Clinical trials
Probiotic clinical trials
Below are recruiting probiotic clinical trials, each written for real people, not researchers. We’re tracking 224 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07624409Enrolling by invitationEarly Phase 1
Occupational health study for high-altitude workers
This study examines how working at high altitudes (where there is less oxygen in the air) affects employees at an astronomical observatory in Chile. Researchers want to understand health impacts and develop better support for people working in these extreme conditions.
San Pedro de Atacama, AntofagastaAges 20–50 - NCT07585474Enrolling by invitation
Gut Health During Long Travel for Football Players
This study looks at how long airplane trips affect the gut bacteria in professional male football players. Researchers will track changes in your digestive system during pre-season travel to understand if travel impacts your gut health.
Nashville, TennesseeAges 18–40 - NCT06347770RecruitingPhase 1
Oral Gan Shuangbi for recovery after C-section
This trial tests an oral herbal medicine (Gan Shuangbi) to see if it helps your intestines work normally again after a C-section. It may speed up recovery after delivery.
Guangzhou, GuangdongAges 18–45 - NCT07219498Recruiting
Probiotics for muscle soreness after exercise
This trial tests whether taking a probiotic supplement for 5 weeks can reduce muscle soreness after exercise. If you exercise regularly and are generally healthy, you may be able to join.
Minneapolis, MinnesotaAges 18–30 - NCT07167342RecruitingPhase 4
Can a probiotic prevent polyp regrowth after colonoscopy?
This trial tests whether taking a probiotic called Clostridium Butyricum after colon polyp removal can lower the chance of polyps coming back. It is looking for people who had adenomas removed and are not already taking certain supplements or antibiotics.
Qingdao, ShandongAges 18–75 - NCT07645001Recruiting
Probiotics plus diabetes medicine for pregnancy blood sugar
This study tests whether adding probiotics (beneficial bacteria) to standard diabetes medication helps manage high blood sugar during pregnancy. Researchers hope this combination may improve health outcomes for both you and your baby.
Rawalpindi, Punjab ProvinceAges 18–45 - NCT07724990Recruiting
Probiotic for gut health in mild-to-moderate colitis
This trial tests a specific probiotic (a type of beneficial bacteria) to see if it can help people with mild to moderate ulcerative colitis by improving the balance of gut microbes. It may be an option if you have not used many advanced treatments before.
Roma, RMAges 18–80 - NCT07720232RecruitingPhase 4
Probiotic plus lipid-lowering for pancreatitis from high triglycerides
This trial tests if adding a probiotic (Bacillus subtilis and Enterococcus faecium) to standard lipid-lowering therapy helps people with mild pancreatitis caused by very high triglycerides. It aims to see if the combination reduces inflammation and speeds recovery.
Xiamen, FujianAges 18–65 - NCT03418857RecruitingPhase 1/Phase 2
Probiotics for weight- and blood-sugar–related gut health
This trial tests whether taking probiotics can improve gut health in people with early metabolic problems related to extra body fat, cholesterol, blood pressure, or blood sugar. It’s a Phase 1/2 study, meaning safety and early effectiveness are being tested.
University Park, PennsylvaniaAges 55–75 - NCT03613545RecruitingPhase 2/Phase 3
Fecal transplant to treat irritable bowel syndrome
This study tests whether transferring stool bacteria from a healthy donor (fecal microbiota transplantation) can improve symptoms of irritable bowel syndrome (IBS). It may help by changing the gut bacteria that can influence digestion and gut discomfort.
Guangzhou, GuangdongAges 18–75 - NCT03773003Recruiting
Study of fatigue caused by cancer or chronic fatigue
This study looks at why fatigue happens in people with cancer and, in some cases, in people with chronic fatigue conditions. It may help researchers better understand the causes of fatigue so future treatments can be improved.
Homburg, SaarlandAges 18–80 - NCT04871412RecruitingPhase 3
Surgery care program for lung or upper GI cancer patients
This trial tests an “integrative” support program around the time of cancer surgery to see if it improves care and outcomes for people having surgery for lung, stomach, or esophagus cancer. It may help by adding extra structured support during the peri-operative (around-surgery) period.
