Clinical trials
Schizophrenia and Other Psychotic Disorders clinical trials
Below are recruiting schizophrenia and other psychotic disorders clinical trials, each written for real people, not researchers. We’re tracking 89 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06229210RecruitingPhase 3
Lumateperone safety study for children with schizophrenia, bipolar, or autism
This trial tests a medication called lumateperone for children and teens with schizophrenia, bipolar disorder, or autism spectrum disorder. It aims to see if the medicine is safe and tolerable over time.
Phoenix, ArizonaAges 5–17 - NCT06138054Recruiting
Mobile Program for Veterans with Mental Illness and Homelessness History
This trial tests a smartphone-based program to help veterans with serious mental illness who have experienced homelessness feel more connected to their community. It aims to see if the mobile coaching can improve daily living skills and reduce feelings of isolation.
West Los Angeles, CaliforniaAges 18–65 - NCT05973110Recruiting
Virtual reality training to improve thinking in psychosis
This trial tests whether a virtual reality program can help people living with psychosis improve thinking and daily functioning. It may help if your symptoms are currently stable and you can safely use the VR equipment.
Ottawa, OntarioAges 18–60 - NCT04323566Enrolling by invitationPhase 2
Rituximab for OCD or psychosis linked to immune inflammation
This trial tests rituximab (an immune system medicine) to see if it can reduce OCD symptoms and/or psychosis when there are signs the immune system may be involved. You may be considered if other standard psychiatric treatments have not helped enough and your illness seems relatively recent with possible inflammation clues.
UppsalaAges 18–55 - NCT03525054Recruiting
Brain-and-speech study after suicidal thoughts or actions
This study looks at how people use language (free speech) after a suicidal gesture, idea, or related behavior that affected their life. The researchers use computer-based analysis to understand patterns in speech and thinking, which may help improve support and assessment.
BrestAges 15–30 - NCT06872463Recruiting
Karolinska Schizophrenia Project: Brain study for first episode psychosis
This study examines the brain in people having their first episode of psychosis (like hearing voices or strong false beliefs) to understand more about schizophrenia and related conditions. It involves MRI scans and other tests over one year.
StockholmAges 18 years+ - NCT06624462Recruiting
Meta Care Clinic for weight and health in severe mental illness
This study tests a special clinic that helps people with schizophrenia or bipolar disorder manage their weight and metabolic health while taking antipsychotic medication. It focuses on improving overall health with practical support.
Glostrup Municipality, Capital RegionAges 18–45 - NCT06743711Recruiting
Heart fitness in severe mental illness study
This study checks how fit your heart and lungs are if you have a serious mental illness like schizophrenia or bipolar disorder. It aims to see if fitness can help improve health and well-being.
Glostrup MunicipalityAges 18–45 - NCT05656469Recruiting
Personalized psychiatry meds using gene test results
This study compares a personalized medication plan based on your genes versus standard dosing for people with depression, anxiety, or psychosis. It may help your clinician choose a safer or more effective dose or medicine by using pharmacogenomics (gene-informed prescribing).
Syracuse, New YorkAges 16–70 - NCT05951660Recruiting
Study sexual side effects in schizophrenia with diabetes
This study looks at how sexual functioning is affected in people with schizophrenia, especially in those who also have diabetes or weight-related risk. It also examines how psychiatric medicines and diabetes/weight factors may be connected, which could help improve care for patients.
SlagelseAges 18 years+ - NCT07671261Recruiting
Brain surgery for schizophrenia guided by electrode mapping
This trial tests whether deep brain stimulation (DBS) guided by SEEG (a way to map brain activity with electrodes) can help treat schizophrenia. It is for people with moderate to severe symptoms who have not improved after trying at least two different antipsychotic medications.
Shanghai, Shanghai MunicipalityAges 18–55 - NCT04432116Recruiting
Virtual reality training for schizophrenia and bipolar symptoms
This study looks at whether virtual reality and time-based training can improve symptoms for people with schizophrenia or bipolar disorder. You may do virtual-reality tasks as part of your care plan while the team tracks changes over time.
