Clinical trials
Placebo clinical trials
Below are recruiting placebo clinical trials, each written for real people, not researchers. We’re tracking 5,158 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06641466RecruitingPhase 3
Study of Rimegepant for preventing menstrual migraine in women
This study tests whether the medicine rimegepant can help prevent migraines that happen around your period. It is for women with regular menstrual cycles who have a history of menstrual migraines.
Phoenix, ArizonaAges 18–45 - NCT06639464RecruitingPhase 2
Semaglutide for improving opioid recovery outcomes
This study tests whether semaglutide (a medication used for weight management) can help people on buprenorphine or methadone reduce their opioid use. If it works, it could provide additional support during recovery.
Boston, MassachusettsAges 18 years+ - NCT06643221RecruitingEarly Phase 1
Exercise as a booster for cell therapy treatments
This trial tests whether exercise and a heart medicine called isoproterenol can help your immune system work better with donor cell therapies. It may show how to make these treatments more effective.
Tucson, ArizonaAges 21–55 - NCT06639126Enrolling by invitation
Thyme extract for functional gut issues
This trial tests whether a wild thyme extract can help with functional gastrointestinal disorders (common digestive problems without a clear cause). It focuses on the extract's anti-inflammatory and metabolism-related effects.
Granada, GranadaAges 18–75 - NCT06638710RecruitingPhase 2
Testing oral midazolam for care in elderly with dementia who refuse care
This trial tests if giving a medication called midazolam by mouth can help older adults with memory problems who refuse care to accept it more calmly. It is for people in certain hospital or long-term care units, with moderate to severe memory loss and a history of resisting care.
Grenoble, IsereAges 60 years+ - NCT06636786RecruitingPhase 2
Medication to reduce stress symptoms after a car accident
This study tests whether a medication placed under the tongue can help prevent or reduce stress-related symptoms, like anxiety or post-traumatic stress, after a motor vehicle crash. It may help you feel better in the weeks following the accident.
Birmingham, AlabamaAges 18–55 - NCT06639282RecruitingPhase 2
Testing siponimod for mild Alzheimer's dementia
This study tests if a medicine called siponimod, already used for multiple sclerosis, can help people with mild Alzheimer's dementia. You will take a pill daily and be monitored closely for safety and cognitive changes.
Phoenix, ArizonaAges 50–85 - NCT06639984RecruitingPhase 2
Psyllium for kids with IBS
This study tests if psyllium, a fiber supplement, helps reduce belly pain and other symptoms in children with irritable bowel syndrome (IBS). It may be an option if standard treatments haven't worked well.
Durham, North CarolinaAges 12–17 - NCT06635902RecruitingPhase 2
Citrulline for sickle cell pain crisis
This trial tests if an intravenous medication called L-citrulline can help treat pain crises in children and young adults with sickle cell disease. Participants receive either the study drug or a placebo while in the hospital for a severe pain episode.
Washington D.C., District of ColumbiaAges 4–21 - NCT06634056RecruitingPhase 2
Preventing lung inflammation during chemoradiation for stage III lung cancer
This trial tests whether two medicines, pentoxifylline and vitamin E, can help prevent a type of lung inflammation called pneumonitis in people with stage III non-small cell lung cancer who are getting chemoradiation and a checkpoint inhibitor. These medicines are already used for other conditions and may lower the risk of this side effect.
Toronto, OntarioAges 18 years+ - NCT06641271Enrolling by invitation
Vagus nerve stimulation with hand exercises for MS
This study tests if vagus nerve stimulation (a mild electrical pulse on the ear) combined with hand exercises can help repair the protective coating of your nerves and improve hand function in multiple sclerosis.
Aurora, ColoradoAges 18–70 - NCT03646058RecruitingPhase 3
Add-on buprenorphine to ease suicidal thoughts in depression
This Phase 3 study tests whether adding buprenorphine to your usual pain-dose medicines can reduce severe suicidal thoughts during a major depressive episode. It may help people who are currently hospitalized or closely followed and have higher scores for both depression severity and suicidal thinking.
