Clinical trials
Primary Breast Cancer clinical trials
Below are recruiting primary breast cancer clinical trials, each written for real people, not researchers. We’re tracking 715 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06450873RecruitingPhase 2
Turkey tail mushroom before breast cancer surgery
This trial tests whether taking a turkey tail mushroom supplement before breast cancer surgery can help the immune system fight the cancer. It is for post-menopausal women with a common type of breast cancer (ER-positive, HER2-negative) that is growing at a moderate or faster rate (Ki-67 score of 10% or more).
Scottsdale, ArizonaAges 18 years+ - NCT07540572RecruitingPhase 1
Testing IDE574 safety and effectiveness in advanced solid tumors
This early-stage trial tests a new drug called IDE574 to see if it is safe and effective in treating advanced cancers that have spread or stopped responding to standard treatments. The trial focuses mainly on hormone-receptor positive breast cancer, but also includes lung, prostate, and colorectal cancers.
Plantation, FloridaAges 18–99 - NCT06081244RecruitingPhase 3
Testing sacituzumab govitecan with or without pembrolizumab for early triple-negative breast cancer
This trial tests a two-drug combination (sacituzumab govitecan and pembrolizumab) versus sacituzumab govitecan alone before surgery for low-risk, triple-negative breast cancer that hasn't spread. The goal is to see which approach works better at shrinking tumors.
Baden-Baden, Baden-WurttembergAges 18 years+ - NCT04824027Recruiting
Breast ultrasound testing during chemotherapy for breast cancer
This study looks at how breast tissue changes during chemotherapy given before surgery (neoadjuvant therapy). It may help doctors better understand treatment effects by taking special breast measurements.
New York, New YorkAges 18 years+ - NCT05416164Recruiting
Testes less radiation after a complete response to medicines
This study checks whether some people with breast cancer who have no remaining cancer after medicine (neoadjuvant systemic therapy) can safely receive less radiation. It may help reduce side effects while still keeping cancer controlled.
Amsterdam, North HollandAges 18 years+ - NCT07113613RecruitingPhase 2
Can some breast cancer patients skip extra radiation after surgery?
This trial tests whether women who have a complete response to chemotherapy before breast-conserving surgery can safely skip a special radiation boost to the tumor bed. It aims to reduce unnecessary treatment side effects while maintaining good outcomes.
Nanjing, JiangsuAges 30–75 - NCT05535413RecruitingPhase 1/Phase 2
UTD1 plus capecitabine for HER2-negative breast cancer brain mets
This trial tests whether adding a study drug called UTD1 to capecitabine can shrink or control breast cancer that has spread to the brain. It’s for people with HER2-negative metastatic breast cancer who have brain metastases and meet specific safety and lab requirements.
ChangshaAges 18–70 - NCT06137833Recruiting
Micronutrient supplement for severe tiredness in breast cancer chemo
This study tests whether a specially designed vitamin and mineral supplement can help reduce severe tiredness in women while they are receiving chemotherapy for breast cancer. If you are currently in treatment and have bothersome fatigue, this trial may offer a way to feel better.
Brescia, BRESCIAAges 18 years+ - NCT04356235Recruiting
Comparing immediate vs delayed breast implant reconstruction results
This study compares two timing options for rebuilding the breast with implants, looking at cosmetic results, quality of life, and patient satisfaction. It may help you understand which approach could fit you better and what to expect over follow-up time.
BudapestAges 18–65 - NCT06694181Recruiting
Safe and explainable AI for heart, sepsis, and breast cancer patients
This trial uses artificial intelligence (AI) to create prediction models for three groups: cardiology patients, sepsis patients, and breast cancer patients. It aims to make these models safe and easy to understand for doctors.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05450016Recruiting
Using photos and a computer to assess breast appearance after treatment
This study uses a computer (deep neural network) to judge how the breast looks after breast-conserving surgery or full breast reconstruction and radiation therapy. It may help doctors measure cosmetic results more consistently using photographs.
Mumbai, MaharashtraAges 19–80 - NCT02637934RecruitingPhase 1
PET scan tracer study for ovarian or related cancers
This early study tests a radioactive tracer (given as an injection) and tracks how it moves through the body using PET/CT scans. It may help doctors better understand how this tracer behaves in cancers of the ovaries, fallopian tubes, or the lining of the abdomen.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06214195RecruitingPhase 3
Shengmai San to prevent heart damage from breast cancer therapy
This trial tests if a traditional Chinese medicine called Shengmai San can protect the heart during chemotherapy and targeted therapy for HER2-positive breast cancer. Patients take the supplement alongside standard treatment to see if it reduces the risk of heart problems.
