Clinical trials
Chronic Postoperative Pain clinical trials
Below are recruiting chronic postoperative pain clinical trials, each written for real people, not researchers. We’re tracking 306 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07018375RecruitingPhase 4
Oliceridine for reducing chronic pain after lung surgery
This study tests whether a new pain medication (oliceridine) given through an IV patient-controlled pump can reduce chronic pain after lung surgery. Participants will receive either oliceridine or a standard opioid for pain control after a minimally invasive lung resection. The study will follow patients for several months to see if they develop long-term pain.
Baoding, HebeiAges 18–75 - NCT07789301Recruiting
Predicting severe pain after planned cesarean with spinal anesthesia
This study looks at how to predict severe pain after a planned cesarean delivery done under spinal anesthesia. It aims to find factors that may help doctors better manage pain after surgery.
Bursa, NilüferAges 18–45 - NCT07511985Recruiting
Managing Pain After Knee Replacement Surgery
This study looks at how "rebound pain" (increased pain when pain medication wears off) affects long-term pain after total knee replacement. Researchers want to understand this connection and potentially improve pain management strategies for knee surgery patients.
Konya, MeramAges 18 years+ - NCT07341854Recruiting
Dexamethasone shot for pain after surgery
This study tests a special form of dexamethasone (a steroid) given as a shot before surgery to help control pain after the operation. It may reduce the need for other pain medicines and make recovery more comfortable.
Beijing, ChinaAges 18–65 - NCT06878014RecruitingPhase 4
Morphine for pain relief after hip replacement surgery
This trial tests different doses of morphine given during spinal anesthesia to find the safest and most effective way to control pain after hip replacement surgery. If you are having a total hip replacement, you may be able to join.
Sosnowiec, Silesian VoivodeshipAges 18–75 - NCT06696430Recruiting
Nudging to use TENS for pain after surgery
This trial tests whether a simple reminder (nudging) can encourage staff and patients to use a device called TENS, which uses mild electrical pulses to help reduce pain after urological surgery.
Gothenburg, VGRAges 18 years+ - NCT07642596Recruiting
Root Canal Treatment Methods and Post-Procedure Pain
This study compares two different techniques for cleaning and shaping root canals (the nerve chambers inside teeth) to see which one causes less pain after treatment. If you have a dead nerve in a back lower tooth, this trial may help us understand the best way to treat it with minimal discomfort.
Eskişehir, OdunpazarıAges 18–65 - NCT07717151Recruiting
Preventing long-term pain after surgery for chronic opioid users
This trial tests a method to prevent chronic pain after surgery in people who already take opioids regularly. It may help reduce long-term pain and improve recovery.
AmiensAges 18 years+ - NCT03675386Recruiting
Help reducing opioid use after surgery for chronic pain
This trial tests a program to help people with long-term (chronic) pain use less opioid medicine after surgery. It may help you reduce opioid doses while still managing your pain.
Toronto, OntarioAges 18 years+ - NCT04439552Recruiting
MRI study during cornea cross-linking for keratoconus
This trial uses an MRI scan (and a close-up eye scan) to study what happens in the cornea during treatment for keratoconus. It may help doctors better understand how treatment works and who benefits most.
Boston, MassachusettsAges 8–35 - NCT04874038RecruitingPhase 3
Lidocaine infusions to prevent long-lasting pain after breast surgery
This Phase 3 study tests whether receiving lidocaine through an IV during breast surgery can lower the chance of ongoing pain afterward. If it works, it may help some people avoid chronic, surgery-related pain in the chest wall, shoulder, or arm.
Calgary, AlbertaAges 18–100 - NCT05172739RecruitingPhase 4
Opioid-free anesthesia during lung surgery for early lung cancer
This study tests whether an opioid-free pain/anesthesia plan during elective lung surgery can reduce surgical “stress” on the body and affect the immune system. You may be eligible if you have early-stage non-small cell lung cancer and are scheduled for a specific type of surgery (VATS lobectomy).
Heraklion, CreteAges 18–80 - NCT05193227RecruitingPhase 2
Slow-release lidocaine patch for pain after pelvic surgery
This Phase 2 study tests a slow-release form of lidocaine to reduce pain after surgery that uses a pelvic incision. If you’re having a qualifying pelvic operation, the study may help see whether this medication improves postoperative pain control.
