Clinical trials
Retinal Degeneration clinical trials
Below are recruiting retinal degeneration clinical trials, each written for real people, not researchers. We’re tracking 47 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05355415Recruiting
Eye imaging study for outer retina diseases using adaptive optics
This study uses a special, high-detail eye imaging machine to take clear pictures of the outer retina. It may help researchers understand these eye conditions better, and how the eye images look when people have an outer retinal disease.
Bethesda, MarylandAges 21 years+ - NCT06305416RecruitingPhase 3
Ranibizumab for diabetic macular edema
This trial tests an injection called Ranibizumab (10 mg/ml) to treat diabetic macular edema, a condition where fluid builds up in the center of the retina and causes blurry vision. The goal is to see if the drug is safe and effective at improving vision.
DhakaAges 18 years+ - NCT06319872RecruitingPhase 1
Study of disulfiram for vision in retinal degeneration
This trial tests whether disulfiram, a drug used for alcohol use disorder, can improve vision in people with retinal degeneration. You must have an alcohol use diagnosis and agree to avoid alcohol for 6 months.
Rochester, New YorkAges 18 years+ - NCT02617966Recruiting
Test of how rod and cone vision work in eye disease
This study measures how your eyes use two types of light-sensing cells (rods for dim light and cones for clearer detail). It may help researchers better understand retinal (retina) diseases and how well vision is functioning.
Bethesda, MarylandAges 5–100 - NCT01432847Recruiting
Collecting eye-related samples to study eye diseases
This study collects samples like blood and a small skin biopsy (and sometimes urine, hair, or saliva) to better understand causes of eye diseases. The goal is to study eye conditions and may help researchers build better tests or treatments.
Bethesda, MarylandAges 1 day–120 years - NCT07269665RecruitingEarly Phase 1
Gene therapy trial for children with BBS1 retinal degeneration
This early-phase trial tests a gene therapy called AXV-101 for children with vision loss caused by BBS1 genetic mutations. The goal is to see if it can help slow or stop retinal damage.
LondonAges 4–17 - NCT07266584Recruiting
Retinal implant for central vision loss in inherited eye disease
This trial tests a new implant (PRIMA) placed under the retina to help restore central vision in people with inherited retinal degeneration. If you have very poor central vision and a large enough area of retinal damage, this device may help you see better.
Sydney, New South WalesAges 18 years+ - NCT06375239Recruiting
Study of tests for tracking vision in retinal disease
This study will check if certain vision tests work well in people with retinal diseases like retinitis pigmentosa or Stargardt. Results will help design future trials.
Irvine, CaliforniaAges 18 years+ - NCT00254605Recruiting
Retinal photo imaging for inherited eye conditions
This study uses special pictures of the back of your eye (retinal imaging) in people with inherited retinal degeneration. It may help researchers learn how these conditions look and change over time, and it can be a way for you to receive detailed eye imaging.
San Francisco, CaliforniaAges 13 years+ - NCT05921162Enrolling by invitation
Long-term follow-up after a vision gene eye injection
This study checks how people who previously received a gene therapy eye injection (vMCO-I) are doing over the long term. It may help researchers understand long-lasting effects and safety.
Cuttack, OdishaAges 18 years+ - NCT05589714Recruiting
Study your rare eye gene and track retinal disease over time
This study builds a registry and tracks the natural history of rare retinal dystrophies while also testing people for disease-causing gene variants. It may help researchers better understand what causes retinal degeneration and how it progresses.
Little Rock, ArkansasAges 4 years+ - NCT07174687RecruitingPhase 2
SGLT2 inhibitor drug for geographic atrophy in dry AMD
This trial tests whether an SGLT2 inhibitor (a diabetes drug) can help slow geographic atrophy, a type of advanced dry age-related macular degeneration. It might be an option if you have dry AMD with specific types of retinal damage and haven't had other treatments.
St Louis, MissouriAges 50 years+ - NCT06394232RecruitingPhase 1/Phase 2
Testing a cell therapy for advanced dry AMD with geographic atrophy
This trial tests a new treatment called Eyecyte-RPE™, made from special cells that support the retina. It is given as a single injection under the retina during eye surgery. The study aims to see if it can help people with advanced dry age-related macular degeneration (AMD) who have large areas of damage (geographic atrophy) in the center of their vision.
