Clinical trials
Placebo clinical trials
Below are recruiting placebo clinical trials, each written for real people, not researchers. We’re tracking 5,245 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05778188RecruitingPhase 2
RLS-0071 for newborns with moderate or severe HIE
This trial studies whether RLS-0071 is safe and can help some newborns with moderate or severe hypoxic-ischemic encephalopathy (HIE), a brain injury caused by low oxygen around birth. Babies in the study also receive standard whole-body cooling (therapeutic hypothermia), and the researchers will watch for side effects and early signs of benefit.
Little Rock, ArkansasAges Up to 10 hours - NCT05778591RecruitingPhase 2
Low-dose buprenorphine to improve social drive in schizophrenia
This study tests whether low-dose buprenorphine can improve social motivation in people with schizophrenia. It compares social motivation changes while keeping participants stable on treatment and avoiding certain medicines and substances.
Los Angeles, CaliforniaAges 18–60 - NCT05778617RecruitingPhase 3
Ambroxol to Slow Parkinson’s Disease Progression
This trial studies whether ambroxol (or a placebo) can slow the progression of Parkinson’s disease. It may help by aiming to change how the disease develops over time.
BirminghamAges 35–75 - NCT05780905RecruitingPhase 4
Semaglutide study for brain blood flow in type 2 diabetes
This trial tests whether semaglutide changes blood flow in the brain and the brain’s “barrier” (how well the brain is protected) in people with type 2 diabetes. It may help researchers understand brain-related effects of diabetes treatment using scans and blood tests.
Seattle, WashingtonAges 40–65 - NCT05781009RecruitingPhase 2
Pregnenolone treatment for alcohol use disorder
This Phase 2 study tests pregnenolone to help reduce or improve alcohol use disorder symptoms. It looks for adults who drink regularly and meet diagnostic criteria for moderate to severe alcohol use disorder, while excluding people with certain other substance use, medicines, or serious mental/medical conditions.
New Haven, ConnecticutAges 18–70 - NCT05782244RecruitingPhase 2
Sildenafil trial for long-term brain blood-flow problems after TBI
This Phase 2 study tests whether sildenafil (a medication better known for erectile function) can improve long-term symptoms and brain blood-flow issues after a past traumatic brain injury (TBI). It may help by improving blood vessel function in the brain and possibly reducing persistent post-concussion symptoms.
Philadelphia, PennsylvaniaAges 18–70 - NCT05785299Recruiting
Testing home vs clinic introduction of milk for babies
This study compares introducing cow’s milk at home versus in a clinic for babies who may have a non-allergy type reaction to cow’s milk. It may help families learn the safest way to reintroduce milk when classic milk allergy tests are negative.
GroningenAges 1 month–1.5 years - NCT05785065RecruitingPhase 2
Mycophenolate for early lung scarring in systemic sclerosis
This Phase 2 study tests whether mycophenolate mofetil (MMF) can slow or improve early, mild lung scarring in people with systemic sclerosis. It’s meant for systemic sclerosis patients who have lung involvement on a CT scan but still have good breathing test results.
Montreal, QuebecAges 18 years+ - NCT05786066RecruitingPhase 2
Test whether blocking AMPA changes ketamine’s suicide relief
This study looks at whether an “AMPA receptor blocker” changes how ketamine affects suicidal thoughts in people with depression that hasn’t improved with usual treatments. If you qualify, you may receive ketamine and the study medicine, while continuing your regular mental health care.
West Haven, ConnecticutAges 21–65 - NCT05786443RecruitingPhase 2
Empagliflozin test in adults on regular dialysis
This study tests whether the medicine empagliflozin is safe and helpful for adults who are on regular hemodialysis and still make a small amount of urine. The goal is to see if it can improve health outcomes while tracking side effects closely.
Boston, MassachusettsAges 18 years+ - NCT05788276RecruitingPhase 4
Dapagliflozin to help transplanted kidneys stay healthy
This study tests whether dapagliflozin can preserve the structure and function of a kidney transplant. You may be asked to take dapagliflozin on top of usual transplant medicines to see if it helps the new kidney work better over time.
Oslo, OsloAges 18–75 - NCT05790356Recruiting
Fecal transplant to treat rheumatoid arthritis symptoms
This study tests whether transferring stool from a screened healthy donor into the gut can improve rheumatoid arthritis (RA) in people whose RA is in remission or low activity. It’s mainly trying to change the gut bacteria to reduce RA symptoms or flare-ups.