Ottawa, OntarioAges 18 years+ - NCT05178069RecruitingPhase 2
Probiotic supplement study for alcohol use disorder and liver injury
This Phase 2 trial studies whether a probiotic (LGG) can improve health in people with alcohol use disorder and alcohol-related liver injury. It’s not an alcohol treatment study, so participants are mainly joining to see how the supplement affects the body and liver-related outcomes.
Louisville, KentuckyAges 21–65 - NCT05288790RecruitingPhase 2
Study how gut chemicals and alcohol affect heart risk in HIV
This Phase 2 study looks at how “microbiome metabolites” (chemicals from gut bacteria) and alcohol may affect heart and blood vessel risk in people living with HIV. If you qualify, you may be asked to follow a study plan to see how these factors change health markers related to cardiovascular disease.
Nashville, TennesseeAges 18–89 - NCT05328999Recruiting
Study links fertility, pregnancy loss, and gut microbes
This trial studies how gut bacteria (your “microbiome”) may relate to infertility, recurrent pregnancy loss, and time to pregnancy. It may help researchers understand what could be changed to improve fertility outcomes.
Graz, StyriaAges 18–50 - NCT05484128Recruiting
Probiotic for kids taking acid-reducing medicine
This trial studies whether a specific probiotic (Lactobacillus reuteri) is helpful for children who need acid-reducing medicine for reflux or stomach discomfort. It may help improve stomach symptoms while they are on or need treatment with proton pump inhibitors.
BariAges 1–14 - NCT05512234Recruiting
Probiotic drops to reduce crying in breastfed baby colic
This trial tests whether probiotic Limosilactobacillus reuteri (a specific friendly gut bacteria) can shorten how long a baby cries when they have colic. If you join, you’ll keep feeding as usual and track crying in a diary across several visits.
CorkAges 3 weeks–2 months - NCT05524649Recruiting
Probiotics for healthy newborns’ poop bacteria balance
This study looks at whether giving probiotics to healthy newborns changes the bacteria in their stool. It may help researchers understand early gut health, but it is only for babies who meet specific health and timing requirements.
Alcaldía Coyoacán, PueblaAges 1 day–3 months - NCT05604846Recruiting
Probiotic drops for very preterm babies in Scandinavia
This trial studies whether giving probiotic supplements to extremely preterm newborns helps improve health outcomes. It’s meant for babies born very early, and the results could help guide safer early nutrition and care.
Solna, Stockholm CountyAges 5 months–6 months - NCT05698862Recruiting
Study how gut bacteria affect brain and behavior
This study looks at how gut bacteria may influence brain function and behavior, through a chemical called GABA. It may help researchers understand brain–gut links, though it is not yet a treatment trial.
ReadingAges 18–50 - NCT05767450Recruiting
Test for early type 1 diabetes in children
This study looks at children who have just started insulin for new-onset type 1 diabetes. It aims to test an intervention early in the course of the disease, which may help change how the immune system and diabetes progress.
Milan, MilanAges 7–17 - NCT05821010RecruitingPhase 2
Synbiotics and fecal transplant for non-alcoholic liver inflammation
This Phase 2 study tests whether taking special gut-helping products (synbiotics) and/or a fecal microbiota transplant can improve non-alcoholic steatohepatitis (NASH), a type of liver inflammation. It may help by changing gut bacteria that may affect liver health, but you must meet specific safety and medical criteria.
Amsterdam, North HollandAges 18–75 - NCT05894746Recruiting
Study to improve blood sugar and reduce inflammation
This study looks at how an intervention may improve blood sugar control and lower inflammation in the body. You may be able to take part unless you have a specific condition called celiac disease.
GothenburgAges 6 years+ - NCT06055894Recruiting
Plant-based diet and supplements for smoldering myeloma or MGUS
This study tests whether a plant-based diet and certain supplements can help people with smoldering multiple myeloma (SMM) or monoclonal gammopathy of undetermined significance (MGUS). Participants will learn to cook plant-based recipes and track their meals using a phone app.
Basking Ridge, New JerseyAges 18 years+
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Common questions
- Are there clinical trials for probiotic?
- Yes. Clin2 currently lists 224 recruiting probiotic studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a probiotic trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a probiotic trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.