Clinical trials
Pulmonary Hypertension clinical trials
Below are recruiting pulmonary hypertension clinical trials, each written for real people, not researchers. We’re tracking 247 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06351345RecruitingPhase 2
Xenon imaging study for pulmonary hypertension patients on sotatercept
This trial uses a special imaging technique (xenon MRI) to see how well the lungs are functioning in people with pulmonary arterial hypertension (PAH) who are being treated with the drug sotatercept. It aims to understand if the drug improves lung function.
Durham, North CarolinaAges 18–75 - NCT01712620RecruitingPhase 2
Spironolactone for pulmonary arterial hypertension
This study tests whether spironolactone, a water pill that helps the heart and blood vessels, can improve symptoms in people with pulmonary arterial hypertension (PAH), a condition of high blood pressure in the lungs. It's a phase 2 trial, meaning it's early but may offer a new treatment option.
Bethesda, MarylandAges 18–100 - NCT05610631Recruiting
Switzerland heart-lung pressure registry for people with PH
This is a registry that collects information from people who have pulmonary hypertension (high blood pressure in the lungs). It helps researchers better understand the condition and may support future studies.
ZurichAges Any age - NCT07852403Recruiting
Sleep problems and outcomes in pulmonary arterial hypertension
This study looks at how sleep-disordered breathing (abnormal breathing during sleep) affects the long-term health of people with pulmonary arterial hypertension (PAH), a type of high blood pressure in the lungs. By participating, you will have a sleep study and be followed over time to see how your breathing during sleep relates to your PAH outcomes.
BeijingAges 18 years+ - NCT07824674RecruitingPhase 2/Phase 3
On-demand sildenafil for exercise capacity in pulmonary arterial hypertension
This trial tests whether taking sildenafil (a medicine that helps relax blood vessels) on demand, compared to a sugar candy placebo, can improve exercise capacity in people with pulmonary arterial hypertension (PAH). Participating may help you exercise more easily and contribute to better treatment options.
Zurich, Canton of ZurichAges 18–80 - NCT07713914RecruitingPhase 4
Triple therapy vs sildenafil dose increase for PAH
This study compares two approaches for people with PAH whose current treatment (a combination of sildenafil and an endothelin receptor antagonist) needs to be stepped up. Half the participants will add a third medicine (iloprost or selexipag), while the other half will increase their sildenafil dose. The goal is to see which strategy works better for improving symptoms and lowering risk.
São Paulo, São PauloAges 18 years+ - NCT06454838Recruiting
Exercise and blood vessel health in children with pulmonary hypertension
This study looks at how exercise affects the lungs, blood vessels, and oxygen use in children with pulmonary arterial hypertension (high blood pressure in the lungs). It compares them to healthy children to understand how the condition impacts the body.
Ankara, ÇankayaAges 6–18 - NCT07498244Recruiting
Collagen fingerprinting to understand lung blood pressure
This study uses a special imaging method to look at collagen (a building block of lung tissue) in people with COPD or pulmonary fibrosis. Researchers want to see if collagen patterns can help doctors better understand and treat high blood pressure in the lungs (pulmonary hypertension).
Graz, StyriaAges 18 years+ - NCT07457762Recruiting
Reminder app for pulmonary hypertension inhaler
This study tests if a smartphone app can help people with pulmonary arterial hypertension (PAH) stick to their inhaled iloprost treatment. It is for adults already on this treatment at a specific clinic in Brazil.
São Paulo, São PauloAges 18 years+ - NCT07366879Recruiting
Exercise program for newly diagnosed pulmonary hypertension
This study tests whether a home-based exercise program, added to your regular medications, can help people who are newly diagnosed with pulmonary arterial hypertension feel better and improve their daily function.
GlasgowAges 18 years+ - NCT07272798Recruiting
Heart confidence after pulmonary hypertension surgery
This study looks at how confident patients feel about managing their heart health after surgery for chronic thromboembolic pulmonary hypertension. It may help doctors understand how to better support recovery.
Damascus, Rif-dimashq GovernorateAges Any age - NCT07149935Recruiting
Exercise training for pulmonary arterial hypertension
This study tests whether a special exercise training program can help people with pulmonary arterial hypertension (PAH) feel better and stay stable. If you have mild-to-moderate PAH and are on stable medication, you may be able to join.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07140484RecruitingPhase 4
Sotatercept for pulmonary arterial hypertension
This study tests a new medication called sotatercept for people with pulmonary arterial hypertension (PAH) who are already on at least two other PAH treatments. The goal is to see if adding sotatercept can improve symptoms and exercise ability.