London, OntarioAges 18 years+ - NCT05791396RecruitingPhase 1/Phase 2
Fecal microbiome therapy to clear hard-to-treat gut germs
This trial looks at a treatment made from stool donors (called fecal microbiome therapy) to help remove carbapenem-resistant gut bacteria in the body. It’s mainly for adults who recently tested positive for these bacteria on a rectal swab, and it checks whether the therapy can help eradicate the germs.
RomaAges 18–85 - NCT05795465RecruitingPhase 2
Study drug for people with acute respiratory distress syndrome
This Phase 2 trial tests GEn-1124 to see if it can improve outcomes in people with acute respiratory distress syndrome (ARDS). You may be eligible if the study drug can be started very soon after ARDS is diagnosed and if you meet the safety and health requirements.
Washington D.C., District of ColumbiaAges 18–85 - NCT05797831RecruitingPhase 2/Phase 3
Maintenance treatment for TP53-wildtype endometrial cancer
This trial tests navtemadlin as a maintenance (ongoing) treatment to help prevent endometrial cancer from coming back after chemotherapy works. It is mainly for people whose cancer has certain genetic features (TP53 “wildtype”) and who had a strong response to first-line taxane–platinum chemo.
Vallejo, CaliforniaAges 18 years+ - NCT05802264RecruitingPhase 1
Inhaled amphotericin B for healthy volunteers and cystic fibrosis
This early-phase study tests how different doses of an inhaled medicine (amphotericin B) work and are tolerated. It includes healthy adults and people with cystic fibrosis (CF) to see if the dose schedule is safe and potentially beneficial.
Canberra, Australian Capital TerritoryAges 16 years+ - NCT05804084RecruitingPhase 2
Acetazolamide for sleep apnea: sleep and brain outcomes
This study tests acetazolamide (a medicine that changes breathing chemistry) to see how it affects sleep quality and neurocognitive (brain/memory/attention) outcomes in adults with untreated moderate to severe sleep apnea. You may be eligible if you have significant sleep apnea but do not have certain safety risks or need to start standard sleep apnea treatment right away.
La Jolla, CaliforniaAges 18 years+ - NCT05804591RecruitingPhase 4
Pregabalin during weight-loss surgery to reduce pain
This trial tests whether pregabalin can help with pain control for people having laparoscopic sleeve gastrectomy (a weight-loss surgery). It may help reduce the discomfort around surgery and improve the overall recovery experience.
Warsaw, WarsawAges 18 years+ - NCT05805683Recruiting
Calcitonin for nerve pain after spinal cord injury
This study tests whether calcitonin can prevent or lessen nerve pain after a spinal cord injury. It may help reduce how often neuropathic (nerve-type) pain happens and how severe it becomes.
Tanta, Gharbia GovernorateAges 18 years+ - NCT05806346Recruiting
TXA dosing for heart surgery patients on bypass
This trial studies whether giving tranexamic acid (TXA) based on patient needs during heart surgery works better than a one-size-fits-all approach. It may help reduce bleeding during surgery, while monitoring for clotting-related side effects.
SeoulAges 19 years+ - NCT05807139RecruitingPhase 1
Spironolactone for alcohol use disorder
This Phase 1 study tests whether spironolactone (a medicine that affects salt and hormone balance) is safe and potentially helpful in people with alcohol use disorder. You may be eligible if you are currently drinking heavily, have low alcohol withdrawal symptoms, and meet several lab and medication safety rules.
Baltimore, MarylandAges 21–99 - NCT05807867Recruiting
Support program to help women with HIV keep treatment working
This study tests a stigma-reducing support program to help women living with HIV and serious mental illness stay adherent to HIV treatment. It focuses on sustaining viral suppression by addressing stigma that can make care harder, and it involves family and community leaders as part of the approach.
GaboroneAges 18–65 - NCT05814055RecruitingPhase 2
Kava to help quit smoking by easing stress and sleep issues
This Phase 2 study tests whether kava can help people quit smoking, especially by reducing stress and improving sleep during tobacco abstinence. You may be offered kava as part of a quitting support plan and monitored for safety and progress.
Gainesville, FloridaAges 21–75 - NCT05816798RecruitingPhase 2/Phase 3
Laser treatment to reduce chronic knee pain before weight-surgery
This trial tests whether photobiomodulation (a type of laser/light therapy) can reduce chronic pain in both knees for people preparing for bariatric (weight-loss) surgery. If you have knee pain that limits daily life, the treatment may help you feel better while you’re in the pre-surgery rehabilitation period.
Goiânia, GoiásAges 18–70
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Common questions
- Are there clinical trials for placebo?
- Yes. Clin2 currently lists 5,245 recruiting placebo studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a placebo trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a placebo trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.