Jālna, MaharashtraAges 50–100 - NCT05626920RecruitingPhase 1/Phase 2
Disulfiram trial for inherited vision loss in one eye
This early-stage study tests whether disulfiram can help preserve vision in people with inherited retinal degeneration. It focuses on one study eye and uses strict eye, blood/liver, and alcohol-avoidance rules because the medicine can affect the body and needs careful safety monitoring.
Seattle, WashingtonAges 18 years+ - NCT04129021Recruiting
Eye imaging test with fast detailed scans
This trial studies whether a new, very high-resolution and high-speed eye scan can be used for people with eye problems or for healthy volunteers. It may help doctors better “see” eye structures more clearly to guide care.
ParisAges 18 years+ - NCT07500324Recruiting
Searching for new markers in age-related eye diseases
This study looks for proteins in the blood and eye fluids that may help doctors better understand and monitor three common eye conditions: age-related macular degeneration, diabetic retinopathy, and retinal detachment. If you have one of these conditions, or if you are a healthy control with no retinal disease, you may be able to help by giving a small sample of blood or fluid from your eye during a routine procedure.
Roma, ItalyAges 18 years+ - NCT07056738Enrolling by invitation
Ganglion Cell Loss Study in Retinitis Pigmentosa
This study looks at whether a type of retinal cell (ganglion cells) degenerates in people with retinitis pigmentosa. The goal is to learn more about the progression of the disease over time.
GöttingenAges 18 years+ - NCT03011541Recruiting
Stem cell treatment for damaged retina or optic nerve
This study looks at stem-cell treatment to help vision in adults whose retina or optic nerve damage is not expected to improve on its own. You may be a candidate if your eye exam shows documented, stable or slowly changing damage and you can safely complete follow-up eye visits.
Westport, ConnecticutAges 18 years+ - NCT01866371Recruiting
High-detail eye scans for children and adults
This study tests a high-resolution imaging method that takes very detailed pictures of the retina (the light-sensing layer at the back of the eye). You might benefit by getting your eye health checked in a structured imaging study—if you’re able to comfortably complete the scan.
Philadelphia, PennsylvaniaAges 7 years+ - NCT07555574Recruiting
New imaging technology to see retinal structures clearly
This research study tests a new camera technology that takes detailed pictures of the back of your eye (retina) to better understand eye diseases. Researchers want to compare images from people with eye conditions like diabetes-related eye disease, glaucoma, or age-related macular degeneration with healthy volunteers to see how the new imaging works.
Melbourne, VictoriaAges 18 years+ - NCT06924021Recruiting
AMD Eye Image Library (ABID) Study
This study is creating a library of eye images to help doctors better diagnose age-related macular degeneration (AMD). You can join if you have healthy eyes or any stage of AMD that has never been treated.
Fargo, North DakotaAges 50 years+ - NCT06789445RecruitingPhase 1/Phase 2
Cell therapy for inherited retinal disease (CLARICO)
This study tests a new cell therapy (OpCT-001) for adults with inherited retinal diseases that affect the light-sensing cells. It aims to see if the treatment is safe and possibly helps improve vision.
Los Angeles, CaliforniaAges 18 years+ - NCT07594236RecruitingPhase 1
Experimental Cell Therapy for Retinal Degeneration
This early-stage study tests a new cell-based treatment (C.001) for inherited retinal diseases that affect the back of the eye. The treatment may help slow vision loss or improve sight in people with geographic atrophy or Stargardt disease.
Beverly Hills, CaliforniaAges 18 years+ - NCT06167642Enrolling by invitation
Retinal health and nerve markers in MS patients taking ofatumumab
This study looks at how ofatumumab (Kesimpta) affects the back of the eye (retina) and certain nerve proteins in the blood in people with relapsing multiple sclerosis. It may help doctors understand how well the medication is protecting the eyes and nerves.
Baltimore, MarylandAges 18–70
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Retinal Degeneration trials by city
Studies with a site in or near these metro areas.
Retinal Degeneration trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for retinal degeneration?
- Yes. Clin2 currently lists 47 recruiting retinal degeneration studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a retinal degeneration trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a retinal degeneration trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.