Edmonton, AlbertaAges 18 years+ - NCT04756076Recruiting
Study heavy metal levels in pulmonary hypertension patients
This study looks at whether heavy metals in the body—and an imbalance of important minerals—are different in people with pulmonary arterial hypertension. It may help researchers understand possible causes and targets for future treatments.
Louisville, KentuckyAges 18 years+ - NCT06992440RecruitingPhase 2
Empagliflozin for better right heart function in pulmonary hypertension
This trial tests if a diabetes drug can help people with pulmonary arterial hypertension whose right heart function is reduced. Participants take empagliflozin or a placebo for 24 weeks to see if heart function improves.
Baltimore, MarylandAges 18 years+ - NCT06931886Enrolling by invitation
Breathing training for pulmonary hypertension
This trial tests if special breathing exercises can help people with pulmonary hypertension. You may join if your condition is stable and you haven't smoked in the last 10 years.
Tucson, ArizonaAges 18 years+ - NCT06872112RecruitingPhase 1
Artesunate for pulmonary arterial hypertension safety study
This trial tests if artesunate, a malaria drug, is safe and tolerable for people with pulmonary arterial hypertension (PAH). It may offer a new treatment option for PAH patients whose symptoms persist despite using two or more standard therapies.
Stanford, CaliforniaAges 18–60 - NCT06804122Recruiting
Exercise rehab for pulmonary arterial hypertension
This trial tests a supervised exercise program for people with pulmonary arterial hypertension (PAH), a type of high blood pressure in the lungs. It aims to see if regular exercise can improve your daily function and quality of life.
Tampere, PirkanmaaAges 18 years+ - NCT06770023RecruitingPhase 1
Bridge to lung transplant with ECMO for right heart failure
This study tests a special heart-lung support machine (ECMO) for people waiting for a lung transplant whose heart is failing due to high blood pressure in the lungs. The machine helps rest the heart and lungs until transplant surgery.
Jacksonville, FloridaAges 18–80 - NCT01347216Recruiting
COMPERA study for lung vessel pressure medicines
This study follows people with different types of high blood pressure in the lungs (pulmonary hypertension) to see how starting specific lung blood vessel medicines affects outcomes. It may help improve how clinicians choose and monitor treatment over time.
LeuvenAges 1 week+ - NCT05340023Recruiting
Test using lung scan patterns to diagnose a heart-lung condition
This study looks at patterns from specialized lung scan tests to help diagnose chronic thromboembolic pulmonary hypertension (a long-term problem with blood flow in the lungs after blood clots). If your results suggest this condition and you need a procedure to check heart pressure, you may be asked to join so the researchers can improve diagnosis.
Saint-EtienneAges 18 years+ - NCT04194632Recruiting
Right heart pacing study for pulmonary hypertension
This study tests whether a temporary pacemaker placed in the right heart chamber can improve heart function in people with pulmonary arterial hypertension. It aims to see if pacing can help the right heart pump more efficiently, potentially reducing symptoms.
San Francisco, CaliforniaAges 18–75 - NCT02249923Recruiting
Children with pulmonary hypertension registry in Spanish or English
This registry study collects information from children and families affected by pulmonary hypertension to better understand the condition. It may help researchers track outcomes over time and improve future care.
Palo Alto, CaliforniaAges 1 day–21 years - NCT05745961Recruiting
Measuring a lung protein in pulmonary artery hypertension
This study measures how much of a specific lung protein (TSPO) is present in people with pulmonary artery hypertension. The results may help researchers better understand the disease and guide future treatments.
LondonAges 25–75
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Common questions
- Are there clinical trials for pulmonary hypertension?
- Yes. Clin2 currently lists 247 recruiting pulmonary hypertension studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pulmonary hypertension trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pulmonary hypertension trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Pulmonary Arterial Hypertension
- Chronic Thromboembolic Pulmonary Hypertension
- Pulmonary Artery Hypertension
- Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
- Idiopathic Pulmonary Arterial Hypertension
- Pulmonary Hypertension Due to Lung Diseases and Hypoxia
- Pulmonary Hypertension (Diagnosis)
- Pulmonary Hypertension Due to Left Heart Disease
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.