Clinical trials
Rhinosinusitis clinical trials
Below are recruiting rhinosinusitis clinical trials, each written for real people, not researchers. We’re tracking 67 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06914908Enrolling by invitationPhase 2
Long-term safety study of lunsekimig for nasal polyps
This study tests the long-term safety and effectiveness of a medication called lunsekimig for people with chronic sinusitis and nasal polyps. It is for those who already completed a previous study on this drug.
La Jolla, CaliforniaAges 18 years+ - NCT06850805RecruitingPhase 3
Nasal spray for teens with chronic sinusitis without polyps
This study tests a new nasal spray (OPN-375) for teens aged 12–17 with chronic sinusitis but without nasal polyps. It aims to see if the spray improves symptoms like congestion and runny nose.
Huntsville, AlabamaAges 12–17 - NCT06501807Recruiting
Biologics for severe nasal polyps: a French registry study
This study follows patients in France who are receiving biologic treatments for severe nasal polyps with chronic sinusitis. It collects information on how well these treatments work and their side effects over time.
LilleAges 18 years+ - NCT06338995RecruitingPhase 3
Lebrikizumab for nasal polyps and sinusitis
This trial tests a new injectable medicine (lebrikizumab) for people with chronic sinusitis and nasal polyps that steroid treatments haven't controlled. It aims to reduce polyp size and improve breathing, smell, and congestion.
Birmingham, AlabamaAges 12 years+ - NCT06118554Recruiting
Testing a 3D-printed tool for better sinus rinses
This study tests whether a 3D-printed tool can help people with chronic sinusitis get better results from nasal rinses. It might help if your sinus rinses don't reach deep enough into your nasal passages.
Columbus, OhioAges 18–75 - NCT03439865RecruitingEarly Phase 1
Ivacaftor for sinus problems linked to faulty CFTR
This early-phase study tests whether ivacaftor can improve chronic sinus disease caused by problems with a specific body channel called CFTR. It may help some people whose sinus imaging, cultures, and prior sinus surgery match the study’s criteria.
Birmingham, AlabamaAges 18 years+ - NCT02038166Recruiting
Measuring nasal function in adults with chronic sinus symptoms
This study tests a specialized way of measuring how your nasal lining responds in people with chronic rhinosinusitis (long-lasting sinus inflammation). The goal is to see whether the nasal measurement is usable and safe, and to help better understand chronic sinus disease.
Birmingham, AlabamaAges 18 years+ - NCT07867184Enrolling by invitation
Firefighter lung health study
This study looks at how firefighting affects your lungs over time. By tracking your health and exposures, researchers hope to find ways to prevent lung problems in firefighters.
Bethesda, MarylandAges 18–65 - NCT04645511Recruiting
Balloon treatment for long-term or repeat maxillary sinusitis
This study tests whether balloon sinuplasty works better or more efficiently for people with long-lasting or repeatedly returning inflammation in the maxillary sinuses (side sinuses near your cheeks). It focuses on people who did not improve with the usual nose spray (topical steroid) or who meet specific “recurrent” episode patterns.
TampereAges 18–69 - NCT05061329Recruiting
Learn how the nose’s microbes relate to health and disease
This study explores the tiny living organisms (microbes) in your nose and how they may be linked to health problems. It may help researchers better understand disease triggers and potential new prevention or treatment ideas.
Holstebro, Central JutlandAges 18 years+ - NCT05708300Recruiting
Testing how mepolizumab works for people with nasal polyps
This study looks at blood and other measures (biomarkers) to understand how well mepolizumab helps people with nasal polyps, with or without asthma. It aims to find response clues that could help personalize treatment in the future.
Thessaloniki, ExochiAges 18 years+ - NCT05938972Recruiting
Study of biologic medicines in severe CRSwNP patients
This study looks at how “biologic” medicines work in real-life care for people with severe chronic rhinosinusitis with nasal polyps (CRSwNP). It may help confirm which patients benefit and how treatment is used in everyday practice.
GhentAges 18–80 - NCT07782970RecruitingPhase 3
Treatment for chronic sinusitis with nasal polyps
This study tests a new medication (felcorekibart) to see if it reduces nasal polyps and symptoms like congestion and loss of smell. It may help people whose current treatments aren't enough.
