Clinical trials
Preoperative clinical trials
Below are recruiting preoperative clinical trials, each written for real people, not researchers. We’re tracking 376 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06489327Recruiting
Melatonin before surgery for children
This trial tests two different doses of oral melatonin (a natural sleep hormone) given to children before surgery to help them relax. It may help your child feel calmer before their procedure.
Cairo, Cairo GovernorateAges 4–10 - NCT06461650Recruiting
Nicotine Cessation Before Breast Reconstruction
This study tests whether a program to help women with breast cancer quit using nicotine before reconstructive surgery is feasible and helpful. If you use nicotine and are scheduled for reconstruction, you may be able to join.
Gainesville, FloridaAges 18–80 - NCT06461559RecruitingPhase 1/Phase 2
Bowel training before ileostomy reversal
This study tests whether infusing liquid into the bowel through the stoma before surgery can help prepare the gut. It is for people with a loop ileostomy who are planning to have it reversed.
La Jolla, CaliforniaAges 18–80 - NCT06432972Recruiting
Pre-surgery exercise and smoking cessation program for lung cancer
This trial tests a short, intensive exercise program (pulmonary rehab) before lung cancer surgery. It also helps people quit smoking during the program. The goal is to see if this approach improves recovery after surgery.
Burlington, VermontAges 18 years+ - NCT06379425RecruitingPhase 4
Can pain meds without opioids help you pee sooner after surgery?
This study looks at whether giving a mix of pain medicines (without opioids) before surgery can help you recover faster and avoid needing a catheter after a vaginal repair or sling procedure. It enrolls women having minor gynecologic surgery at the South Shore Surgery Center in New York.
Bay Shore, New YorkAges Any age - NCT05184582Recruiting
Exercise program during chemotherapy for breast cancer
This trial studies whether a structured exercise program during pre-surgery chemotherapy can be safely done and may help people feel and function better during treatment. You may join if you have invasive breast cancer and can commit to the exercise plan while on chemotherapy.
MelbourneAges 18–100 - NCT06349590RecruitingPhase 1/Phase 2
Diet before colon cancer surgery to reduce recurrence
This trial tests whether a specific diet before colon cancer surgery can change the bacteria in your gut to help prevent the cancer from coming back or spreading. Patients who are eligible will follow the diet for a short time before their operation.
Chicago, IllinoisAges 18 years+ - NCT06335862Enrolling by invitation
Surgery to stop windpipe collapse in babies with esophageal atresia
This trial tests a surgery called posterior tracheopexy to prevent the windpipe from collapsing in babies with esophageal atresia and tracheomalacia. It may help your child breathe more easily.
RotterdamAges 8 months+ - NCT06215326Recruiting
Short-term exercise before lung cancer surgery
This trial tests if doing exercise before lung cancer surgery can help people with moderate-to-high risk. Participants will exercise for a short period to see if it improves their recovery.
Guangzhou, GuangdongAges 18 years+ - NCT06015711Recruiting
Does a pre-surgery painkiller reduce strong IV pain meds needed?
This trial tests if taking Maxigesic® (a combination of two pain relievers) before surgery can lower the amount of a strong IV pain medicine called remifentanil needed during anesthesia. It may help patients have a smoother recovery with fewer side effects.
Suwon, Gyeonggi-doAges 19–60 - NCT06184724Recruiting
Pre-surgery check for older adults
This trial tests whether a comprehensive geriatric assessment before major surgery helps older adults. It looks at how well clinics can offer this check to patients 80 or older.
Madison, WisconsinAges 18 years+ - NCT06147024Recruiting
Using 3D printed models to plan aneurysm surgery
This study uses a 3D printed model of your artery bulge (aneurysm) to help your surgeon plan the operation before surgery. It may help make the surgery safer and more personalized.
New Taipei CityAges 18–80 - NCT06144177RecruitingPhase 4
Induction in the dark for kids having surgery
This trial tests whether having general anesthesia in a dark room (instead of a bright one) helps young children feel calmer. It aims to reduce fear and improve the experience for kids ages 2 to 6.
