Clinical trials
Joint Infection clinical trials
Below are recruiting joint infection clinical trials, each written for real people, not researchers. We’re tracking 46 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06771050RecruitingPhase 4
Antibiotics and surgery for hip and knee joint infections
This trial tests different antibiotic types and durations, plus surgical approaches, for people with a current joint infection in a hip or knee. It aims to find the best way to treat the infection and prevent it from coming back.
Garran, Australian Capital TerritoryAges 18 years+ - NCT05902221RecruitingPhase 3
Rifampicin add-on for knee, hip, or shoulder implant infections
This Phase 3 trial tests whether adding rifampicin improves outcomes for implant infections caused by a specific germ (Cutibacterium acnes) after surgery. If you have such an infection and the germ is susceptible, you may be able to receive a rifampicin-based treatment plan.
AnnecyAges 18 years+ - NCT05159739Enrolling by invitation
Study of family genetic risk for joint implant infections
This study looks at whether certain families have a higher genetic risk for infections around joint implants. It may help researchers understand who is more at risk and how to prevent these infections.
Salt Lake City, UtahAges 18–100 - NCT04724603Recruiting
Review of side effects after phage treatment for bone infections
This study looks back at people who were treated with phage therapy for a bone, joint, or implant infection and later had a side effect. It aims to better understand how safe phage therapy is in real-life use.
LyonAges Any age - NCT06293352Recruiting
Comparing two antibiotic spacers for knee infection
This trial compares two types of antibiotic spacers for people with a long-term knee replacement infection. It tests whether a spacer made entirely of antibiotic cement or one with a metal core works better to treat the infection before a new knee replacement.
Chicago, IllinoisAges 18 years+ - NCT03704766Recruiting
Testing fluid markers to detect pediatric joint infections
This study checks special lab markers in joint fluid to tell septic (infected) arthritis apart from other inflammatory causes in children. It may help clinicians detect infection more accurately and quickly so kids can get the right treatment.
Atlanta, GeorgiaAges Up to 17 years - NCT06172010RecruitingPhase 4
Rifampicin plus antibiotics for staph joint replacement infection
This study tests whether adding the antibiotic rifampicin to standard treatment works better than standard treatment alone for staph infections in hip or knee replacements. The goal is to find a more effective way to clear the infection and avoid more surgeries.
Leiden, Zuid HollansAges 18 years+ - NCT06418048Recruiting
Infectious disease registry and biobank trial
This study collects medical information and optional biological samples (like blood or saliva) from people with an active or suspected infection. The goal is to build a large database that can help researchers better understand infectious diseases and develop new ways to diagnose and treat them.
MilanAges 18 years+ - NCT06827496Recruiting
Starting with oral antibiotics for kids' bone and joint infections
This study tests if starting treatment for uncomplicated bone or joint infections in children with oral (by mouth) antibiotics is effective. It focuses on kids who are not severely ill and do not have certain risk factors, and who can begin oral antibiotics right away or after a short course of IV (intravenous) antibiotics.
Copenhagen ØAges 3 months–17 years - NCT06670885Enrolling by invitation
New DNA test for joint replacement infections
This trial uses advanced molecular methods to better diagnose infections in hip or knee replacement joints. The goal is to find infections more accurately so you can get the right treatment sooner.
Milan, MilanoAges 18 years+ - NCT02801253Recruiting
Study of infections around hip, knee, or shoulder implants
This study follows people who have an infection around a hip, knee, or shoulder implant (prosthesis). It uses standard infection tests (like cultures and blood tests) to confirm the diagnosis and better understand this problem after surgery.
Paris, Île-de-France RegionAges 18 years+ - NCT07599865RecruitingPhase 2
Bubble study for knee infection after joint replacement
This trial tests if a contrast agent used in ultrasound can help surgeons see pockets of infection around knee implants during revision surgery. It may help doctors do a better job cleaning out the infection.
