Clinical trials
Prosthetic Joint Infections of Knee clinical trials
Below are recruiting prosthetic joint infections of knee clinical trials, each written for real people, not researchers. We’re tracking 26 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07788404Recruiting
Study of rifampin levels in patients with bone or joint staph infections
This study looks at how the antibiotic rifampin behaves in the body when used to treat staph infections in bones or joints. It may help doctors better dose the drug for future patients.
Paris, ParisAges 18 years+ - NCT06293352Recruiting
Comparing two antibiotic spacers for knee infection
This trial compares two types of antibiotic spacers for people with a long-term knee replacement infection. It tests whether a spacer made entirely of antibiotic cement or one with a metal core works better to treat the infection before a new knee replacement.
Chicago, IllinoisAges 18 years+ - NCT07214311RecruitingPhase 2/Phase 3
A trial of PLG0206 to prevent knee joint infection after surgery
This trial tests if a new drug called PLG0206 can stop a knee joint infection from coming back after a surgery called DAIR. DAIR cleans the infected area and keeps the artificial knee in place, and this study wants to see if adding PLG0206 helps prevent the infection from returning.
Sarasota, FloridaAges 18–80 - NCT06771050RecruitingPhase 4
Antibiotics and surgery for hip and knee joint infections
This trial tests different antibiotic types and durations, plus surgical approaches, for people with a current joint infection in a hip or knee. It aims to find the best way to treat the infection and prevent it from coming back.
Garran, Australian Capital TerritoryAges 18 years+ - NCT06670885Enrolling by invitation
New DNA test for joint replacement infections
This trial uses advanced molecular methods to better diagnose infections in hip or knee replacement joints. The goal is to find infections more accurately so you can get the right treatment sooner.
Milan, MilanoAges 18 years+ - NCT05902221RecruitingPhase 3
Rifampicin add-on for knee, hip, or shoulder implant infections
This Phase 3 trial tests whether adding rifampicin improves outcomes for implant infections caused by a specific germ (Cutibacterium acnes) after surgery. If you have such an infection and the germ is susceptible, you may be able to receive a rifampicin-based treatment plan.
AnnecyAges 18 years+ - NCT04858217Recruiting
Testing blood and joint fluid tests for hip or knee infection
This trial checks how accurate certain blood tests and joint-fluid (synovial) tests are at identifying infections around hip or knee replacements. It also looks at whether these tests are worth the cost, to help doctors choose the best next step.
BolognaAges 18 years+ - NCT02801253Recruiting
Study of infections around hip, knee, or shoulder implants
This study follows people who have an infection around a hip, knee, or shoulder implant (prosthesis). It uses standard infection tests (like cultures and blood tests) to confirm the diagnosis and better understand this problem after surgery.
Paris, Île-de-France RegionAges 18 years+ - NCT06782295RecruitingPhase 4
Comparing two implant types in knee revision surgery
This study compares two types of knee implants (CCK vs PS) used during revision total knee replacement. The goal is to see which one works better in patients who need a second knee surgery.
Chicago, IllinoisAges 18 years+ - NCT07324954RecruitingPhase 1
Methylene blue for knee replacement surgery
This study tests if using a blue dye called methylene blue during knee replacement surgery can help doctors see and clean out infections better. It may help people having a first-time knee replacement or those with an infected knee replacement.
Miami, FloridaAges 18 years+ - NCT06919913Recruiting
Probiotics for joint infection surgery
This study tests if taking probiotics before and after surgery can help your immune system fight infection in a hip or knee replacement. You would be given a probiotic or a placebo alongside your standard treatment.
New York, New YorkAges 18–90 - NCT05805774Recruiting
Compare fixing versus replacing a fractured thigh bone
This study looks at the best surgical option for an acute (new) fracture of the lower thigh bone near a stable knee replacement. It compares surgery that “fixes” the bone versus surgery that “replaces” part of the bone to help you walk again safely.