Charleston, South CarolinaAges 2–6 - NCT06133933Enrolling by invitation
Shoulder replacement and pain medication study
This study looks at how your pain tolerance before a total shoulder replacement might relate to how much pain medication you need after surgery. The goal is to help doctors better manage pain medication after surgery.
Camden, New JerseyAges 18 years+ - NCT06136611Recruiting
Pre-surgery Optune for glioblastoma
This trial tests whether wearing a device called Optune (which uses electric fields to slow cancer growth) before surgery helps people with glioblastoma. It is for patients who are fairly active and plan to have standard tumor removal and radiation therapy afterward.
ManchesterAges 35 years+ - NCT06105866Enrolling by invitation
How preoperative fasting affects heart function
This study looks at how the heart's right chamber works in patients who have fasted before surgery. Researchers use an ultrasound test to measure a specific heart function and want to see if not drinking fluids or taking sedatives before surgery changes it.
Aydin, ZaferAges 18–75 - NCT06087861RecruitingPhase 2
Short course radiation before sarcoma surgery
This trial tests a shorter course of radiation (just 5 days) before surgery for soft tissue sarcoma. The goal is to see if a brief, high-dose radiation schedule works as well as or better than the usual longer course—and may be more convenient for you.
Palo Alto, CaliforniaAges 18 years+ - NCT06078709RecruitingPhase 2
Pre-surgery radiation and chemo for esophageal cancer
This trial tests a shorter course of radiation combined with chemotherapy (FOLFOX) before surgery for esophageal or stomach-junction cancer. It aims to reduce side effects and still improve outcomes.
Scottsdale, ArizonaAges 18 years+ - NCT06037980RecruitingPhase 2/Phase 3
Chemotherapy before surgery for high-risk bile duct cancer
This trial tests whether receiving chemotherapy (cisplatin, gemcitabine, and nab-paclitaxel) before surgery can improve outcomes for people with high-risk bile duct or gallbladder cancer. It compares this approach to going straight to surgery.
AnconaAges 18–75 - NCT05748145RecruitingPhase 2
Metronidazole before colon cancer surgery to reduce recurrence risk
This Phase 2 study tests whether taking metronidazole, an antibiotic, before surgery for colorectal cancer can improve outcomes. Participants take it before their planned operation, and doctors study the cancer tissue and related markers to see if it helps.
Bellinzona, Canton TicinoAges 18 years+ - NCT05924178Recruiting
Pre-surgery rehab to improve healing after knee ligament injury
This study looks at whether doing physical therapy before surgery can improve tendon healing, bone density, and joint cushioning after ACL surgery or patellar dislocation surgery. It may help you recover better and faster by optimizing your knee before the operation.
BeijingAges 18–45 - NCT05884723Recruiting
Ketogenic diet before liver surgery for fatty liver
This trial tests whether a ketogenic (very low-carb) diet before liver surgery can reduce fat in the liver. It is aimed at people with colorectal liver metastases who already have fatty liver seen on scans or biopsy.
London, OntarioAges 18 years+ - NCT05848310Recruiting
Blood test before surgery to predict biliary atresia outcome
This study looks at a specific pre-surgery blood marker called FGF19 (and related liver blood tests) in children with biliary atresia. The goal is to see whether the blood results before surgery can help predict how well children recover after surgery.
Shanghai, Shanghai MunicipalityAges Any age - NCT05752136RecruitingPhase 3
Pre-surgery radiation plus immunotherapy and chemo for rectal cancer
This trial tests whether a short course of radiation before surgery, combined with the immunotherapy drug envafolimab and the chemo regimen CAPEOX, works better for shrinking locally advanced rectal cancer. It is aimed at people whose tumor is not “MMR-deficient” (it is pMMR/MSS), and it asks participants to be able to return for repeated checkups and treatments.
Hangzhou, ZhejiangAges 18 years+
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Common questions
- Are there clinical trials for preoperative?
- Yes. Clin2 currently lists 376 recruiting preoperative studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a preoperative trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a preoperative trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.