Clinical trials
Progression clinical trials
Below are recruiting progression clinical trials, each written for real people, not researchers. We’re tracking 716 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04957537Recruiting
Speech and meaning therapy for primary progressive semantic aphasia
This study tests a “semantic rehabilitation” program—therapy focused on improving word meaning and understanding—for people with primary progressive semantic aphasia. If you qualify, it may help slow or improve language difficulties and daily communication.
ToulouseAges 18–100 - NCT04954820RecruitingPhase 2
Second round Lutathera for intestinal NET after regrowth
This Phase 2 study looks at whether giving Lutathera again (a second round) can control an intestinal neuroendocrine tumor (NET) that came back or progressed after the first treatment. It mainly targets adults whose scan shows tumors still take up the right “target” signal and who previously benefited for at least 12 months.
AngersAges 18 years+ - NCT04848740Enrolling by invitation
Tested implant for worsening thin corneas
This trial looks at whether placing a donor-like cornea “lenticule” implant can help people whose cornea is getting worse, becoming thin, and causing blurry or reduced vision. The goal is to see if the implant can improve corneal clarity and vision in progressive disease.
PristinaAges 20–60 - NCT04715399Recruiting
Research study collecting data for neurodegenerative diseases
This study collects health information from people with neurodegenerative diseases, some family members, and healthy controls to help researchers better understand these conditions. It may help future diagnosis and research, and participation may include noninvasive checks and other procedures depending on your situation.
Philadelphia, PennsylvaniaAges 18 years+ - NCT03887481Recruiting
Brain stimulation study for a language-loss dementia subtype
This trial tests whether a painless form of brain stimulation can improve language and thinking skills in people with the logopenic variant of primary progressive aphasia (a dementia that affects language). You may receive brain stimulation along with repeated clinic visits to track changes over time.
Baltimore, MarylandAges 50–80 - NCT03783416RecruitingPhase 1
Ixazomib safety study for people with multiple sclerosis
This early-phase study tests how safe ixazomib is for people with multiple sclerosis (MS). It focuses on targeting certain immune cells in MS and checks whether the treatment can be given safely.
London, Greater LondonAges 18–65 - NCT03174938Recruiting
BioFINDER 2 study for healthy aging and memory problems
This study uses brain scans and a spinal fluid test to better understand memory and thinking changes in different groups, from people with healthy thinking to early or established dementia. If you qualify, it may help researchers learn what’s driving these conditions and how they progress.
ÄngelholmAges 20–100 - NCT02605785Recruiting
Imaging study to track tau protein in PSP
This study uses brain imaging to look at a protein called tau in people with progressive supranuclear palsy (PSP). It aims to better understand the disease and how tau changes over time, which may help future treatments.
Rochester, MinnesotaAges 35 years+ - NCT01730131Recruiting
Study of PML in patients, at-risk people, and healthy volunteers
This study follows people with suspected or confirmed progressive multifocal leukoencephalopathy (PML), people at higher risk, and healthy volunteers. It uses visits, brain imaging (MRI), and stored biological samples to better understand how PML progresses and who is at risk.
Bethesda, MarylandAges 2–120 - NCT00537004Recruiting
Study of language in primary progressive aphasia
This study looks at how language changes in people with primary progressive aphasia. It may help researchers better understand the condition and how it affects speech and communication over time.
Chicago, IllinoisAges Any age - NCT07714018Recruiting
Comparing two weight loss programs for kidney cancer patients
This study tests two different weight loss programs to see which one helps prevent kidney cancer from growing in people with small kidney masses who are under active surveillance. It may help by improving overall health and potentially slowing cancer progression.
Buffalo, New YorkAges 18 years+ - NCT07741968Recruiting
Online program to ease fear of cancer returning
This study tests an online program designed to help women with advanced or certain types of breast or gynecologic cancer manage their fear of the disease progressing or returning. The program aims to reduce anxiety and improve quality of life.
Arcadia, CaliforniaAges 18 years+ - NCT07743164RecruitingPhase 3
Raludotatug deruxtecan for PARP-inhibitor-resistant ovarian cancer
This trial tests a new drug called raludotatug deruxtecan (with or without bevacizumab) for people with ovarian cancer that has grown despite PARP inhibitor maintenance treatment. The goal is to see if this drug can shrink tumors or slow the cancer's growth.
