Clinical trials
Severe Mental Illness clinical trials
Below are recruiting severe mental illness clinical trials, each written for real people, not researchers. We’re tracking 44 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06376734RecruitingPhase 2
TMS for depression, anxiety, OCD, or schizophrenia
This study tests whether a brain stimulation technique called TMS can help people with depression, anxiety, OCD, or schizophrenia. It aims to find better ways to target the treatment for each person's specific needs.
Sunnyvale, CaliforniaAges 18–65 - NCT07730307Recruiting
Study on sharing suicidal thoughts and getting support
This study looks at how people share their experiences with suicidal thoughts or severe depression and what happens when they seek support. It aims to help understand the risks and benefits of talking about these struggles.
Mpunde, Buyende DistrictAges 18 years+ - NCT07658066Recruiting
Football to reduce stigma toward mental illness in students
This study tests whether playing football (soccer) can help reduce stigma toward mental illness. It compares the effectiveness of actual interaction with people who have mental illness versus watching videos. If you are a healthy university student who can safely play football, you may be eligible.
Kaohsiung CityAges 18–30 - NCT07571226Recruiting
Urban Stress and Mental Health Monitoring Study
This study explores how city living and daily stress affect depression, anxiety, and alcohol use disorders by having you wear a monitoring wristband and use a smartphone app to track your physical responses. Researchers hope to better understand the link between environmental stress and mental health symptoms.
BeijingAges 18–60 - NCT07499440RecruitingPhase 2
Testing a new medicine, HB-1, for PTSD
This trial tests an experimental medicine, HB-1, as a potential treatment for PTSD. It is a 8-week study to see if the medicine is safe and if it reduces PTSD symptoms. You must have a stable medication routine and be willing to take the study pill daily.
Deakin, Australian Capital TerritoryAges 18–65 - NCT07106385Recruiting
rTMS for better sleep in healthy adults
This study tests if a non-invasive brain stimulation method called rTMS can help improve sleep in adults who are generally healthy but have sleep complaints. If you are 18–65 and often have trouble sleeping, this might be a way to try a new approach without medication.
Hong Kong, Pok Fu LamAges 18–65 - NCT07106398Recruiting
Can brain stimulation reduce food cravings and help weight control?
This study tests whether a non-invasive brain stimulation technique called rTMS can help reduce food cravings and support weight control in adults who struggle with these issues but are otherwise healthy.
Hong Kong, Pok Fu LamAges 18–65 - NCT06951542Enrolling by invitation
Reducing HIV and mental health stigma in Malawi
This study tests a program to reduce stigma for people living with HIV who also have symptoms of depression. It aims to improve mental health and HIV outcomes.
MulanjeAges 18 years+ - NCT06543407Recruiting
Safer smoking options for people with mental illness
This study offers a way to reduce harm from smoking for people with mental health conditions who are not ready to quit. It tests if switching to a less harmful product can help improve health without requiring you to stop smoking completely.
Louisville, KentuckyAges 21 years+ - NCT05776316Recruiting
Harm-reduction support for adults using opioids
This trial offers harm-reduction services for adults who have been misusing opioids (and sometimes other substances) recently. It’s designed to test support approaches that may reduce risks and improve well-being.
New Haven, ConnecticutAges 18 years+ - NCT05538910Recruiting
Brain imaging study on substance use and depression
This study uses brain scans to understand how substance use and mental illness, like depression, are linked. It may help develop better treatments by looking at brain activity in people with and without depression.
Baltimore, MarylandAges 18–60 - NCT05537376Recruiting
Peer-led suicide prevention support for veterans with serious mental illness
This study tests a suicide-prevention program delivered by trained peer specialists (other people with similar lived experience) to help veterans who are currently having suicidal thoughts. It aims to add ongoing support and improve safety and recovery for veterans with serious mental health conditions.
San Diego, CaliforniaAges 18 years+ - NCT05491538Recruiting
Work-focused social skills training for veterans with mental illness
This study tests a program to help veterans with serious mental illness improve social skills for work and find jobs near the VA. It aims to see if the program is acceptable and feasible for participants.
Minneapolis, MinnesotaAges 18 years+ - NCT04588311RecruitingPhase 3
Epoetin to improve outcomes in severe trauma ICU patients
This trial tests epoetin alfa (a blood-building medicine) to help reduce death and severe disability in critically ill trauma patients in the ICU. You may be considered if your ICU team expects a longer stay and the timing after injury is early.
Camperdown, New South WalesAges 18–75 - NCT02531893Recruiting
Therapy for youth with severe, frequent irritability
This study tests whether two structured therapies can reduce severe irritability and angry reactions in children and teens. It focuses on youth who have had long-lasting, frequent outbursts and trouble responding to negative emotions.
Bethesda, MarylandAges 8–17 - NCT07483333Recruiting
Comparing two group therapies for kids with medical conditions and trauma
This study compares two types of group therapy for youth ages 8–18 who have a chronic medical condition and trauma-related distress. The goal is to see which type of group helps kids feel better and handle their health challenges.
Chicago, IllinoisAges 8–18 - NCT00025935Recruiting
Brain function study in children with mood problems
This study looks at how the brain works and how mood disorders change over time in children and teens with severe irritability, anger, and temper outbursts. It includes brain scans and regular check-ins to understand the illness better.
Bethesda, MarylandAges 7–85 - NCT05765864Recruiting
Study of self-harm in at-risk teens
This study looks at self-harm and thoughts/behaviors related to safety in teenagers who are considered at higher risk. It may help researchers better understand what supports are needed for teens who self-harm without wanting to die.
LjubljanaAges 13–18 - NCT06005103Recruiting
Testing a headband that sends brain pulses for depression
This study tests a new headband that sends gentle electrical pulses to the brain (T-PEMF) to lift depression. You might join if you have moderate to severe depression and don't have certain other conditions or implants.
Frederiksberg, Capital RegionAges 18–65 - NCT05461092RecruitingEarly Phase 1
Nerve blocks to improve pain control after spinal fusion
This early-stage study tests whether a regional nerve block can improve pain control and recovery for older adults having elective lumbar spinal fusion. If you qualify, you may receive a special pain-control injection during surgery to reduce opioid needs and improve recovery comfort.
Iowa City, IowaAges 65 years+
Hear when a new Severe Mental Illness trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for severe mental illness?
- Yes. Clin2 currently lists 44 recruiting severe mental illness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe mental illness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe mental illness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.