Clinical trials
Postsurgical Pain clinical trials
Below are recruiting postsurgical pain clinical trials, each written for real people, not researchers. We’re tracking 23 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06574269RecruitingPhase 2
Study on TLC590 for pain after surgery
This trial tests a new pain medicine, TLC590, for people having one of several common surgeries, like bunion removal, hernia repair, breast augmentation, knee replacement, or tummy tuck. The goal is to see if it helps manage pain after the procedure.
Bellaire, TexasAges 18–70 - NCT05324254Recruiting
Weighted blankets to help after breast surgery pain
This study tests whether sleeping with a weighted blanket can reduce pain after breast surgery. You may use a smartphone app to quickly report how your pain and comfort feel over time for up to 3 months.
La Jolla, CaliforniaAges 18 years+ - NCT05369130Recruiting
Predict pain after major aortic surgery
This study tries to understand and predict persistent pain after elective surgery on the thoraco-abdominal aorta (a major blood vessel in the chest and belly). The goal is to learn what factors may help patients have less long-lasting pain after surgery.
LondonAges 18 years+ - NCT07717151Recruiting
Preventing long-term pain after surgery for chronic opioid users
This trial tests a method to prevent chronic pain after surgery in people who already take opioids regularly. It may help reduce long-term pain and improve recovery.
AmiensAges 18 years+ - NCT05193227RecruitingPhase 2
Slow-release lidocaine patch for pain after pelvic surgery
This Phase 2 study tests a slow-release form of lidocaine to reduce pain after surgery that uses a pelvic incision. If you’re having a qualifying pelvic operation, the study may help see whether this medication improves postoperative pain control.
Vancouver, British ColumbiaAges 19 years+ - NCT06555107Recruiting
Pain before emergency surgery and long-term pain after
This study looks at whether pain you feel before emergency surgery affects long-term pain after the surgery. It may help doctors find ways to prevent chronic pain in patients who have emergency orthopedic (bone/joint) or abdominal (belly) surgery.
AmiensAges 18 years+ - NCT05407610Recruiting
Compare two types of nerve pain treatments for knee pain
This study compares conventional versus cooled radiofrequency treatments for long-lasting knee pain. It aims to see which method reduces pain better and helps patients function more comfortably.
AntwerpAges 18 years+ - NCT07511985Recruiting
Managing Pain After Knee Replacement Surgery
This study looks at how "rebound pain" (increased pain when pain medication wears off) affects long-term pain after total knee replacement. Researchers want to understand this connection and potentially improve pain management strategies for knee surgery patients.
Konya, MeramAges 18 years+ - NCT05196503RecruitingPhase 3
PRF gel in spine surgery to reduce nerve pain after herniation
This Phase 3 study tests whether applying a healing material called platelet-rich fibrin (PRF) around the nerve during disc herniation surgery can reduce leftover nerve pain afterward. If you qualify, your team will compare pain intensity between standard care and PRF during the operation.
Strasbourg, Bas-RhinAges 18 years+ - NCT06344169RecruitingPhase 2/Phase 3
Pain relief after C-section with Naldebain
This trial tests a long-acting painkiller, Naldebain, for women having a planned C-section. It aims to see if it provides better pain control after the surgery.
Dalin, Chai-YiAges 20 years+ - NCT05764681Recruiting
Study for long-term pain after surgery
This study is for people who have chronic post-surgical pain and have a planned surgery on a leg or the spine. The goal is to better understand this long-term pain and what may help manage it after surgery.
Wilmington, DelawareAges 5–17 - NCT05795478Recruiting
Oxycodone plus pregabalin for long-term pain after spinal surgery
This trial studies whether taking oxycodone together with pregabalin (both pain medicines) can reduce chronic pain that can linger after spinal surgery. If you qualify, you may be asked to rate your pain and complete questionnaires during recovery.
BeijingAges 18 years+ - NCT07018375Enrolling by invitationPhase 4
Oliceridine for pain after lung surgery
This trial tests a pain medicine called oliceridine, given through a pump you control after lung surgery, to see if it helps prevent long-term pain. It is for people having a VATS procedure to remove part of their lung and who are generally healthy.
TianjinAges 18–75 - NCT06946290Recruiting
Nerve block for pain relief after heart surgery
This study tests a nerve block, called an intertransverse process block, to see if it helps people feel better and recover faster after heart surgery. The block is given during surgery to reduce pain.
Hong KongAges 18 years+ - NCT05816174Recruiting
Study of long-term pain after bone surgery in children
This study follows children and teens to learn how pain can last after planned orthopedic (bone) surgery in the hospital. It may help doctors better understand which kids are more likely to have long-lasting pain and how to support them.
BaselAges 8–18 - NCT06083480RecruitingPhase 4
Reducing stress to prevent long-term pain after knee replacement
This trial tests if lowering oxidative stress (damage from natural body processes) during knee replacement surgery can prevent chronic pain afterward. It may help people with osteoarthritis who have moderate to severe pain before surgery.
Nashville, TennesseeAges 50 years+ - NCT05494502Recruiting
Nerve block to reduce long-term pain after breast surgery
This trial tests whether a specific pain-numbing nerve block given during mastectomy can reduce chronic (long-lasting) pain after breast cancer surgery. It may help some people use less pain medicine later by lowering nerve-related pain after surgery.
Beijing, Beijing MunicipalityAges 18–85 - NCT07693270Recruiting
Study looking for markers of pain and opioid response after injury or surgery
This study is looking for biological markers (like blood tests) that can predict how people will respond to pain and opioids after a traumatic injury or surgery. The goal is to help doctors tailor pain treatment to each person.
La Jolla, CaliforniaAges 18 years+ - NCT07185594RecruitingPhase 2/Phase 3
Study of a new pain drug after abdominal surgery
This trial tests a new medication called HRS-2129 for managing pain after abdominal surgery. It is for adults who will have moderate to severe pain after their operation, and aims to see if the drug can help control that pain safely.
Zhengzhou, HenanAges 18 years+ - NCT06087510RecruitingPhase 4
Different doses of esketamine and dexmedetomidine for pain after scoliosis surgery
This trial tests two different doses of esketamine and dexmedetomidine to see which provides better pain relief after scoliosis correction surgery. It aims to improve your recovery and long-term outcomes.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06731985Recruiting
Shorter sling tape follow-up study
This study looks at how well and how safely a shorter type of sling tape (used to treat stress urinary incontinence) works over time. It may help women who had this specific surgery between 2009 and 2020 understand their long-term results.
LorenskogAges 25–90 - NCT05050409Recruiting
Program to help recovery after knee replacement surgery
This trial tests a supportive, coach-like “embedded” program designed to help you stay engaged and ready for recovery after one knee replacement. It may be helpful if you want extra support before and after surgery to follow through with your recovery plan.
Fort Sam Houston, TexasAges 18 years+ - NCT07311889Enrolling by invitation
Patient satisfaction with ELIXIR MD during plastic surgery recovery
This study looks at how satisfied patients are with their recovery after plastic surgery when the ELIXIR MD device is used. It aims to understand if this device helps improve the recovery experience.
Irvine, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for postsurgical pain?
- Yes. Clin2 currently lists 23 recruiting postsurgical pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a postsurgical pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a postsurgical pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.