Los Angeles, CaliforniaAges 18 years+ - NCT07782957RecruitingPhase 3
New shot for severe nasal polyps with ongoing sinus symptoms
This study tests an experimental medication called felcorekibart, given as an injection, to see if it reduces nasal polyps and improves sinus symptoms like congestion and loss of smell. It is for adults who have had nasal polyps for at least a year and have already tried standard treatments like steroid sprays or pills, or had surgery.
Sherman Oaks, CaliforniaAges 18 years+ - NCT07714525RecruitingPhase 2
Steroid nanocapsules after nasal surgery
This trial tests whether a new form of steroid (triamcinolone) delivered in tiny capsules can improve healing after common nasal surgeries for chronic sinusitis or nasal polyps.
Minya, Menia GovernorateAges 18–60 - NCT07701967RecruitingPhase 4
Depemokimab for chronic sinusitis with nasal polyps
This trial tests a new antibody medicine (depemokimab) for Japanese adults with chronic sinusitis and nasal polyps. It aims to see if the drug alone can reduce symptoms without needing steroid nasal sprays.
EhimeAges 18 years+ - NCT07681973Recruiting
Smell training for loss of smell in sinus patients
This study tests whether smell training can improve your sense of smell and affect your immune system. It is for people with chronic sinus inflammation and nasal polyps who have lost their sense of smell.
Cleveland, OhioAges 18 years+ - NCT07633158Recruiting
Real-world study of tezepelumab for chronic nasal polyps
This study follows patients with chronic rhinosinusitis with nasal polyps (CRSwNP)—a condition causing blocked sinuses and nasal growths—who are starting a new biologic medication called tezepelumab. Researchers will track how symptoms and quality of life improve over time in everyday medical practice.
BochumAges 18–130 - NCT07546682Recruiting
Propel Sinus Implant Study in Japan
This study tests a steroid-releasing implant placed during sinus surgery to help prevent inflammation and improve healing in patients with chronic sinus infections. If you're having sinus surgery in Japan, this trial may track how well the implant works for you.
AsahikawaAges 18 years+ - NCT07520162RecruitingPhase 3
Tezepelumab for Nasal Polyps in Chinese Adults
This study tests whether tezepelumab, a new injectable medicine, can help reduce nasal polyps and improve symptoms like nasal congestion, loss of smell, and sleep problems. You would receive the study drug while continuing your current nasal steroid spray, and your doctors would track how your symptoms change.
BeijingAges 18 years+ - NCT07299474Recruiting
Lavender scent for anxiety and pain during awake ENT procedures
This study tests whether smelling lavender essential oil during an awake ear, nose, or throat procedure can help reduce anxiety and pain. If you qualify, you may receive the lavender scent during your procedure and report how you feel.
Los Angeles, CaliforniaAges 18 years+ - NCT07262450Recruiting
Seawater spray for stuffy nose and sinus symptoms
This trial tests whether a seawater nasal spray can relieve nasal congestion, runny nose, and other sinus symptoms in people with colds, allergies, or after nose surgery. You will use the spray as directed and answer online questionnaires for up to 3 months.
BordeauxAges 2 weeks+ - NCT07259538RecruitingPhase 1
Safety study of VVN432 nasal spray
This trial tests a nasal spray called VVN432 in healthy volunteers and people with chronic sinusitis. It checks if the spray is safe and how the body processes it.
BeijingAges 18–55 - NCT07174115RecruitingPhase 2
Testing a new tablet for chronic sinusitis without nasal polyps
This trial tests an experimental tablet (HTMC0658) for people with chronic sinusitis that hasn't improved with standard nasal spray. You may join if your symptoms are moderate to severe and you've been using a stable dose of mometasone spray for at least 4 weeks.
Luoyang, HenanAges 18–75
Hear when a new Rhinosinusitis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for rhinosinusitis?
- Yes. Clin2 currently lists 67 recruiting rhinosinusitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a rhinosinusitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a rhinosinusitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Chronic Rhinosinusitis With Nasal Polyps
- Chronic Rhinosinusitis (CRS)
- Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
- Chronic Rhinosinusitis (Diagnosis)
- Chronic Rhinosinusitis
- Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
- Chronic Rhinosinusitis Without Nasal Polyps
- Non Small Cell Lung Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.