at people who need a second (revision) surgery on a large joint replacement like a hip, knee, shoulder, ankle, or elbow because of a suspected or confirmed infection. The goal is to learn more about these infections and improve care.
AarauAges 18 years+ - NCT06670885Enrolling by invitation
New DNA test for joint replacement infections
This trial uses advanced molecular methods to better diagnose infections in hip or knee replacement joints. The goal is to find infections more accurately so you can get the right treatment sooner.
Milan, MilanoAges 18 years+ - NCT02801253Recruiting
Study of infections around hip, knee, or shoulder implants
This study follows people who have an infection around a hip, knee, or shoulder implant (prosthesis). It uses standard infection tests (like cultures and blood tests) to confirm the diagnosis and better understand this problem after surgery.
Paris, Île-de-France RegionAges 18 years+ - NCT07653295Recruiting
Study of Tıpmed revision hip replacement safety
This study follows patients who already had a revision hip replacement using the Tıpmed system. Researchers want to confirm the implant is safe and works well over time.
BalıkesirAges 18 years+ - NCT06464770Recruiting
Improving infection prevention before shoulder surgery
This study compares different ways to clean the skin before shoulder surgery to prevent infection. It might help if you are going to have shoulder surgery and want safer, more effective infection prevention.
Seattle, WashingtonAges 18–89 - NCT05284318Recruiting
Antibiotic plans and outcomes after two-stage joint revision
This study looks at how antibiotic treatment (especially the course length and approach) relates to infection control and results after a two-step surgery for joint infections. If you’ve had a spacer placed, finished at least 6 weeks of antibiotics, and then had the second surgery, the research team may want to follow your outcomes over time.
Fuzhou, FujianAges 18 years+ - NCT06268795Recruiting
Comparing biopsy vs. aspiration for shoulder/elbow revision surgery
This study compares two methods—biopsy (taking a small tissue sample) and aspiration (drawing fluid)—to see which one better detects infection in people having repeat shoulder or elbow replacement surgery. The results will help doctors choose the best test for future patients.
Wigan, LancashireAges 18 years+ - NCT06889701RecruitingPhase 1/Phase 2
Testing TNP-2092 for knee infection after joint replacement
This trial tests a new antibiotic, TNP-2092, given as a shot directly into the knee joint for people with a persistent infection after knee replacement. It is for those whose infection is caused by certain bacteria and who are willing to stay in the hospital for 2 weeks.
Ürümqi, XinjiangAges 18 years+ - NCT07313215Recruiting
Study of rifampin combo therapy for staph joint infections
This study tests whether adding rifampin to standard antibiotics works better for people with a staph infection in a joint replacement. It aims to find a more effective treatment for this type of infection.
Fuzhou, FujianAges 18–80 - NCT07335627Recruiting
Clindamycin for strep knee or hip infections
This trial looks at whether the antibiotic clindamycin works well for treating joint replacement infections caused by strep bacteria. It may help people who had surgery for an infected artificial joint between 2013 and 2024.
StrasbourgAges 18 years+ - NCT07303101Recruiting
One-stage replacement for candida joint infections
This study looks at whether a single surgery to replace a hip or knee joint is effective for infections caused by Candida fungus. It may help people who need a joint replacement due to this type of infection.
StrasbourgAges 18 years+ - NCT03713528Enrolling by invitationPhase 4
Antibiotic placed in bone to help save an infected knee implant
This trial tests whether putting antibiotics directly inside the bone during surgery can improve outcomes for an infected knee prosthesis when the implant is being kept. It may help more people avoid needing full implant removal and replacement.
San Francisco, CaliforniaAges 18 years+ - NCT06737809Recruiting
Silver-coated hip revision for infection
This trial tests a new silver-coated hip implant for people who need a revision due to a chronic infection around the joint. It may help control the infection while replacing the implant.
BerlinAges 18 years+
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Common questions
- Are there clinical trials for periprosthetic joint infection?
- Yes. Clin2 currently lists 27 recruiting periprosthetic joint infection studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periprosthetic joint infection trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periprosthetic joint infection trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.