Hangzhou, ZhejiangAges 18 years+ - NCT05325632RecruitingPhase 2
HER2 breast cancer vaccine plus chemo and targeted antibodies
This Phase 2 study tests a personalized immune-therapy vaccine made from your immune cells, given with weekly paclitaxel and HER2-targeted antibodies (trastuzumab and pertuzumab). It aims to improve treatment outcomes for people with HER2-positive breast cancer before standard local treatment (like surgery and radiation).
Tampa, FloridaAges 18 years+ - NCT07586319Enrolling by invitation
Surgery to improve survival in early-stage spread breast cancer
This study tests whether surgery to remove cancer spots can help people with breast cancer that has spread to a few places live longer. You would receive standard cancer medicines plus surgery if you qualify.
Lahore, Punjab ProvinceAges 18 years+ - NCT05111561RecruitingPhase 1
Testing a two-drug combo for RAS-mutant or triple negative breast cancer
This study tests a combination of two new drugs, ZEN003694 and binimetinib, for people with advanced solid tumors that have certain gene changes (like RAS mutations) or triple negative breast cancer. The goal is to see if this combination can shrink tumors or slow their growth.
Boston, MassachusettsAges 18 years+ - NCT04475640Recruiting
Genetic testing study for cancer patients in different ethnic groups
This study looks at cancer-related inherited gene changes using blood samples. It may help patients and doctors understand cancer risk and guide treatment planning, especially across different ethnic communities.
Scottsdale, ArizonaAges 18 years+ - NCT07256769Recruiting
Vitamin K, D-chiro inositol and α-lactalbumin for bone health
This trial tests a combination of vitamin K, D-chiro inositol, and α-lactalbumin to help maintain bone strength in women with breast cancer who are on hormone therapy and have low vitamin D. It aims to see if these supplements improve bone health while you take a standard bone medication (alendronate).
Latina, ItalyAges 35–70 - NCT06817525RecruitingPhase 2
Chemo and immunotherapy before surgery for early triple-negative breast cancer
This trial tests whether a combination of chemotherapy drugs (nab-paclitaxel and carboplatin) plus an immunotherapy drug (PD1 inhibitor) given before surgery can help treat early-stage triple-negative breast cancer. It aims to improve outcomes by using these treatments before the main surgery.
Zhengzhou, HenanAges 18–65 - NCT05232916RecruitingPhase 3
Vaccine for HER2-positive breast cancer after standard treatment
This trial tests a vaccine (GLSI-100) that may help prevent the return of HER2-positive breast cancer. It is given to patients who still had cancer cells after initial treatment with trastuzumab, or who had stage III disease and achieved a complete response.
Mobile, AlabamaAges 18–100 - NCT05464082RecruitingPhase 2
Collect tumor samples to guide early breast cancer recurrence care
This Phase 2 study tests a “precision” approach using tumor sample testing to help predict, prevent, and treat early metastatic recurrence in triple-negative or hormone-receptor–low, HER2-negative breast cancer. If you qualify, you’ll be asked to provide tumor tissue before (or in place of) standard chemotherapy, so researchers can learn which tumor features matter most.
Salt Lake City, UtahAges 18 years+ - NCT04819243RecruitingPhase 2
Test a BRCA-targeted drug plan for advanced ER-positive breast cancer
This Phase 2 study tests how well a treatment plan using palbociclib followed by talazoparib (and possibly atezolizumab) works in certain people with advanced ER-positive breast cancer. It may help by targeting cancer biology linked to BRCA/HRD changes and by strengthening how the cancer is controlled.
Seoul, Gannam-guAges 19 years+ - NCT07586215Recruiting
HER2-targeted PET imaging to predict treatment response in advanced breast cancer
This trial tests whether a special type of PET scan can predict how well a targeted cancer drug (T-DXd) will work for patients with advanced breast cancer that has specific HER2 markers. The goal is to help doctors personalize treatment decisions based on imaging results.
ShanghaiAges 18 years+ - NCT06966141Recruiting
Real-World Study of Sacituzumab Govitecan for Breast Cancer
This study looks at how well the drug Sacituzumab Govitecan works in real-life settings for people with certain types of advanced breast cancer that have not responded to prior treatments.
Shanghai, Shanghai MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for primary breast cancer?
- Yes. Clin2 currently lists 715 recruiting primary breast cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a primary breast cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a primary breast cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.