Toronto, OntarioAges 65 years+ - NCT06172010RecruitingPhase 4
Rifampicin plus antibiotics for staph joint replacement infection
This study tests whether adding the antibiotic rifampicin to standard treatment works better than standard treatment alone for staph infections in hip or knee replacements. The goal is to find a more effective way to clear the infection and avoid more surgeries.
Leiden, Zuid HollansAges 18 years+ - NCT07107685Recruiting
Joint replacement infections in critical care patients
This trial looks at infections in hip, knee, or shoulder replacements in people who needed critical care and later passed away. It aims to learn from their medical information to better prevent and treat similar infections.
Paris, FranceAges 18 years+ - NCT07473089Recruiting
Swiss study on joint replacement revision for infection
This study looks at people who need a second (revision) surgery on a large joint replacement like a hip, knee, shoulder, ankle, or elbow because of a suspected or confirmed infection. The goal is to learn more about these infections and improve care.
AarauAges 18 years+ - NCT06636669Enrolling by invitationPhase 4
Probiotics to prevent repeat joint infection after replacement surgery
This trial tests whether taking probiotics can help prevent another infection in people who have had a hip or knee replacement that became infected. If you are scheduled for revision surgery due to an infection, this study may be a good fit.
Boston, MassachusettsAges 18–90 - NCT05642013Recruiting
Short interval exchange surgery for infected hip or knee implants
This study compares how to replace an infected hip or knee implant using a two-step surgery with a shorter waiting time. It aims to reduce the time between surgeries while still safely treating the infection.
MontpellierAges 18 years+ - NCT04297592Enrolling by invitationPhase 4
Antibiotics to prevent infection after hip or knee replacement
This trial studies whether giving antibiotics before and/or after surgery can lower the chance of a serious joint infection after elective hip or knee replacement. It’s aimed at people at higher risk for infection.
Iowa City, IowaAges 18–99 - NCT04821154Recruiting
Testing outcomes after revision knee replacement with a Persona system
This study looks at how well a specific revision knee replacement system (the Persona system) works after earlier knee problems or surgeries. You may be eligible if you need a revision knee and can follow follow-up care instructions; the trial also checks for certain infection, bone, and health-safety factors.
Fayetteville, ArkansasAges 18 years+ - NCT03713528Enrolling by invitationPhase 4
Antibiotic placed in bone to help save an infected knee implant
This trial tests whether putting antibiotics directly inside the bone during surgery can improve outcomes for an infected knee prosthesis when the implant is being kept. It may help more people avoid needing full implant removal and replacement.
San Francisco, CaliforniaAges 18 years+ - NCT03048201Recruiting
Total Knee Replacement Registry Study for a Specific Knee Implant
This study tracks outcomes for people getting a total knee replacement using a specific knee implant system. It may help doctors understand which patients do best and how the implant performs over time.
Rancho Mirage, CaliforniaAges 22 years+ - NCT07264296Enrolling by invitation
Infection after bone cancer surgery with a big joint implant
This trial studies infections that happen after surgery for bone cancer where a large artificial joint is placed. It aims to understand why some patients get infections, which may lead to better prevention or treatment.
GothenburgAges Any age - NCT04672525RecruitingPhase 3
Rifabutin versus rifampicin for knee or hip staph implant infection
This Phase 3 trial compares two antibiotics—rifabutin and rifampicin—for treating staphylococcal (staph) infections around hip or knee joint implants when the implant is kept in place after cleaning (DAIR). It aims to see which drug works better to stop the infection from coming back.
AmiensAges 18 years+ - NCT05936593Recruiting
Compare two knee implant positions during robotic knee replacement
This study compares how a knee implant’s components “fit” and move when placed in two different ways during robotic knee replacement. It uses special imaging to see which placement works best for stability and long-term performance.
Zoetermeer, South HollandAges 18–70
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Common questions
- Are there clinical trials for prosthetic joint infections of knee?
- Yes. Clin2 currently lists 26 recruiting prosthetic joint infections of knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a prosthetic joint infections of knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a prosthetic joint infections of knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.