StrasbourgAges 18–60 - NCT03649581Recruiting
Brain-scan study in catatonia and hebephrenia with stable schizophrenia
This study measures brain signals during scans to look for patterns linked to two types (subforms) of psychotic disorders. If you have schizophrenia or schizoaffective disorder and your symptoms have been stable, you may be able to help researchers understand these brain markers.
StrasbourgAges 18–65 - NCT04370730Recruiting
Study brain and symptoms in youth with early psychosis
This study looks at how psychosis symptoms and development change over time in children and teens. It may help doctors better understand different patterns of illness and how to support young people with these disorders.
GentillyAges 7–20 - NCT07743645Recruiting
Preventing schizophrenia in teens with family history
This study tests whether a program can help prevent schizophrenia and related conditions in young people who have a family history of these illnesses. It focuses on identifying early risk factors and providing support to reduce the chance of developing the disorder.
Houston, TexasAges 9–19 - NCT07692984Recruiting
Alcohol and drug use in people with schizophrenia or bipolar disorder
This study looks at how alcohol and substance use affects people with schizophrenia or bipolar disorder. It aims to understand if having these conditions together changes treatment or outcomes.
Bolu, BoluAges 18–65 - NCT00762866Enrolling by invitation
Study of mental health traits using genetic and brain measurements
This study collects information about mental health symptoms and body/genetic samples to better understand how different mental health conditions are related. Some people may also have brain scans (PET or MRI) if they can safely complete them.
Nashville, TennesseeAges 16–65 - NCT04113993RecruitingPhase 4
Bazedoxifene study in women with schizophrenia
This trial tests whether bazedoxifene can help women with schizophrenia who are stable on their current medicines. You may be asked to do questionnaires and thinking (cognitive) tests to see if symptoms or brain-related measures change.
Melbourne, VictoriaAges 18–65 - NCT05890183Recruiting
Telehealth exercise and brain training after a first psychosis episode
This trial tests whether a combination of at-home (telehealth) aerobic exercise and computer-based cognitive training can improve thinking and day-to-day function after a first episode of schizophrenia-spectrum illness. It may help by strengthening attention and learning skills after the initial psychotic episode.
Los Angeles, CaliforniaAges 18–45 - NCT05445180Recruiting
Brain scan study of thinking in cannabis users with psychosis
This study uses brain imaging to understand how thinking works in people who use cannabis, comparing those with psychosis to people without psychosis. It may help researchers learn what brain patterns relate to thinking difficulties and how cannabis use fits in.
Montreal, QuebecAges 16–80 - NCT07569471Recruiting
Group compassion therapy for psychosis beliefs
This study tests a new group-based therapy that combines compassion-focused techniques with cognitive behavioral therapy to help people with schizophrenia or related conditions change their beliefs about their psychosis. The goal is to reduce distress and improve how you cope with symptoms.
Scarborough Village, OntarioAges 18 years+ - NCT06568081Recruiting
Studying a therapy for paranoia in psychosis
This trial tests a therapy for people with psychosis who also experience paranoia. It aims to see if the therapy works and whether it's cost-effective in routine care.
LondonAges 18 years+ - NCT05603104RecruitingPhase 3
Medication intensification after first treatment failure in mood and psychosis
This Phase 3 study tests a stronger medication approach after your first current treatment hasn’t worked well enough. It targets people with schizophrenia, major depressive disorder, or bipolar depression who still have significant symptoms and life impact.
Ramat GanAges 18–70 - NCT06778564RecruitingPhase 3
CBD (cannabidiol) for early psychosis
This study tests if adding a CBD medication to your current antipsychotic can improve symptoms in people with schizophrenia or related disorders who started treatment recently but aren't fully better yet.
ViennaAges 16–40
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Common questions
- Are there clinical trials for schizophrenia and other psychotic disorders?
- Yes. Clin2 currently lists 89 recruiting schizophrenia and other psychotic disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a schizophrenia and other psychotic disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a schizophrenia and other psychotic disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.