Clinical trials · Columbus, OH
Pregnancy, High Risk clinical trials in Columbus
We’re tracking 16 recruiting pregnancy, high risk studies with a site in or near Columbus — including Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Columbus
- NCT04836390Enrolling by invitationPhase 2
Donor immune cell treatment after transplant for high-risk AML
This trial tests an additional immune therapy made from donor natural killer (NK) cells given around the time of a special stem cell transplant for children and young adults with high-risk acute myeloid leukemia (AML). It aims to help prevent the leukemia from coming back or not responding after transplant.
Columbus, OhioAges birth–25 years - NCT06050252RecruitingPhase 2
Durvalumab plus chemo before surgery for high-risk bile duct cancer
This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy (gemcitabine and cisplatin) before surgery helps people with a high-risk type of bile duct cancer live longer. If you qualify, you would receive the drug combination before your planned surgery.
Columbus, OhioAges 18 years+ - NCT06172296RecruitingPhase 3
Dinutuximab plus transplant for high-risk neuroblastoma
This trial tests adding a targeted drug called dinutuximab to standard chemotherapy, surgery, and a stem cell transplant for children and young adults with a new diagnosis of high-risk neuroblastoma. The goal is to see if this combination helps more patients stay in remission.
Columbus, OhioAges Up to 30 years - NCT04269902RecruitingPhase 3
Early treatment check for high-risk CLL/SLL
This Phase 3 trial studies an early treatment approach for people with high-risk CLL or SLL who have not yet needed standard therapy. It aims to see if treating earlier can improve outcomes while keeping side effects manageable.
Columbus, OhioAges 18 years+ - NCT05662462Recruiting
Phone coaching to keep blood sugar in range during pregnancy
This study tests whether technology plus coaching can help pregnant people with type 2 diabetes keep their blood sugar in a healthy target range. You may use a smartphone app and, if assigned to that group, a device that tracks glucose continuously.
Columbus, OhioAges 18 years+ - NCT03959085RecruitingPhase 3
Inotuzumab plus chemotherapy for high-risk childhood leukemia
This Phase 3 trial tests whether adding inotuzumab to standard post-induction chemotherapy improves outcomes for children and young teens with high-risk B-ALL, mixed phenotype acute leukemia (MPAL), or certain high-risk B-LLy. It may help by targeting leukemia cells more directly, but participation depends on specific age, lab results, and medical history rules.
Columbus, OhioAges 12 months–25 years - NCT07293715RecruitingPhase 4
Comparing glucose management during labor in type 1 diabetes
This trial looks at two ways to manage blood sugar levels during labor in pregnant people with type 1 diabetes. It aims to find the safest approach for both the patient and the baby.
Columbus, OhioAges 18 years+ - NCT06445946RecruitingPhase 4
Metformin vs insulin for gestational diabetes
This study compares two common medicines (metformin pills and insulin shots) to see which works better for controlling blood sugar in pregnant women with gestational diabetes. The goal is to find the best treatment for both mom and baby, now and in the long term.
Columbus, OhioAges 18 years+ - NCT07560813Recruiting
Nutrition and food support for pregnant people with diabetes
This study helps pregnant people with type 1 or type 2 diabetes who struggle to afford healthy food. You'll receive nutrition counseling and access to fresh food through a local program to help manage your blood sugar and have a healthier pregnancy.
Columbus, OhioAges 18 years+ - NCT06396078RecruitingPhase 4
Antibiotics for Early Water Breaking Before Delivery
This study tests whether giving antibiotics to pregnant people with early water breaking (PPROM) before delivery improves outcomes. It aims to prevent infections and protect both parent and baby while waiting for delivery.
Columbus, OhioAges 18 years+ - NCT05909046Recruiting
Diabetes screening after childbirth and follow-up care study
This study checks how well diabetes screening done right after delivery works, and then offers follow-up care for participants later after birth. It may help you catch ongoing diabetes risk early and connect you to the right care.
Columbus, OhioAges 18 years+ - NCT05941520RecruitingPhase 2
Acolbifene vs low-dose tamoxifen to prevent breast cancer
This Phase 2 trial compares acolbifene and low-dose tamoxifen to see which better lowers breast cancer risk in premenopausal women at high risk. You would be followed with health visits, blood tests, and a breast tissue sampling procedure.
Columbus, OhioAges 35 years+ - NCT04031677RecruitingPhase 3
Surgery with or without chemotherapy for high-risk retroperitoneal sarcoma
This trial studies whether adding chemotherapy before surgery helps people with high-risk retroperitoneal (abdominal-area) leiomyosarcoma or liposarcoma. The goal is to improve outcomes while comparing surgery alone versus surgery plus neoadjuvant chemotherapy.
Columbus, OhioAges 18 years+ - NCT03937635RecruitingPhase 3
Lenalidomide and dexamethasone, with or without daratumumab
This phase 3 trial studies whether lenalidomide plus dexamethasone can prevent or delay progression of “high-risk smoldering” multiple myeloma, and whether adding daratumumab improves outcomes. It’s meant for people who are not yet showing symptoms, but whose lab and scan results suggest higher risk.
Columbus, OhioAges 18 years+ - NCT05040360RecruitingPhase 2
Chemotherapy after surgery for high-risk pancreatic NET tumors
This Phase 2 trial studies whether giving chemotherapy after surgery can lower cancer recurrence risk in people with high-risk pancreatic neuroendocrine tumors (NETs). It may help you by testing an added treatment after the tumor has been removed.
Columbus, OhioAges 18 years+ - NCT04752722RecruitingPhase 1/Phase 2
Gene therapy for bladder cancer that came back after BCG
This study tests a new gene therapy (EG-70) given directly into the bladder for people with a high-risk bladder cancer called NMIBC. It may be an option if BCG treatment stopped working, or if you cannot have or choose not to have bladder removal surgery.
Gahanna, OhioAges 18 years+
Hear when a new Pregnancy, High Risk trial opens near Columbus, OH
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Pregnancy, High Risk trials in other cities
Where these studies are running near Columbus
Institutions with a site for the recruiting pregnancy, high risk studies listed above.
- The Ohio State University Wexner Medical Center · 11 studies
- Nationwide Children's Hospital · 3 studies
- Adena Regional Medical Center · 2 studies
- Central Ohio Breast and Endocrine Surgery · 2 studies
- Columbus Oncology and Hematology Associates Inc · 2 studies
- Doctors Hospital · 2 studies
- Dublin Methodist Hospital · 2 studies
- Fairfield Medical Center · 2 studies
What taking part in a pregnancy, high risk study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting pregnancy, high risk studies in Ohio.
Common questions
- Are there pregnancy, high risk clinical trials near Columbus?
- Yes. We're currently tracking 16 recruiting pregnancy, high risk studies with a site near Columbus, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a pregnancy, high risk study near Columbus?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Columbus to take part?
- Not necessarily. These studies have a site near Columbus, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a pregnancy, high risk trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New pregnancy, high risk studies open near Columbus regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.