Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 502 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07239817Recruiting
Nerve block plus numbing medicine for hip fracture surgery
This study tests a special nerve block (PENG block) combined with a numbing medicine injection around the hip joint to provide better pain relief after hip replacement surgery for a broken hip. It aims to see if this approach can reduce pain and the need for strong pain medicines.
MilanAges 18 years+ - NCT07436793RecruitingPhase 2
Progestin therapy before hysterectomy for endometrial cancer
This trial tests whether taking progestin (a hormone medication) before scheduled surgery can improve outcomes for women with a type of uterine cancer called endometrioid adenocarcinoma. You might be able to join if you are planning to have a hysterectomy and are open to hormone therapy before the procedure.
Iowa City, IowaAges 18 years+ - NCT07270068Recruiting
Diabetes remission through lifestyle change for Malaysian patients
This study tests whether a lifestyle program can help Malaysian adults with recently diagnosed type 2 diabetes and overweight or obesity achieve remission of their diabetes. If you qualify, you’ll get support to change your diet and activity habits.
Seremban, Negeri SembilamAges 18–70 - NCT07278310Recruiting
Siegel Valve for Severe Aortic Stenosis (TAVR)
This study tests a new replacement valve called the Siegel, placed through a catheter in your leg (TAVR), for people with severe aortic stenosis. It aims to see if it is safe and effective for patients at low, intermediate, or high surgical risk.
Atlanta, GeorgiaAges 18 years+ - NCT07292857Recruiting
Respiratory infection risk in postmenopausal women on HRT or not
This study looks at how the risk of respiratory infections (like colds or flu) may differ in postmenopausal women who use hormone replacement therapy (HRT) and those who do not. You will wear a smartwatch for six months and track your health through a smartphone app.
BernAges 40–60 - NCT07293936Recruiting
Study of blood filter after kidney therapy
This study is for adults who are starting continuous kidney replacement therapy (CRRT) for kidney failure. It looks at how well the filter removes waste, and excludes people on ECMO.
Iowa City, IowaAges 18 years+ - NCT07315932Recruiting
Hormone therapy views in teenagers
This trial is a survey asking girls aged 11 to 17 how they feel about starting hormone replacement therapy for hypogonadism. The goal is to understand their experiences and views.
StrasbourgAges 11–18 - NCT07348627RecruitingPhase 3
Opioid-free hip replacement study
This trial tests if using fewer opioids after hip replacement surgery can still control pain well. It uses a specific type of hip replacement called anterior total hip arthroplasty and aims to help patients recover with less reliance on strong pain medicines.
Atlanta, GeorgiaAges 18 years+ - NCT07360392Recruiting
Nerve block comparison for knee replacement pain
This study compares two numbing techniques (nerve blocks) for pain relief after knee replacement surgery. The goal is to find which one works better and helps you recover with less pain.
AmasyaAges 18–80 - NCT07364045Recruiting
Diet and diabetes remission in overweight adults
This study tests whether a special diet can help reverse type 2 diabetes or prediabetes in people who are overweight. It compares people with type 2 diabetes, prediabetes, and healthy controls to see how weight loss affects fat in the pancreas.
EdinburghAges 45–79 - NCT07366671Recruiting
Testing a new wire for heart valve replacement safety
This trial tests a special wire to monitor heart function during a less invasive valve replacement procedure (TAVI). It aims to improve safety and understanding of the heart's response during the procedure.
Eindhoven, North BrabantAges 50 years+ - NCT07368322Recruiting
Y-incision vs. standard surgery for aortic root enlargement
This study tests a new surgical method (Y-incision) to enlarge the aortic root during valve replacement, which may help people with a small valve opening. It compares this technique to standard approaches to see if it can prevent the new valve from being too small.
HaifaAges 18–80 - NCT07370467Recruiting
MRI study for mitral & tricuspid valve repair
This study uses MRI scans to take detailed pictures of the heart before and after a valve repair procedure. It helps doctors better understand how these new, less invasive treatments affect heart function.
Milan, MilanAges 18 years+ - NCT07373184Recruiting
Virtual planning for jaw joint replacement
This study looks back at past jaw joint (TMJ) replacement surgeries to see how virtual planning helped. If you already had this surgery at a specific hospital between 2010 and 2025, you might be included.
LundAges Any age - NCT07392515Recruiting
Digital rehab for hip fracture recovery in older adults
This trial tests whether a digital rehabilitation program can help older adults recover their thinking and movement skills after hip fracture surgery. It uses sensors and digital tools to guide therapy, making it easier to do from a rehabilitation ward.
Messina, ItalyAges 65–89 - NCT01737528Recruiting
Transcatheter heart valve therapy registry for adults
This registry collects information from adults who receive a less invasive heart valve procedure (done through a catheter). The goal is to learn how these treatments work in real-world patients and care over time.
Washington D.C., District of ColumbiaAges 18 years+ - NCT02230826Recruiting
Follow-up study of long-term outcomes after hip replacement
This is an observation (not experimental) study that follows adults who receive a Corin hip replacement to see how well they do long-term. It may help doctors understand which patients benefit most and how hip implants perform over time.
BordeauxAges 18 years+ - NCT02692092Recruiting
Records for your hip or knee replacement care
This registry collects information about people who have a hip or knee replacement at a HealthEast hospital. It helps researchers and the hospital system understand outcomes and improve care.
Saint Paul, MinnesotaAges 18 years+ - NCT07418593RecruitingPhase 4
Blood test for pancreas function in chronic pancreatitis
This trial tests a new blood test to measure how well your pancreas works. It may help people with chronic pancreatitis understand their condition and quality of life.
Baltimore, MarylandAges 18 years+ - NCT07425457Recruiting
Cold nerve treatment before knee replacement surgery
This trial tests a cold therapy on nerves before knee replacement to reduce pain. It may help you recover with less discomfort after surgery.
AthensAges 18 years+ - NCT07441824RecruitingPhase 3
Enzyme pills for severe pancreas damage
This trial tests if taking pancreatic enzyme pills can help people who have lost weight after a severe first-time pancreas attack with more than half of the organ damaged. It aims to see if the pills improve nutrition and recovery.
Guwahati, AssamAges 18–60 - NCT07466875Recruiting
Ear stimulation for nicotine withdrawal in psychiatric patients
This trial tests whether gentle electrical stimulation on the ear can help relieve nicotine withdrawal symptoms for smokers who are in a psychiatric hospital and must stop smoking. It is added on top of standard nicotine replacement therapy.
Nantou CityAges 18–65 - NCT07473089Recruiting
Swiss study on joint replacement revision for infection
This study looks at people who need a second (revision) surgery on a large joint replacement like a hip, knee, shoulder, ankle, or elbow because of a suspected or confirmed infection. The goal is to learn more about these infections and improve care.
AarauAges 18 years+ - NCT07485803RecruitingPhase 4
Methadone for pain after knee replacement
This study tests whether methadone, a type of pain medicine, helps control pain better after knee replacement surgery. It is for people who have not used narcotics recently and are otherwise healthy.
Denver, ColoradoAges 21–75
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Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 502 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.