Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 507 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06177184Recruiting
Donor milk for full-term cesarean-born babies
This study tests whether giving donor breast milk to full-term babies born by C-section can improve their gut health. If your baby was born by C-section and you plan to breastfeed, this trial may be a good fit.
Calgary, AlbertaAges 9 months+ - NCT06173778RecruitingPhase 2
Semaglutide for weight management after quitting smoking
This study tests whether the drug semaglutide (often used for weight loss) can help people who quit smoking avoid gaining weight. It's for people who are overweight or have weight-related health issues and want to stop smoking.
Austin, TexasAges 18–75 - NCT06143306RecruitingPhase 4
Adding a second numbing shot for shoulder replacement pain
This study tests whether adding an extra numbing shot (pectoserratus block) to the standard shoulder block reduces pain after total shoulder replacement. It may help you recover more comfortably and use fewer pain medicines.
Minneapolis, MinnesotaAges 18–85 - NCT06126614RecruitingPhase 3
Infection prevention in joint replacement surgery
This trial tests a way to prevent infections for people getting a hip or knee replacement. It compares different methods to see which works best and may help lower your risk of infection after surgery.
Hamilton, OntarioAges 18 years+ - NCT06127589Recruiting
Quit for Kids: help parents quit smoking and protect children
This study offers a program to help parents who smoke quit for good, while protecting their young children from secondhand smoke. It uses text messaging and support to make quitting easier.
Hong KongAges 18 years+ - NCT06122727Recruiting
Custom vs standard knee replacement for better fit
This trial compares custom-made knee replacements (built to fit your unique knee shape) with standard, off-the-shelf knee replacements. It aims to see if a custom implant leads to better function and satisfaction after surgery.
BolognaAges 40–70 - NCT05831709Recruiting
Hormone therapy and supervised exercise in menopausal women
This study looks at how hormone replacement therapy and a supervised exercise program may change body composition, heart health risk, and insulin sensitivity in postmenopausal women. It may help participants understand which combination works best for metabolic and cardiovascular health after menopause.
GhentAges 45–65 - NCT06000943Recruiting
Bleeding and clot risk after heart valve procedure
This study looks at patients who had a TAVR procedure (a new valve put in the heart) to understand their risk of bleeding or clots over the next year. It tracks changes in blood thinner medications at 1 month, 90 days, and 1 year to help doctors personalize care.
AalstAges 18 years+ - NCT05966519Recruiting
Study testing flexible planning for knee replacement with ROSA
This study looks at how flexible pre-op planning can be when you get a total knee replacement using the ROSA system. It may help doctors fine-tune surgery planning while keeping outcomes safe and effective.
Fukuoka, FukuokaAges 20 years+ - NCT04905017Recruiting
Transcatheter valve treatment study for severe tricuspid valve leakage
This study tests a new, catheter-based procedure to treat moderate-to-severe leaking of the tricuspid valve (a heart valve on the right side). It’s for people who are high surgical risk and might benefit from replacing the valve without open-heart surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT05738330Recruiting
Symptom reporting during hemodialysis care
This study looks at how well a new phone or computer system can help people on hemodialysis report their symptoms. It may improve symptom tracking so clinics can better understand and respond to what you feel during treatment.
Waltham, MassachusettsAges 18 years+ - NCT05877300RecruitingPhase 1
Test a new esophagus implant to rebuild a short esophagus segment
This Phase 1 study tests the safety and feasibility of a new esophagus implant for people who need only a short (about 6 cm or less) section of their esophagus rebuilt after serious injury or scarring. If it does not work, you must be willing to have a planned “rescue” surgery later.
Los Angeles, CaliforniaAges 18 years+ - NCT05855330RecruitingPhase 2
Arginine treatment for kids hospitalized with COVID-19
This Phase 2 trial tests whether replacing the body’s arginine (an amino acid) can improve outcomes for children and young adults hospitalized with COVID-19. It may help the immune response, but you must meet several safety criteria to join.
Atlanta, GeorgiaAges 3–21 - NCT05815199Recruiting
E-cigarettes to help smokers with serious mental illness cut down
This study tests whether e-cigarettes can help people who smoke a lot reduce cigarette use (without requiring them to quit completely). It is designed for adults with serious mental illness and focuses on harm reduction and follow-up over time.
New York, New YorkAges 21 years+ - NCT05817539Recruiting
Early circulation-focused care during kidney dialysis in ICU
This trial looks at whether starting dialysis-related care early, aimed at improving blood flow to tissues, can help people in the ICU who have sudden kidney failure. It may help reduce problems related to poor tissue circulation, but it is very specific about ICU illness and current treatments.
AjaccioAges 18 years+ - NCT05796375RecruitingPhase 2
Urine testing instead of repeat bladder scope checks
This Phase 2 study tests whether urine tests can help monitor “non-muscle-invasive” bladder cancer without doing as many invasive bladder scopes (cystoscopies). If you qualify, you may be able to replace some scope visits with urine sample testing while still keeping close watch for cancer coming back.
West Haven, ConnecticutAges 18 years+ - NCT05799222Recruiting
Nutrition program for obesity and diabetes risk
This trial tests a medically guided nutrition program to help improve weight and blood sugar in adults with obesity or early diabetes risk. It specifically targets people who meet income guidelines and don’t already use most diabetes or anti-obesity medicines.
Boston, MassachusettsAges 18–65 - NCT05792189Recruiting
Knee fracture surgery: plates vs knee replacement for older adults
This trial compares two ways to treat certain lower-thigh (distal femur) fractures near the knee: using plates/screws or doing a knee replacement. It aims to see which option works better for recovery and long-term outcomes.
Gainesville, FloridaAges 55–100 - NCT05800600RecruitingPhase 2
Iron treatment to lower anemia during pre-surgery chemotherapy
This trial tests whether giving iron (iron sucrose) can reduce anemia during chemotherapy before curative surgery. It may help you feel better and have smoother treatment by improving low blood counts caused by iron deficiency.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05779787Recruiting
Registry after aortic valve procedure to guide future care
This registry is for people with severe, symptomatic aortic valve narrowing who are planning a TAVI procedure (a less invasive valve replacement). It aims to better track and improve how patients do after the valve is replaced, based on how the procedure is planned and performed.
Milan, LombardyAges 18 years+ - NCT05790486Recruiting
Take a Break program for adult smokers in rural areas
This trial tests a text-based program to help adults who smoke but are not ready to quit yet. It may help you think about quitting when you’re ready, without pushing you to stop right away.
Winston-Salem, North CarolinaAges 18 years+ - NCT05758701RecruitingPhase 4
CT scan study for people getting TAVR
This trial studies your abdomen using a CT scan around the time you receive TAVR (a heart valve procedure). The goal is to understand how the abdomen area looks on CT and what that might mean for care.
Baltimore, MarylandAges 18–88 - NCT05723588RecruitingPhase 2
TMS brain stimulation to help veterans quit smoking with PTSD
This Phase 2 study tests whether targeted brain stimulation (TMS) can improve smoking quit outcomes in Veterans who also have PTSD. It also uses brain imaging (MRI) to understand what changes in the brain may help people quit.
Durham, North CarolinaAges 18–75 - NCT05722561RecruitingPhase 2
E-cigarettes to reduce smoking in opioid use disorder
This Phase 2 study tests whether e-cigarettes can help people who use opioids (and also smoke cigarettes) cut down on combustible cigarette smoking. It looks at whether switching to e-cigarettes for “harm reduction” is safe and helps you smoke fewer cigarettes without requiring you to quit completely.
New York, New YorkAges 21–75
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Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 507 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.