Clinical trials
Retinal Disease clinical trials
Below are recruiting retinal disease clinical trials, each written for real people, not researchers. We’re tracking 77 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05724641Recruiting
MRI test of eye blood flow in specific optic nerve conditions
This study uses a special MRI scan to measure blood flow to the eye and check how consistently the results match over time. It may help doctors better assess certain optic nerve problems, especially in people without major cardiovascular risk factors.
Brussels, Brussels CapitalAges 18 years+ - NCT05906953RecruitingPhase 1/Phase 2
HG004 gene therapy for RPE65 vision loss
This Phase 1/2 trial tests the safety and early effectiveness of HG004 (a gene therapy) in people with Leber congenital amaurosis caused by RPE65 gene changes. It aims to see whether treating the eye can improve or stabilize vision-related measures while monitoring side effects.
Sacramento, CaliforniaAges 6–50 - NCT06287645Recruiting
Eye photos for diabetes patients
This trial takes colored photos of the back of your eye to help experts identify diabetes-related changes. It may help detect eye problems early in people with diabetes.
KarachiAges 20 years+ - NCT07006649Recruiting
Study of blood flow in the eye for pseudoxanthoma elasticum
This study looks at blood flow in a layer of the eye called the choriocapillaris in people with pseudoxanthoma elasticum (PXE). It compares these findings with healthy volunteers to understand eye changes before they become severe.
AngersAges 18 years+ - NCT07458516Recruiting
Observing eye disease progression in type 2 diabetes
This study closely follows people with type 2 diabetes who have early signs of diabetic retinopathy (damage to the retina from diabetes) to see how the condition changes over time. It does not test a new treatment but monitors the eye's health closely. It may be a good fit if you have diabetic retinopathy that does not need immediate treatment.
CoimbraAges 35–80 - NCT07425106Enrolling by invitation
Comparing a low-cost eye scanner for Alzheimer's research
This study uses a special, low-cost eye scanner to look at the back of the eye (retina) in people with early Alzheimer's or mild memory problems. It aims to find changes that might help with early detection.
Durham, North CarolinaAges 18–85 - NCT07545473Recruiting
Eye Imaging to Detect Brain Disease Markers
This study uses a special camera to photograph the back of your eye in detail. Researchers believe changes in the eye may reflect brain diseases like Alzheimer's or Parkinson's, and this imaging could help detect these conditions earlier.
Melbourne, VictoriaAges 30 years+ - NCT06319872RecruitingPhase 1
Study of disulfiram for vision in retinal degeneration
This trial tests whether disulfiram, a drug used for alcohol use disorder, can improve vision in people with retinal degeneration. You must have an alcohol use diagnosis and agree to avoid alcohol for 6 months.
Rochester, New YorkAges 18 years+ - NCT07359664Recruiting
Eye scans for heart health: a study of blood vessels
This study uses an eye scan called OCTA to look at blood vessels in the retina. It compares people with certain heart or blood vessel conditions (like high blood pressure or diabetes) to healthy volunteers to see if eye changes can help detect heart disease early.
Erlangen, BavariaAges 18–75 - NCT06613555Recruiting
Eye blood vessel scan study for systemic disease
This study uses an advanced eye scan (OCT-A) to look at tiny blood vessels in the back of the eye. It compares people with systemic blood vessel conditions (like high blood pressure or inflammatory disease) to healthy volunteers, to see if the eye scan can help predict or understand these diseases.
DijonAges 18 years+ - NCT04749927Recruiting
Image-based eye photos to study heart blood-vessel risks
This study uses deep learning (computer pattern recognition) to analyze retinal photos (pictures of the eye’s blood vessels). It aims to link what’s seen in the eye to heart and blood-vessel disease patterns, especially in people with higher cardiovascular risk.
SeoulAges 20–79 - NCT07228793Recruiting
A study tracking EYS-related retinitis pigmentosa over time
This study follows people with retinitis pigmentosa caused by changes in the EYS gene over 4 years. It collects data on how the disease progresses and does not test any new treatments.
MoscowAges 14–100 - NCT02317328Recruiting
Adaptive eye imaging to take very detailed retinal pictures
This study uses special “adaptive optics” equipment to capture very detailed images of the retina (the nerve layer at the back of the eye). It may help improve eye tests for people with eye disease and also includes some healthy volunteers.
Bethesda, MarylandAges 12–120 - NCT07244640Recruiting
Detecting Parkinson's through eye scans
This study uses a special eye camera to see if early signs of Parkinson's and similar movement disorders can be spotted in the retina. It may help doctors diagnose these conditions sooner and more easily.
Hangzhou, ZhejiangAges 40–80 - NCT03167203Enrolling by invitationPhase 1/Phase 2
Safety check after stem-cell eye treatment
This study follows people who previously received an embryonic stem-cell–derived treatment for macular (central) vision loss. Its goal is to watch for long-term side effects and better understand how safe the treatment is over time.
Kansas City, MissouriAges 18 years+ - NCT07396441RecruitingPhase 4
Kelulut honey therapy for juvenile glaucoma
This trial tests if adding Kelulut honey to standard treatment can help protect the optic nerve in young people with juvenile open-angle glaucoma. It looks at eye pressure, nerve thickness, and dry eye symptoms.
Kota Bharu, KelantanAges 15–40 - NCT06978998Recruiting
Retinal photos to help predict heart failure outcomes
This study tests whether a simple eye photo can help doctors better predict the course of heart failure with reduced pumping strength. If it works, this low-cost test could improve care for people with this condition.
SeoulAges 20 years+ - NCT07594236RecruitingPhase 1
Experimental Cell Therapy for Retinal Degeneration
This early-stage study tests a new cell-based treatment (C.001) for inherited retinal diseases that affect the back of the eye. The treatment may help slow vision loss or improve sight in people with geographic atrophy or Stargardt disease.
Beverly Hills, CaliforniaAges 18 years+ - NCT06375239Recruiting
Study of tests for tracking vision in retinal disease
This study will check if certain vision tests work well in people with retinal diseases like retinitis pigmentosa or Stargardt. Results will help design future trials.
Irvine, CaliforniaAges 18 years+ - NCT06416371Recruiting
Eye vessel leakage study for mild stroke survivors
This study uses eye scans to see if blood vessel leakage in the retina (back of the eye) is linked to small vessel disease in the brain after a mild stroke. It may help doctors better understand and monitor this condition.
EdinburghAges 18 years+ - NCT05644548Recruiting
Eye scan study for people with common health conditions
This study uses a special eye scan (OCTA) to look at how blood vessels in the retina change in people with conditions like high blood pressure, diabetes, or abnormal cholesterol. It may help doctors better understand how these common illnesses affect the eyes.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06565572Enrolling by invitationEarly Phase 1
Antisense drug for PCARP disease caused by FLVCR1 mutation
This trial tests a new drug called an antisense oligonucleotide (a type of genetic medicine) for people with a specific form of inherited eye disease called PCARP, which is caused by changes in the FLVCR1 gene. The goal is to see if the drug can slow or stop vision loss.
Aurora, ColoradoAges Any age - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age - NCT03761381Recruiting
Eye scan study for mild Alzheimer’s and memory changes
This study uses detailed eye imaging (an eye scan) to look for signs related to probable Alzheimer’s disease and mild dementia. It may help researchers understand whether eye scans can reflect brain changes and improve detection.
Portland, OregonAges 55 years+
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Common questions
- Are there clinical trials for retinal disease?
- Yes. Clin2 currently lists 77 recruiting retinal disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a retinal disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a retinal disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.