Philadelphia, PennsylvaniaAges 18 years+ - NCT03307109Recruiting
Quality of life study for adults with an infected joint implant
This study looks at how treatment affects quality of life for adults who have an infection around a joint implant. You may be asked to complete questionnaires to understand symptoms and daily well-being.
LyonAges 18 years+ - NCT05000723Recruiting
Follow-up for hip joint infection after joint replacement
This study checks what happens over the long term for people who had an infection around a replaced (prosthetic) hip. It mainly helps doctors understand recovery and long-term outcomes after treatment.
LeuvenAges 18 years+ - NCT04538053RecruitingPhase 4
Simpler antibiotics for uncomplicated bone and joint infections in children
This trial looks at whether a simpler antibiotic plan can work for children with uncomplicated bone or joint infections that start in the community. It may help reduce the need for complicated treatment while still keeping the infection under control.
Kingswood, New South WalesAges 1–18 - NCT07107685Recruiting
Joint replacement infections in critical care patients
This trial looks at infections in hip, knee, or shoulder replacements in people who needed critical care and later passed away. It aims to learn from their medical information to better prevent and treat similar infections.
Paris, FranceAges 18 years+ - NCT06126614RecruitingPhase 3
Infection prevention in joint replacement surgery
This trial tests a way to prevent infections for people getting a hip or knee replacement. It compares different methods to see which works best and may help lower your risk of infection after surgery.
Hamilton, OntarioAges 18 years+ - NCT03482245Recruiting
Study how body clock proteins affect immune responses in infections
This study looks at how your body’s daily “clock” proteins may influence your immune response during certain serious infections requiring hospital care. If you qualify, researchers will compare immune signals during treatment to better understand what could improve care.
St Louis, MissouriAges 18–65 - NCT07214311RecruitingPhase 2/Phase 3
A trial of PLG0206 to prevent knee joint infection after surgery
This trial tests if a new drug called PLG0206 can stop a knee joint infection from coming back after a surgery called DAIR. DAIR cleans the infected area and keeps the artificial knee in place, and this study wants to see if adding PLG0206 helps prevent the infection from returning.
Sarasota, FloridaAges 18–80 - NCT06919913Recruiting
Probiotics for joint infection surgery
This study tests if taking probiotics before and after surgery can help your immune system fight infection in a hip or knee replacement. You would be given a probiotic or a placebo alongside your standard treatment.
New York, New YorkAges 18–90 - NCT06636669Enrolling by invitationPhase 4
Probiotics to prevent repeat joint infection after replacement surgery
This trial tests whether taking probiotics can help prevent another infection in people who have had a hip or knee replacement that became infected. If you are scheduled for revision surgery due to an infection, this study may be a good fit.
Boston, MassachusettsAges 18–90 - NCT04858217Recruiting
Testing blood and joint fluid tests for hip or knee infection
This trial checks how accurate certain blood tests and joint-fluid (synovial) tests are at identifying infections around hip or knee replacements. It also looks at whether these tests are worth the cost, to help doctors choose the best next step.
BolognaAges 18 years+ - NCT05519007Recruiting
Tested no-rinse cleanser to prevent joint infections after surgery
This study compares a no-rinse cleaning solution used during primary joint replacement surgery versus the usual care. It looks at how many people still have a joint infection 90 days after surgery.
Manhasset, New YorkAges Any age - NCT05640336Enrolling by invitation
Antibiotics for early knee or hip joint infections after surgery
This study compares two antibiotic plans for acute (early) infections around an artificial knee or hip, using a procedure to clean the joint and try to keep the implant. It may help find the best approach to control infection and then prevent it from coming back with longer-term antibiotic treatment.
Jacksonville, FloridaAges 18 years+
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Joint Infection trials by city
Studies with a site in or near these metro areas.
Joint Infection trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for joint infection?
- Yes. Clin2 currently lists 46 recruiting joint infection studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a joint infection trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a joint infection trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.