Vancouver, British ColumbiaAges 19 years+ - NCT05382962Recruiting
Using an app to help teens cope with post-surgery pain
This trial tests whether a phone app (iCanCope) can help teens better manage pain after surgery for scoliosis or certain chest conditions (pectus carinatum/excavatum). If you’re having one of these surgeries soon, the app may help with coping and day-to-day comfort after the operation.
Boston, MassachusettsAges 12–18 - NCT05404581Recruiting
Insula brain stimulation for long-term nerve pain
This trial tests whether stimulating a specific brain area (the insula) can reduce chronic nerve pain. It is for people whose pain has lasted at least 6 months and has not improved enough with several pain medicines and other procedures.
Charlottesville, VirginiaAges 18–80 - NCT05494502Recruiting
Nerve block to reduce long-term pain after breast surgery
This trial tests whether a specific pain-numbing nerve block given during mastectomy can reduce chronic (long-lasting) pain after breast cancer surgery. It may help some people use less pain medicine later by lowering nerve-related pain after surgery.
Beijing, Beijing MunicipalityAges 18–85 - NCT05795478Recruiting
Oxycodone plus pregabalin for long-term pain after spinal surgery
This trial studies whether taking oxycodone together with pregabalin (both pain medicines) can reduce chronic pain that can linger after spinal surgery. If you qualify, you may be asked to rate your pain and complete questionnaires during recovery.
BeijingAges 18 years+ - NCT05877157Recruiting
Study how pain and opioids change after surgery
This study follows adults in the hospital after surgery to understand how pain and opioid (strong pain medicine) use affect them. Your answers on questionnaires help researchers see what happens after different types of anesthesia.
Zagreb, Vinogradska 29Ages 18 years+ - NCT05917262Recruiting
Mindfulness breathing vs heart-rate training after shoulder surgery pain
This trial compares two non-drug techniques—mindful breathing and heart-rate (HR) biofeedback—to see which helps reduce pain after shoulder surgery. You may be able to join if you have ongoing shoulder pain after surgery and haven’t been using these practices very often.
TaoyuanAges 18 years+ - NCT06023225Recruiting
Sex hormones, pain, and opioid use in girls after surgery
This study looks at how sex hormones affect pain and the use of pain medicine after orthopedic surgery in girls. It might help explain why some people need more pain relief than others.
St Louis, MissouriAges 11–16 - NCT06083480RecruitingPhase 4
Reducing stress to prevent long-term pain after knee replacement
This trial tests if lowering oxidative stress (damage from natural body processes) during knee replacement surgery can prevent chronic pain afterward. It may help people with osteoarthritis who have moderate to severe pain before surgery.
Nashville, TennesseeAges 50 years+ - NCT06094257Recruiting
Study on sensation and satisfaction after mastectomy
This study looks at how people feel after mastectomy, including transgender patients and those having nipple-sparing surgery. It aims to understand sensation and satisfaction to improve future care.
Boston, MassachusettsAges 18 years+ - NCT06222151Recruiting
Recovering from weight-loss surgery with early walking
This study tests whether starting a supervised walking program soon after weight-loss surgery helps you recover faster. It aims to see if early movement improves your recovery and hospital stay.
Esbjerg, Region SyddanmarkAges 18–70 - NCT06281431Recruiting
Study comparing two needle types for nerve blocks to reduce pain
This trial compares a special echogenic (ultrasound-visible) needle with a standard needle for nerve blocks during surgery. The goal is to see which works better for preventing both short-term and long-term pain after operations like chest, abdomen, or limb surgeries.
Chongqing, Chongqing MunicipalityAges 18–70
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Common questions
- Are there clinical trials for chronic postoperative pain?
- Yes. Clin2 currently lists 306 recruiting chronic postoperative pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic postoperative pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic postoperative pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Postoperative Pain
- Postoperative Pain, Acute
- Postoperative Pain Management
- Total Knee Arthroplasty (Postoperative Pain)
- POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
- Postoperative Pain After Endodontic Treatment
- Postoperative Pain Following Knee Arthroplasty
- Postoperative Pain Management in Oral Surgery
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.