Bordeaux, FranceAges 18–65 - NCT06625073RecruitingPhase 4
SGLT2i for heart transplant recipients
This trial is testing a medication called SGLT2i (a type of diabetes drug that also helps the heart and kidneys) in people who have received a heart transplant. It aims to see if this drug can improve health after transplant.
Palo Alto, CaliforniaAges 18 years+ - NCT05762952RecruitingPhase 1
Dapagliflozin study for heart micro-blood-flow symptoms in women
This early-phase study tests whether dapagliflozin can improve tiny blood-vessel function in women who have heart-ache-like symptoms but no major blockage on heart scans. If it works, it may help symptoms related to “microvascular” heart circulation problems.
Charlottesville, VirginiaAges 18–99 - NCT04959864Recruiting
Food supplement study for sperm DNA damage in men
This trial tests whether a daily food supplement (with myo-inositol, N-acetyl-cysteine, zinc, and vitamins) can reduce sperm DNA damage. It enrolls men with higher-than-normal sperm DNA fragmentation, and it checks semen health during the study.
ParisAges 20–45 - NCT06632379RecruitingPhase 4
Atorvastatin after pregnancy to lower heart risk
This trial tests if taking atorvastatin, a common cholesterol medication, after delivery can reduce future heart problems in women who had high blood pressure or preeclampsia during pregnancy. It lasts for 6 months and includes participants who are at least 20 years old.
Columbus, OhioAges 20–50 - NCT06618820Enrolling by invitationPhase 3
Extended tranexamic acid after knee replacement
This trial tests whether taking tranexamic acid (a medicine that helps blood clot) for several days after knee replacement surgery reduces bleeding and improves recovery. It may help patients who have a standard knee replacement and are not on blood thinners.
Germantown, TennesseeAges 18 years+ - NCT06629259RecruitingPhase 2
Guanfacine for Alcohol Use Disorder
This trial tests if guanfacine, a medication that calms certain brain signals, can help people reduce or stop drinking. You may qualify if you have moderate to severe alcohol use disorder and want to quit.
Indianapolis, IndianaAges 18 years+ - NCT06627868Recruiting
NAD+ metabolism in human brown fat
This study explores how the body's natural substance NAD+ works in brown fat, a type of fat that burns calories. It may help researchers understand metabolism and find new ways to treat obesity.
TurkuAges 30–65 - NCT06620809RecruitingPhase 1
New treatment for neuromyelitis optica flare-ups
This trial tests a new medicine (NouvSoma001) for people with neuromyelitis optica (NMOSD) who are having a flare-up. The goal is to see if the treatment is safe and if it helps reduce symptoms like pain and trouble moving.
Wuhan, HubeiAges 18–65 - NCT06629090RecruitingPhase 2
Brain blood vessel responses to blood flow changes: younger adults
This study looks at how the brain's blood vessels respond to changes in blood flow in healthy younger adults. It helps researchers understand normal brain aging.
Madison, WisconsinAges 20–40 - NCT06626139RecruitingPhase 2
Psilocybin study for healthy volunteers
This trial tests how the setting and context affect the experience of psilocybin, a psychedelic drug. It aims to understand how the environment influences the effects in healthy adults.
San Francisco, CaliforniaAges 21–70 - NCT06629077RecruitingPhase 2
Brain blood vessel response to blood flow changes
This study looks at how blood vessels in the brain react when blood flow changes. It may help researchers understand how the brain adapts with age.
Madison, WisconsinAges 55–69 - NCT06630884RecruitingPhase 1
Immune response to trauma and fear
This study looks at how the body's immune and stress systems work together in people who have experienced trauma, by giving a harmless vaccine to temporarily boost inflammation. It may help explain why some people develop PTSD and others don't, which could lead to better treatments.
San Francisco, CaliforniaAges 18–65
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Common questions
- Are there clinical trials for placebo?
- Yes. Clin2 currently lists 5,158 recruiting placebo studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a placebo trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a placebo trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.