Fountain Valley, CaliforniaAges 18 years+ - NCT07144137Recruiting
Observation study for geographic atrophy progression
This study observes how geographic atrophy (an advanced form of dry age-related macular degeneration) changes over a short period. If you have this condition in both eyes and meet certain vision and eye health criteria, you may be able to join this non-treatment study to help researchers learn more about the disease.
Mountain View, CaliforniaAges 55 years+ - NCT07617090Recruiting
Testing progressive glasses for reading and distance in presbyopia
This trial compares two types of progressive glasses to see which works better for seeing at arm's length and up close. It is for people with presbyopia who have relatively mild vision problems.
Seville, AndalusiaAges 52–67 - NCT07876570Recruiting
Predicting memory decline with brain and blood tests
This study follows older adults with normal memory, mild memory problems, or dementia over a year to see if brain scans and blood tests can predict who will get worse. It may help find early warning signs of Alzheimer's and other dementias.
Beijing, Beijing MunicipalityAges 50 years+ - NCT07711002RecruitingPhase 3
Saruparib with standard therapy for metastatic hormone-sensitive prostate cancer
This trial tests a new drug called saruparib, which may help keep prostate cancer from growing. It is for men whose cancer has spread and who have already received certain treatments. The study combines saruparib with a standard hormone therapy to see if it works better than the hormone therapy alone.
Hot Springs, ArkansasAges 18 years+ - NCT06990087RecruitingPhase 2
T-cell therapy for progressive multifocal leukoencephalopathy (PML)
This trial tests a T-cell therapy for people with PML, a rare brain infection. It aims to boost your immune system to fight the virus causing PML. You may be eligible if you have PML not caused by HIV, natalizumab, or certain recent treatments.
München, BavariaAges 18 years+ - NCT03853447Recruiting
Study of inflammation changes from pancreas flare to chronic disease
This trial studies how “inflammation” in the pancreas changes over time—going from a first or repeated attack to long-term (chronic) pancreatitis. It may help doctors understand what drives progression and identify people at higher risk for chronic disease.
Hvidovre, Capital Region DenmarkAges 18–70 - NCT04581122Recruiting
Tests how lymph node surgery choices affect lung nodule outcomes
This study looks at whether different lymph node removal methods during lung surgery change outcomes for certain abnormal lung spots. It focuses on ground-glass nodules that stay the same after treatment-free observation and have a mostly solid portion on CT.
ShanghaiAges 18–75 - NCT04026360Recruiting
Study early lung, virus, and gut changes in children with cystic fibrosis
This study looks at how a child’s early lung function, viral infections, and gut (microbiome) changes affect cystic fibrosis over time. It may help doctors understand what predicts how lung disease develops, which could improve future care.
BernAges birth–18 years - NCT04723888Recruiting
Supplements to slow aneurysm growth and prevent rupture
This trial studies whether alpha-ketoglutarate, a supplement, can slow the growth of an abdominal aortic aneurysm and reduce the risk of rupture. It may help people whose aneurysm size is in a specific range by tracking changes over time and watching for safety.
ShanghaiAges 50 years+ - NCT03981276Recruiting
Study aims to understand inherited walking stiffness disorders
This study looks at the causes and biology (“biomarkers”) of hereditary spastic paraplegias and related conditions. You may join as someone with the condition, a family member without symptoms, or a healthy person, to help researchers understand what’s happening in the nervous system.
InnsbruckAges Any age - NCT04905056RecruitingPhase 2
Ablation treatment for lung ground-glass nodules that don’t go away
This Phase 2 trial studies whether a procedure called “ablation” is safe and effective for certain lung cancers that appear as ground-glass spots on CT scans and do not improve after 3 months. It may help people who cannot fully have surgery for their condition.
Shanghai, Shanghai MunicipalityAges 18–85
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Common questions
- Are there clinical trials for progression?
- Yes. Clin2 currently lists 716 recruiting progression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a progression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a progression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.